Results 131 to 140 of about 28,480 (301)

Neuroimmune interactions: The bridge between inflammatory bowel disease and the gut microbiota

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
The gut microbiota regulates the gut–brain–immune axis, modulating neuroimmune interactions in inflammatory bowel disease (IBD). Microbiota‐derived metabolites influence immune cells, driving cytokine release that activates dorsal root ganglion (DRG) neurons.
Jinxia Zhai, Yingjie Li, Jiameng Liu, Cong Dai   +3 more
wiley   +1 more source

Cholinergic Regulation of Orexin/Hypocretin Neurons Through M3Muscarinic Receptor in Mice

Journal of Pharmacological Sciences, 2008
The cholinergic system plays an important role in regulation of arousal and REM sleep. In the present study, we showed that a muscarinic receptor agonist, carbachol (CCh), activates almost 20% of orexin-producing neurons (orexin neurons), which play a ...
Kousaku Ohno, Mari Hondo, Takeshi Sakurai   +2 more
doaj  

Can the Bladder Itself “Measure” Volume, and Thereby Help to Determine When Initiation of Voiding Should Occur? ICI‐RS 2024

Neurourology and Urodynamics, Volume 44, Issue 3, Page 568-576, March 2025.
ABSTRACT Aims To answer the question of whether the bladder itself can to any extent control or modulate the initiation of voiding. Methods This subject was discussed at the International Consultation on Incontinence‐Research Society (ICI‐RS) 2024 conference in Bristol, UK in a proposal session.
Gommert Van Koeveringe, Karen D. McCloskey, Anthony J. Kanai, Mathijs M. de Rijk, Pradeep Tyagi, John E. Speich, Christopher H. Fry, Alan J. Wein   +7 more
wiley   +1 more source

A physical model of nicotinic ACh receptor kinetics [PDF]

arXiv, 2008
We present a new approach to nicotinic receptor kinetics and a new model explaining random variabilities in the duration of open events. The model gives new interpretation on brief and long receptor openings and predicts (for two identical binding sites) the presence of three components in the open time distribution: two brief and a long.
arxiv  

Novel aspects of cholinergic regulation of colonic ion transport [PDF]

, 2015
Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core   +1 more source

The Channel Capacity of Channelrhodopsin and Other Intensity-Driven Signal Transduction Receptors [PDF]

arXiv, 2018
Biological systems transduce signals from their surroundings through a myriad of pathways. In this paper, we describe signal transduction as a communication system: the signal transduction receptor acts as the receiver in this system, and can be modeled as a finite-state Markov chain with transition rates governed by the input signal.
arxiv  

Virtual Affinity Fingerprints for Target Fishing: A New Application of Drug Profile Matching [PDF]

, 2013
We recently introduced Drug Profile Matching (DPM), a novel virtual affinity fingerprinting bioactivity prediction method. DPM is based on the docking profiles of ca.
Czobor, P., Hári, P., Jelinek, B., Málnási Csizmadia, András, Peragovics, Á., Simon, Z., Tombor, L.   +6 more
core   +1 more source

Synergistic Antiemetic Effects of Nerolidol on Domperidone, Hyoscine, and Ondansetron: In Vivo and in Silico Investigations on Receptor Binding Affinity

ChemistryOpen, Volume 14, Issue 3, March 2025.
Nerolidol shows prominent antiemetic activity and mitigates CuSO4.H2O‐mediated retching in chicks efficiently through its peripheral action. Additionally, the in silico studies have also shown possible antiemetic effects with greater binding affinity against muscarinic (specially, M2 and M3) and dopaminergic receptors.
Sharmita Ghosh Situ, Md. Shimul Bhuia, Raihan Chowdhury, Sakib Al Hasan, Siddique Akber Ansari, Irfan Aamer Ansari, Arman Ali, Muhammad Torequl Islam   +7 more
wiley   +1 more source

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj  

Untangling direct and domain-mediated interactions between nicotinic acetylcholine receptors in DHA-rich membranes [PDF]

arXiv, 2019
At the neuromuscular junction (NMJ), the nicotinic acetylcholine receptor (nAChR) self-associates to give rise to rapid muscle movement. While lipid domains have maintained nAChR aggregates in-vitro, their specific roles in nAChR clustering are currently unknown. In the present study, we carried out coarse-grained molecular dynamics simulations (CG-MD)
arxiv