Results 91 to 100 of about 15,215 (194)

Characterization of novel selective positive allosteric modulators (PAMS) of the M4 muscarinic acetylcholine receptor (mAChR)

The FASEB Journal, 2008
Resent clinical studies have revealed that the M 1 /M 4 preferring mAChR agonist xanomeline induces a robust antipsychotic effect in schizophrenic patients, suggesting that mAChR agonists may be efficacious in reducing psychotic symptoms in patients ...
Ashley Elizabeth Brady, Tom M Bridges, Carrie K Jones, Jana K Shirey, Craig W Lindsley, P Jeffrey Conn   +5 more
openaire   +1 more source

Modulation of large rhythmic depolarizations in human large basket cells by norepinephrine and acetylcholine

Communications Biology
Rhythmic brain activity is critical to many brain functions and is sensitive to neuromodulation, but so far very few studies have investigated this activity on the cellular level in vitro in human brain tissue samples.
Danqing Yang, Guanxiao Qi, Jonas Ort, Victoria Witzig, Aniella Bak, Daniel Delev, Henner Koch, Dirk Feldmeyer   +7 more
doaj   +1 more source

Clozapine is responsible for the in vivo imaging and pharmacological effects of clozapine-N-oxide in murine DREADD models

Frontiers in Pharmacology
Although clozapine-N-oxide (CNO), a major metabolite of clozapine (CLZ), is a widely used agonist of designer receptors exclusively activated by designer drugs (DREADDs), the compound responsible for visualizing or activating DREADDs in nuclear medicine ...
Jian Wang, Jian Wang, Jian Wang, Jiale Qin, Katsushi Kumata, Ming-Rong Zhang, Jun Qian, Jun Qian, Jun Qian, Wen Zhou, Bin Ji, Bin Ji, Bin Ji, Bin Ji, Bin Ji   +14 more
doaj   +1 more source

Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor [PDF]

ACS Medicinal Chemistry Letters, 2017
openaire   +4 more sources

555. M4 MUSCARINIC RECEPTOR ACTIVATION IN THE CENTRAL AMYGDALA REDUCES STRESS-INDUCED ALCOHOL SEEKING IN ALCOHOL PREFERRING RATS [PDF]

Int J Neuropsychopharmacol
Background Stress is a key factor contributing to relapse, a major hurdle in the treatment of alcohol use disorders. A region key to brain stress systems and essential for emotional regulation is the central amygdala, and alcohol dependence has been ...
R. Anversa, K. Huckstep, L. Walker, A. Lawrence   +3 more
europepmc   +2 more sources

Muscarinic acetylcholine receptor M4 (CHRM4; HM4) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

In vitro evaluation of PET radiotracers for imaging synaptic density, the acetylcholine transporter, AMPA-tarp-γ8 and muscarinic M4 receptors in Alzheimer's disease.

American Journal of Nuclear Medicine and Molecular Imaging
Several therapeutics and biomarkers that target Alzheimer's disease (AD) are under development. Our clinical positron emission tomography (PET) research programs are interested in six radiopharmaceuticals to image patients with AD and related dementias ...
Faustine d'Orchymont, Andrea Narváez, Roger Raymond, P. Sachdev, Arnaud Charil, Stephen Krause, Neil Vasdev   +6 more
semanticscholar   +1 more source

From schizophrenia to dementia: Is Cobenfy a potential treatment for behavioral and psychological symptoms of dementia? [PDF]

J Int Med Res
Golden JC, Murphy KS, Tampi RR.
europepmc   +1 more source

Targeting disrupted networks in schizophrenia: Can muscarinic drugs make a fundamental difference? [PDF]

J Psychopharmacol
Pratt JA, Morris BJ.
europepmc   +1 more source

An SstI polymorphism for the human muscarinic acetylchoilne receptor gene, m4 (CHRM 4)

Nucleic Acids Research, 1989
S D, Detera-Wadleigh, D, Wiesch, T I, Bonner   +2 more
openaire   +3 more sources