Results 211 to 220 of about 15,825 (259)

Comparative in vitro and in silico evaluation of the toxic effects of metformin and/or ascorbic acid, new treatment options in the treatment of Melasma. [PDF]

Toxicol Res (Camb)
Yalçın HT, Çakır DA, Yirün A, Sanajou S, Işık G, Bozdemir Ö, Özçelik İ, Güdül Bacanlı M, Zeybek ND, Baydar T, Erkekoğlu P.   +10 more
europepmc   +1 more source

Cholinesterase and Inflammation: Exploring Its Role and Associations with Inflammatory Markers in Patients with Lower Extremity Artery Disease. [PDF]

Biomedicines
Mitteregger M, Steiner S, Willfort-Ehringer A, Gremmel T, Koppensteiner R, Gschwandtner M, Ritter-Hobl EL, Kopp CW, Wadowski PP.   +8 more
europepmc   +1 more source

Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models. [PDF]

Transl Neurodegener
Power SK, Venkatesan S, Qu S, McLaurin J, Lambe EK.   +4 more
europepmc   +1 more source

Characteristics of Cerebrovascular Response to Intrinsic Vasoactive Substances in Sika Deer (Cervus nippon yesoensis) and the Possible Effects of Gravity on Adrenergic Responses. [PDF]

Animals (Basel)
Islam MZ, Wu S, Ootawa T, Smith H, Nguyen HTT, Harada E, Miyamoto A.   +6 more
europepmc   +1 more source

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A model of the human M2 muscarinic acetylcholine receptor

Journal of Computer-Aided Molecular Design, 2002
The M2 muscarinic acetylcholine receptor belongs to the family of rhodopsin like G-Protein Coupled Receptors. This subtype of muscarinic receptors is of special interest because it bears, aside from an orthosteric binding site, also an allosteric binding site.
Hans-Dieter Höltje, Kirstin Jöhren
openaire   +3 more sources

Lack of m2 muscarinic acetylcholine receptor mRNA in rat lymphocytes

Journal of Neuroimmunology, 1994
The presence of muscarinic acetylcholine receptors on lymphocytes has been demonstrated by radioligand binding experiments. Although the specific subtype(s) of muscarinic acetylcholine receptors expressed in lymphocytes is still unknown, some reports suggest the presence of the m2 subtype.
Costa, P, Castoldi, A. F, Traver, D. J, Costa, L. G.   +3 more
openaire   +3 more sources

The optimization of a novel selective antagonist for human M2 muscarinic acetylcholine receptor

Bioorganic & Medicinal Chemistry Letters, 2020
Muscarinic acetylcholine receptors (mAChRs) comprise five distinct subtypes denoted M1 to M5. The antagonism of M2 subtype could increase the release of acetylcholine from vesicles into the synaptic cleft and improve postsynaptic functions in the hippocampus via M1 receptor activation, displaying therapeutic potentials for Alzheimer's disease. However,
Zhoumi Hu, Chen Huang, Hao Wang, Lan-Xue Zhao, Hongzhuan Chen, Lina Hou, Dewei Tang, Fan Ding, Li Miaomiao, Wu Xingyu, Yan Zhu, Jian-Rong Xu, Jian-Rong Xu   +12 more
openaire   +2 more sources

Allosteric regulation of the binding of [3H]acetylcholine to m2 muscarinic receptors

Biochemical Pharmacology, 1996
Muscarinic receptors of the m2 subtype expressed in Chinese hamster ovary cells were labeled with [methyl-3H]acetylcholine([3H]ACh), and the rate of dissociation in the presence and absence of several compounds known to exert allosteric effects on labeled antagonist binding was observed.
Ann L. Gnagey, John Ellis, John Ellis
openaire   +3 more sources