Results 101 to 110 of about 13,362 (255)

Colorectal Neoplasia Pathogenesis in Normal Appearing Colonic Mucosa ‐A Perspective With Focus on Eicosanoid Signaling Pathways

Cancer Medicine, Volume 14, Issue 18, September 2025.
ABSTRACT Colorectal cancer (CRC) is a major cause of cancer‐related mortality, especially in the Western world, and its incidence is expected to increase in the years to come. Prevention and early detection are key strategies to improve CRC morbidity and mortality.
Ulrike Ries Feddersen, Sebastian Kjærgaard Hendel, Victoria Hellen Berner‐Hansen, Simon Veedfald, Mark Berner‐Hansen, Niels Bindslev   +5 more
wiley   +1 more source

Influence of nano-TiO2 on functioning of gastric smooth muscles: in vitro and in silico studies

Біологічні студії, 2019
Nanosized materials, including titanium dioxide nanoparticles, sized under 10 nm, are systems with an excessive energy and high chemical activity, while the nanopartic­les of about (1–3) nm enter the reactions with other chemical compounds practically ...
O. V. Tsymbalyuk, A. M. Naumenko, T. L. Davydovska   +2 more
doaj   +1 more source

Cell-Type Specific Neuromodulation of Excitatory and Inhibitory Neurons via Muscarinic Acetylcholine Receptors in Layer 4 of Rat Barrel Cortex

Frontiers in Neural Circuits, 2022
The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention, vigilance, learning and memory. ACh is released during different behavioural states and affects the brain microcircuit by regulating neuronal and synaptic properties ...
Guanxiao Qi, Dirk Feldmeyer, Dirk Feldmeyer, Dirk Feldmeyer   +3 more
doaj   +1 more source

Central Pattern Generators in Spinal Cord Injury: Mechanisms, Modulation, and Therapeutic Strategies for Motor Recovery

JOR SPINE, Volume 8, Issue 3, September 2025.
This study explores the role of Central Pattern Generators (CPGs) in locomotor recovery after spinal cord injury (SCI). It examines CPG organization, function, and modulation through amino acids, biogenic amines, and acetylcholine. Therapeutic strategies, including pharmacological, electrical, and optogenetic approaches, are reviewed, alongside current
Hao Su, Longfei Jing, Dongmei Lv, Zhendong Huan, Wenqiang Xu   +4 more
wiley   +1 more source

Pancreatic Islet Cell Hormones: Secretion, Function, and Diabetes Therapy

MedComm, Volume 6, Issue 9, September 2025.
The pancreatic islets, composed of α, β, δ, ε, and PP cells, play a central role in maintaining glucose homeostasis. This review examines the mechanisms of islet hormone secretion and their functional crosstalk networks, alongside the pathophysiology of diabetes driven by hormonal dysregulation.
Jinfang Ma, Mao Li, Lingxiao Yang, Qingxing Xie, Rongping Fan, Xi Lu, Xing Huang, Nanwei Tong, Zhenyu Duan   +8 more
wiley   +1 more source

Autoantibodies to muscarinic acetylcholine receptors found in patients with primary biliary cirrhosis

BMC Gastroenterology, 2010
Background Autoantibodies to the human muscarinic acetylcholine receptor of the M3 type (hmAchR M3) have been suggested to play an etiopathogenic role in Sjögren's syndrome.
Berg Peter A, Gregor Michael, Lauber Kirsten, Blume Karin, Berg Christoph P, Wesselborg Sebastian, Stein Gerburg M   +6 more
doaj   +1 more source

The Clinical Significance of the Subtypes of Detrusor Overactivity: A Systematic Review

Neurourology and Urodynamics, Volume 44, Issue 7, Page 1484-1490, September 2025.
ABSTRACT Introduction Detrusor overactivity (DO) is the “occurrence of detrusor contraction(s) during filling cystometry” [7] and can be “phasic” or “terminal” [26]. The aim of this systematic review was to establish whether there is any clinical significance between the different subtypes of DO in terms of demographics, underlying pathophysiology ...
Manisha Teji, Nicholas Raison, Nicholas Faure‐Walker   +2 more
wiley   +1 more source

Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms

Frontiers in Cellular Neuroscience, 2019
In hippocampal CA1, muscarinic acetylcholine (ACh) receptor (mAChR) activation via exogenous application of cholinergic agonists has been shown to presynaptically inhibit Schaffer collateral (SC) glutamatergic inputs in stratum radiatum (SR), and ...
Priyodarshan Goswamee, A. Rory McQuiston
doaj   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

Beyond the Surface: Investigating the Potential Mechanisms of Non‐Motor Symptoms in Myasthenia Gravis

European Journal of Neurology, Volume 32, Issue 8, August 2025.
We review the non‐motor symptoms of MG and their potential pathogenesis, hoping to contribute to personalized diagnosis and treatment. ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder affecting the neuromuscular junction (NMJ), driven by T cells, mediated by B cells, and dependent on autoantibodies.
Benqiao Wang, Dan Liu, Yingying Yang, Ruixia Zhu   +3 more
wiley   +1 more source