Results 131 to 140 of about 13,431 (223)

Integrating the inputs that shape pancreatic islet hormone release. [PDF]

open access: yes, 2019
The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and their support cells, which together tightly control blood glucose homeostasis.
Huising, Mark O, Noguchi, Glyn M
core  

Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice

open access: yesScientific Reports
Target identification is a crucial step in elucidating the mechanisms by which functional food components exert their functions. Here, we identified the G-protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) as a target of the triterpenoid ...
Chisato Tanaka   +12 more
doaj   +1 more source

Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors. [PDF]

open access: yes, 2011
BACKGROUND: Enteric neurotransmitters that act at G protein-coupled receptors (GPCRs) are well known to acutely promote epithelial Cl(-) and fluid secretion.
Bertelsen, Lone S   +6 more
core   +1 more source

The relaxant effect of Ferula assafoetida on smooth muscles and the possible mechanisms [PDF]

open access: yes, 2015
Asafoetida (Ferula asafoetida) an oleo-gum-resin belongs to the Apiaceae family which obtained from the living underground rhizome or tap roots of the plant. F.
Boskabady, M.H., Khazdair, M.R.
core  

Understanding the Muscarinic Acetylcholine M3 Receptor: Structure, Function, and Therapeutic Implications

open access: yesInternational Journal of Biomedical Science
Muscarinic acetylcholine M receptors (mAChRs) belong to the G protein-coupled receptor (GPCR) superfamily and play a crucial role in regulating and controlling the release of acetylcholine (ACh). This review aims to focus on M3 receptor (M3R) subtype distribution, function, efficacy, and clinical applications.
Shi-wan-er Chen, Jie Wu
openaire   +1 more source

Ligand-Induced Activation of the M3-Muscarinic Acetylcholine Receptor

open access: yes
This thesis explores the computer-aided drug design of the M3-muscarinic acetylcholine receptor in three chapters. The first chapter focuses on molecular docking to identify novel agonists using the ZINC12 library. A model of the M3 receptor was built based on the M2 receptor.
openaire   +1 more source

Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma [PDF]

open access: yes, 2020
Chess-Williams, Russ   +3 more
core   +1 more source

)Molecular mechanism of Sjogren’s syndrome : Immune response to M3R [PDF]

open access: yes, 2009
課題番号 ...
スミダ タカユキ, 住田 孝之
core  

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