Results 71 to 80 of about 27,064 (276)

Metformin Improves Autonomic Nervous System Imbalance and Metabolic Dysfunction in Monosodium L-Glutamate-Treated Rats

Frontiers in Endocrinology, 2021
Metformin is an antidiabetic drug used for the treatment of diabetes and metabolic diseases. Imbalance in the autonomic nervous system (ANS) is associated with metabolic diseases.
Claudinéia Conationi da Silva Franco, Carina Previate, Amanda Bianchi Trombini, Rosiane Aparecida Miranda, Luiz Felipe Barella, Lucas Paulo Jacinto Saavedra, Júlio Cezar de Oliveira, Kelly Valério Prates, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Audrei Pavanello, Ananda Malta, Isabela Peixoto Martins, Veridiana Motta Moreira, Camila Cristina Ianoni Matiusso, Flávio Andrade Francisco, Vander Silva Alves, Ana Maria Praxedes de Moraes, Juliane Rocha de Sant Anna, Marialba Avezum Alves de Castro Prado, Rodrigo Mello Gomes, Elaine Vieira, Paulo Cezar de Freitas Mathias   +22 more
doaj   +1 more source

Muscarinic receptor oligomerization [PDF]

, 2018
G protein-coupled receptors (GPCRs) have been classically described as monomeric entities that function by binding in a 1:1 stoichiometric ratio to both ligand and downstream signalling proteins.
Alvarez-Curto, Elisa, Marsango, Sara, Milligan, Graeme, Ward, Richard J.   +3 more
core   +1 more source

Activation State of the M3 Muscarinic Acetylcholine Receptor Modulates Mammalian Odorant Receptor Signaling [PDF]

Science Signaling, 2011
Crosstalk between neurotransmitter signaling and odorant signaling may enhance the sense of smell.
Yun Rose, Li, Hiroaki, Matsunami
openaire   +2 more sources

Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs [PDF]

, 2016
Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands is unknown.
Godin, Antoine G., Marsango, Sara, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +4 more
core   +1 more source

Macrophage TNF-α mediates parathion-induced airway hyperreactivity in guinea pigs. [PDF]

, 2013
Organophosphorus pesticides (OPs) are implicated in human asthma. We previously demonstrated that, at concentrations that do not inhibit acetylcholinesterase activity, the OP parathion causes airway hyperreactivity in guinea pigs as a result of ...
Allison D. Fryer, Becky J. Proskocil, Borish L, Crain EF, Crinnion WJ, David B. Jacoby, Donald A. Bruun, Gallo MA, Grodzki AC, Lu C, Nico van Rooijen, Pamela J. Lein, Rozyk KJ   +12 more
core   +1 more source

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Neurotherapeutics, 2022
Rett syndrome (RTT) is a neurodevelopmental disorder that is characterized by developmental regression, loss of communicative ability, stereotyped hand wringing, cognitive impairment, and central apneas, among many other symptoms.
Mackenzie Smith, Bright Arthur, Jakub J Cikowski, Calista Holt, S. González, Nicole M. Fisher, S. Vermudez, C. Lindsley, C. Niswender, Rocco G. Gogliotti   +9 more
semanticscholar   +1 more source

Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]

, 2015
Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert, Hodges, Matthew, Miller, Justin Robert, Muere, Clarissa, Neumueller, Suzanne, Olesiak, Samantha, Pan, Lawrence   +6 more
core   +2 more sources

Blockage of Cholinergic Signaling via Muscarinic Acetylcholine Receptor 3 Inhibits Tumor Growth in Human Colorectal Adenocarcinoma

Cancers, 2021
Simple Summary Darifenacin is a selective muscarinic acetylcholine receptor 3 (M3R) antagonist in clinical use for benign bladder disorders. Here, the effects of M3R blockage by darifenacin on human colon adenocarcinoma cells are analyzed in vitro and in
N. Hering, Verena Liu, Rayoung Kim, B. Weixler, R. Droeser, M. Arndt, I. Pozios, Katharina Beyer, M. Kreis, H. Seeliger   +9 more
semanticscholar   +1 more source

Calcium Mobilization by Activation of M3/M5 Muscarinic Receptors in the Human Retinoblastoma

Journal of Pharmacological Sciences, 2007
Activation of muscarinic acetylcholine receptors (mAChR) is one of the most important signal transduction pathways in the human body. In this study, we investigated the role of mAChR activation in relation to its subtypes in human retinoblastoma cell ...
Dae-Ran Kim, Sang Hoon Rah, Joon Hyung Sohn, Byung-Il Yeh, Chang Mann Ko, Jeong Sook Park, Min-Jeong Kim, Joong Woo Lee, In Deok Kong   +8 more
doaj   +1 more source

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source