Results 101 to 110 of about 27,064 (276)

Functional M₃ muscarinic acetylcholine receptors in mammalian hearts [PDF]

British Journal of Pharmacology, 2004
In contrast to most peripheral tissues where multiple subtypes of muscarinic acetylcholine receptor (mAChR) coexist, with each of them playing its part in the orchestra of parasympathetic innervation, the myocardium has been traditionally considered to possess a single mAChR subtype.
Zhiguo, Wang, Hong, Shi, Huizhen, Wang
openaire   +2 more sources

Direct modulation of TRPC ion channels by Gα proteins

Frontiers in Physiology
GPCR-Gi protein pathways are involved in the regulation of vagus muscarinic pathway under physiological conditions and are closely associated with the regulation of internal visceral organs.
Hana Kang, Jinhyeong Kim, Christine Haewon Park, Byeongseok Jeong, Insuk So   +4 more
doaj   +1 more source

The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection.

PLoS Pathogens, 2015
Innate immunity is regulated by cholinergic signalling through nicotinic acetylcholine receptors. We show here that signalling through the M3 muscarinic acetylcholine receptor (M3R) plays an important role in adaptive immunity to both Nippostrongylus ...
Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Jane Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F Cunningham, Frank Brombacher, Murray E Selkirk, William G C Horsnell   +11 more
doaj   +1 more source

Acetylcholine Receptor Stimulation Activates Protein Kinase C Mediated Internalization of the Dopamine Transporter

Frontiers in Cellular Neuroscience, 2021
The dopamine transporter (DAT) clears neurotransmitters from the extracellular space and serves as an important regulator of signal amplitude and duration at sites of dopamine release. Several different intracellular signaling pathways have been observed
Suzanne M. Underhill, Susan G. Amara
doaj   +1 more source

Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast [PDF]

Journal of Biological Chemistry, 2003
Clarice Schmidt, Bo Li, Lanh M. Bloodworth, Isolde Erlenbach, Fu‐Yue Zeng, Jürgen Wess   +5 more
openalex   +2 more sources

Neurons in a Dish: A Review of In Vitro Cell Models for Studying Neurogenesis

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Different in vitro cell models are valuable to study the different steps of neurogenesis, from the proliferation of neural stem and progenitor cells to the maturation of neurons. Pluripotent stem cells (including embryonic stem cells and induced pluripotent stem cells), immortalized human neuroblastoma cell lines (SH‐SY5Y, IMR‐32), and primary brain ...
Mariana Vassal, Ana C. Cruz, Sandra Rebelo, Filipa Martins   +3 more
wiley   +1 more source

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts

Brain, Behavior, & Immunity - Health, 2020
Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist   +5 more
doaj   +1 more source

Evaluation of the gastrointestinal anti-motility effect of Anacardium occidentale stem bark extract: A mechanistic study of antidiarrheal activity

Journal of Pharmaceutical Analysis, 2021
Diarrhea is a prevalent gastrointestinal problem associated with fatal implications. It is a huge public health concern that requires better alternatives to current drugs.
Blessing O. Omolaso, Francis S. Oluwole, Olugbenga A. Odukanmi, Julius K. Adesanwo, Ahmed A. Ishola, Kayode E. Adewole   +5 more
doaj   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, Volume 15, Issue 12, Page 1955-1962, December 2025.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Effects of Different Photoperiods on Growth Performance, Glucose Metabolism, Acetylcholine, and Its Relative Acetylcholine Receptor Modulation in Broiler Chickens

Animals
Photoperiods are crucial environmental factors in the growth and health of modern intensive broiler chicken production. To date, the effects of different photoperiods on glucose metabolism, acetylcholine (ACh), and its relative acetylcholine receptor ...
Miao Yu, Mengjie Xu, Guangju Wang, Jinghai Feng, Minhong Zhang   +4 more
doaj   +1 more source