Results 11 to 20 of about 28,706 (230)

Sex-Dependent Effects of Angiotensin II and Calcineurin in the Vasculature of Mice. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Cardiovascular diseases display strong sex differences. Angiotensin II (AngII) is implicated in this process. The ubiquitously expressed enzymatic beta subunit of calcineurin (PPP3CB), a serine/threonine phosphatase, can mediate pathological effects of AngII in the heart.
Nolze A, Rabe S, Ruhs S, Strätz N, Quarch K, Köhler C, Grossmann C.   +6 more
europepmc   +2 more sources

Intracellular stored calcium plays a minor role in Gq-coupled receptor-mediated contraction in rat airway smooth muscle

Life Sciences, Medicine and Biomedicine, 2018
The general notion of activation of Gq-protein coupled receptors involves the mobilisation of stored and extracellular calcium and leads to smooth muscle tissue contraction.
Kayatri Govindaraju, Mei Kee Lee, Yvonne Mbaki, Ting Kang Nee   +3 more
doaj   +1 more source

The Muscarinic Acetylcholine M₂ Receptor-Induced Nitration of p190A by eNOS Increases RhoA Activity in Cardiac Myocytes

Cells, 2023
p190RhoGAP, which exists in two paralogs, p190RhoGAP-A (p190A) and p190RhoGAP-B (p190B), is a GTPase activating protein (GAP) contributing to the regulation of the cellular activity of RhoGTPases.
Magdolna K. Levay, Lena Throm, Nabil Bahrami, Thomas Wieland   +3 more
doaj   +1 more source

Carbachol increases intracellular free calcium concentrations in human granulosa-lutein cells [PDF]

, 1992
We investigated whether the stimulation of human granulosa-lutein cells with muscarinic and nicotinic receptor agonists can cause increases in intracellular free calcium (Ca2+), using Fura-2 microfluorimetry.
Föhr, K. J., Gratzl, Manfred, Mayerhofer, Artur, Sterzik, K.   +3 more
core   +1 more source

Medial Septum Modulates Cellular Response Induced in Hippocampus on Microinjection of Cholinergic Agonists into Hypothalamic Lateral Supramammillary Nucleus

Frontiers in Neuroanatomy, 2017
Cholinergic mechanisms in supramammillary nucleus (SuM), especially the lateral SuM (lSuM) modulates septo-hippocampal neural activity. The lSuM, as compared to the contiguous medial SuM (mSuM) has relatively dense projections to hippocampus and ...
Mohammed Z. Ariffin, Chian-Ming Low, Chian-Ming Low, Sanjay Khanna, Sanjay Khanna   +4 more
doaj   +1 more source

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source

Development and Application of a Functional Human Esophageal Mucosa Explant Platform to Eosinophilic Esophagitis. [PDF]

, 2019
There is an increasing prevalence of esophageal diseases but intact human tissue platforms to study esophageal function, disease mechanisms, and the interactions between cell types in situ are lacking.
Aceves, Seema S, Adejumobi, Dolapo, Akuthota, Praveen, Dohil, Ranjan, Duong, Loan D, Jones, Stacie M, Kurten, Richard C, Levy, Rebecca, Newbury, Robert O, Rawson, Renee, Rothenberg, Marc E, Shoda, Tetsuo, Wright, Benjamin L   +12 more
core   +3 more sources

Rapid recycling of Ca2+ between IP3-sensitive stores and lysosomes. [PDF]

PLoS ONE, 2014
Inositol 1,4,5-trisphosphate (IP3) evokes release of Ca2+ from the endoplasmic reticulum (ER), but the resulting Ca2+ signals are shaped by interactions with additional intracellular organelles.
Cristina I López Sanjurjo, Stephen C Tovey, Colin W Taylor   +2 more
doaj   +1 more source

Cholinergic modulation of epileptiform activity in the developing rat neocortex [PDF]

, 1989
The effects of carbachol on picrotoxin-induced epileptiform activity and membrane properties of neurons in the developing rat neocortex were examined in an in vitro slice preparation.
Ben-Ari, Benardo, Bernd Sutor, Donoghue, Ferguson, Gutnick, Gähwiler, Haas, Haas, Hablitz, Hablitz, Hablitz, Halliwell, Hounsgaard, John J. Hablitz, Johnston, Kriegstein, Kriegstein, Krnjevic, Krnjevic, Lamour, Lamour, Madison, McCormick, McCormick, McLennan, Metherate, North, Pennefather, Sikes, Stone, Strejckova, Traub, Valentino, Vogt, Yamamoto   +35 more
core   +1 more source

Reduction in jejunal fluid absorption in vivo through distension and cholinergic stimulation not attributable to enterocyte secretion [PDF]

, 2018
Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected.
Graham, V., Kenward, H., Lucas, M., McColl, S., McNaughton, E., Sabir, S., Tainsh, P., Turkington, C., Watson, P.   +8 more
core   +1 more source