Results 91 to 100 of about 8,575 (176)

Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells

open access: yesJournal of Pharmacological Sciences, 2004
In guinea pig single ileal smooth muscle cells held under voltage-clamp, the role of phospholipase C (PLC) in activation of the muscarinic receptor-operated cationic current (Icat) was studied. U73122, a PLC inhibitor, prevented the generation of Icat by
Hiroyuki Okamoto   +7 more
doaj   +1 more source

Myocardin promotes calcium influx in response to carbachol.

open access: yes, 2012
Embryoid bodies were treated with Ad-LacZ or Ad-Myo from day 10 to day 28 and then dispersed into a single cell suspension. Cells were loaded with Fluo-4, a calcium sensitive fluorophore, and intracellular [Ca2+] was measured by flow cytometry before and
Christine Cheung (140432)   +3 more
core   +1 more source

Die Carbachol-induzierte Chloridsekretion am proximalen Kolon des Pferdes [PDF]

open access: yes, 2005
Akute Durchfallerkrankungen kommen weltweit bei Pferden vor. Ihre besondere Bedeutung liegt zum einen in ihrem häufig letalen Ausgang, zum anderen kann ihre Therapie sehr zeit- und kostenaufwendig sein.
Lamberti, Nicole
core   +1 more source

Unique responses of the fixed stoichiometric TRPC1–TRPC5 concatemer to G proteins

open access: yesFrontiers in Physiology
Transient receptor potential canonical (TRPC)5 channel is a non-selective cation channel that plays a significant role in membrane depolarization and calcium influx. TRPC5 not only forms homotetramers itself but also heterotetramers with TRPC1.
Hana Kang, Insuk So, Insuk So
doaj   +1 more source

Doxazosin Effects on Cholinergic and Adrenergic Responses in Rat Isolated Detrusor Smooth Muscle Preparations From Obstructed Bladder

open access: yesJournal of Pharmacological Sciences, 2004
We investigated the effect of doxazosin on cholinergic and adrenergic agonists responses in detrusor smooth muscle preparations from sham-operated and 2-week partially obstructed rat bladders. Male Wistar albino rats, 200 – 250 g, were randomly allocated
Coşkun Usta   +2 more
doaj   +1 more source

Carbachol-induced down-regulation of high-affinity receptors for vasoactive intestinal peptide

open access: yes, 1989
When dispersed acini from guinea pig pancreas are first incubated with carbachol, the subsequent binding of 125I-vasoactive intestinal peptide (VIP) is inhibited during a second incubation.
R. T. Jensen   +3 more
core   +1 more source

Corticosteroid-mediated modulation of carbachol responsiveness in CA1 pyramidal neurons. A voltage clamp analysis

open access: yes, 1995
Pyramidal neurons in the rat hippocampal CA1 area contain mineralocorticoid (MRs) and glucocorticoid (GRs) receptors for corticosterone. Previous current clamp experiments showed that depolarizations evoked by carbachol(1–3 μM) depend on relative MR/GR ...
Hesen, W., Joëls, M.
core   +1 more source

Comparisons of urinary bladder responses to common antimuscarinics reveals unique effects of darifenacin

open access: yesFrontiers in Physiology
IntroductionAntimuscarinics are the first-line pharmaceutical treatment for overactive bladder (OAB). However, some literature suggests that responses to these antimuscarinics can influence a variety of non-muscarinic receptors.
Vineesha Veer   +2 more
doaj   +1 more source

Biphasic effects of carbachol on stimulated cAMP accumulation in mouse parotid acini

open access: yes, 1993
Carbachol (0.1-10 microM) augmented the isoproterenol-stimulated adenosine 3',5'-cyclic monophosphate (cAMP) accumulation by approximately 50% in mouse parotid acini; at carbachol concentrations > 10 microM the stimulatory trend was reduced.
E. L. Watson   +3 more
core   +1 more source

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