Results 11 to 20 of about 14,304 (180)
In vitro study of spontaneous motility and cholinergic responses in the human Hirschsprung's disease colon [PDF]
Frontiers in PediatricsBackgroundThe current standard treatment of Hirschsprung's disease (HD) involves complete resection of the aganglionic intestinal segment with routine rectal irrigation pre- and postoperatively.
Felix Schulze +7 more
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The Antipsychotic Aripiprazole Induces Cytotoxicity in Bladder Cancer Cells While Preserving Urothelial and Bladder Function. [PDF]
Pharmacol Res PerspectCurrent bladder cancer therapies can cause toxicity and bladder dysfunction. Brief intravesical‐like aripiprazole exposure reduced bladder cancer cell viability and was associated with redox stress and caspase‐3 activation, while ex vivo findings suggested preserved bladder structure and function, warranting further investigation as a potential ...
O'Callaghan LA +3 more
europepmc +2 more sources
MiR-21-5p Protects Embryonic Growth and Heart Function During Developmental Hypoxia by Dampening HIF Responses and Altering Gene Expression. [PDF]
Compr PhysiolmiR‐21‐5p protects embryonic growth and heart function during developmental hypoxia by dampening HIF responses and shifting gene networks toward improved cardiomyocyte survival and calcium handling. This work identifies miR‐21‐5p as a promising therapeutic target for preventing fetal growth restriction and cardiovascular impairment in high‐risk ...
Krause BJ +12 more
europepmc +2 more sources
Mechanisms of carbachol oscillations
BMC Neuroscience, 2007 Netoff Theoden I +2 more
doaj +3 more sources
Water Drinking Behavior Associated with Aversive Arousal in Rats: An Integrative Approach
Brain Sciences, 2022 Cholinergic muscarinic stimulation of vast areas of the limbic brain induced a well-documented polydipsia in laboratory rats. This excessive water-drinking behavior has not received any convincing biological and physiological interpretation for the last ...
Stefan M. Brudzynski
doaj +1 more source
KV7 Channel Expression and Function Within Rat Mesenteric Endothelial Cells
Frontiers in Physiology, 2020 Background and Purpose: Arterial diameter is dictated by the contractile state of the vascular smooth muscle cells (VSMCs), which is modulated by direct and indirect inputs from endothelial cells (ECs).
Samuel N. Baldwin +4 more
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Frontiers in Synaptic Neuroscience, 2022 Recent studies have implicated impaired Parvalbumin Fast-Spiking Interneuron (PVIN) function as a precipitating factor underlying abnormalities in network synchrony, oscillatory rhythms, and cognition associated with Alzheimer’s disease (AD).
Connie A. Mackenzie-Gray Scott +9 more
doaj +1 more source
Molecules, 2021 Dysphania ambrosioides (L.) Mosyakin and Clemants is an annual or ephemeral perennial herb used traditionally in the Mediterranean region in folk medicine to treat various illnesses, including those related to the digestive system.
Fahd Kandsi +9 more
doaj +1 more source
Muscarinic Receptors as Targets for Metronomic Therapy in Ovarian Cancer
Düzce Tıp Fakültesi Dergisi, 2023 Aim: In this study, the effects of muscarinic acetylcholine receptor (mAChR) agonist carbachol on the proliferation of cisplatin-resistant (A2780cis) and cisplatin-free (SKOV-3) ovarian cancer cell line were for the first time investigated to further ...
Fatma Söylemez +1 more
doaj +1 more source
Carbachol and Nicotine in Prefrontal Cortex Have Differential Effects on Sleep-Wake States
Frontiers in Neuroscience, 2020 The role of the brainstem cholinergic system in the regulation of sleep-wake states has been studied extensively but relatively little is known about the role of cholinergic mechanisms in prefrontal cortex in the regulation of sleep-wake states.
Anjum Parkar +11 more
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