Effects of Nerve Growth Factor shRNA Inhibition on Asthma Phenotypes in a Mouse Model of Asthma
Nerve growth factor (NGF) plays an important role in airway hyper-responsiveness (AHR). In this study, we aimed at investigating the effect of NGF inhibition on AHR and other asthma phenotypes in a mouse model of asthma.
Jinhong Wu+3 more
doaj
Identification of a Basolateral Sorting Signal for the M3 Muscarinic Acetylcholine Receptor in Madin-Darby Canine Kidney Cells [PDF]
Laurie S. Nadler+2 more
openalex +1 more source
The human M3 muscarinic acetylcholine receptor (M3R) regulates many important physiological roles in the central and peripheral nervous systems, and it is involved in the pathophysiology of several neurodegenerative and autoimmune diseases, representing attractive potential pharmacological target for intervention.
openaire +4 more sources
Growth inhibition by the muscarinic M3 acetylcholine receptor: evidence for p21Cip1/Waf1 involvement in G1 arrest [PDF]
D. Burdon+3 more
openalex +1 more source
Random Mutagenesis of the M3 Muscarinic Acetylcholine Receptor Expressed in Yeast [PDF]
Bo Li+6 more
openalex +1 more source
Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors [PDF]
Vladislav Bugay+9 more
openalex +1 more source
Pronounced Conformational Changes following Agonist Activation of the M3 Muscarinic Acetylcholine Receptor [PDF]
Sung‐Jun Han+7 more
openalex +1 more source
Identification and Structural Determination of the M3 Muscarinic Acetylcholine Receptor Basolateral Sorting Signal [PDF]
Heidi A. Iverson+4 more
openalex +1 more source
Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors. [PDF]
BACKGROUND: Enteric neurotransmitters that act at G protein-coupled receptors (GPCRs) are well known to acutely promote epithelial Cl(-) and fluid secretion.
Bertelsen, Lone S+6 more
core +1 more source
Five muscarinic acetylcholine (mACh) receptor subtypes are divided into two classes: the M1 class (M1, M3, and M5) and the M2 class (M2 and M4). The former is coupled to Gq proteins, while the latter is coupled to Gi/o proteins.
Li-Min Mao+4 more
doaj +1 more source