Results 191 to 200 of about 11,132 (239)

A humanized Gs-coupled DREADD for circuit and behavior modulation. [PDF]

Front Cell Neurosci
Zhang Q, Wang R, Zhang L, Li M, Lin J, Lu X, Tian Y, Lin Y, Liu T, Chen Y, Li Y, Cao J, Wu Q, Wang J, Lu Z, Hong Z.   +15 more
europepmc   +1 more source

Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity. [PDF]

ChemistryOpen
Ghosh Situ S, Bhuia MS, Chowdhury R, Al Hasan S, Akber Ansari S, Aamer Ansari I, Ali A, Torequl Islam M.   +7 more
europepmc   +1 more source

Exploring the mechanism of action of Lobetyolin in the treatment of allergic rhinitis based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Hou L, Yang J, Li Y, Kang J, Ma Z, Luo X, Yang X, Shao H.   +7 more
europepmc   +1 more source

The Cardiomyocyte in Cirrhosis: Pathogenic Mechanisms Underlying Cirrhotic Cardiomyopathy. [PDF]

Rev Cardiovasc Med
Ryu DG, Yu F, Yoon KT, Liu H, Lee SS.
europepmc   +1 more source

Recent Advances in Ionic Mechanisms in Pituitary Cells: Implications for Electrophysiological and Electropharmacological Research. [PDF]

J Clin Med
Wu SN, Wang YJ, Gao ZH, Liutkevičienė R, Rovite V.   +4 more
europepmc   +1 more source

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A model of the human M2 muscarinic acetylcholine receptor.

Journal of computer-aided molecular design, 2002
The M2 muscarinic acetylcholine receptor belongs to the family of rhodopsin like G-Protein Coupled Receptors. This subtype of muscarinic receptors is of special interest because it bears, aside from an orthosteric binding site, also an allosteric binding site.
Hans-Dieter Höltje, Kirstin Jöhren
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Lack of m2 muscarinic acetylcholine receptor mRNA in rat lymphocytes

Journal of Neuroimmunology, 1994
The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype.
Costa, P, Castoldi, A. F, Traver, D. J, Costa, L. G.   +3 more
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The optimization of a novel selective antagonist for human M2 muscarinic acetylcholine receptor

Bioorganic & Medicinal Chemistry Letters, 2020
Muscarinic acetylcholine receptors (mAChRs) comprise five distinct subtypes denoted M1 to M5. The antagonism of M2 subtype could increase the release of acetylcholine from vesicles into the synaptic cleft and improve postsynaptic functions in the hippocampus via M1 receptor activation, displaying therapeutic potentials for Alzheimer's disease. However,
Zhoumi Hu, Chen Huang, Hao Wang, Lan-Xue Zhao, Hongzhuan Chen, Lina Hou, Dewei Tang, Fan Ding, Li Miaomiao, Wu Xingyu, Yan Zhu, Jian-Rong Xu, Jian-Rong Xu   +12 more
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Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors

Biochemical Pharmacology, 1996
Muscarinic receptors of the m2 subtype expressed in Chinese hamster ovary cells were labeled with [methyl-3H]acetylcholine([3H]ACh), and the rate of dissociation in the presence and absence of several compounds known to exert allosteric effects on labeled antagonist binding was observed.
Ann L. Gnagey, John Ellis, John Ellis
openaire   +3 more sources