Results 101 to 110 of about 18,462 (237)

Hippocampal Inhibitory Interneuron‐Specific DREADDs Treatment Alters mTORC1‐4E‐BP Signaling and Impairs Memory Formation

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
We used advanced tools called DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to control the activity of inhibitory neurons versus excitatory neurons in the hippocampus, a region of the brain critical for learning and memory. By activating or inactivating these neurons after training, we found that disrupting their normal activity ...
Ziying Huang, Niaz Mahmood, Jean‐Claude Lacaille, Shane Wiebe, Nahum Sonenberg   +4 more
wiley   +1 more source

Cognitive improvement via cortical cannabinoid receptors and choline‐containing lipids

British Journal of Pharmacology, Volume 182, Issue 4, Page 1038-1058, February 2025.
Background and Purpose Recent research linking choline‐containing lipids to degeneration of basal forebrain cholinergic neurons in neuropathological states illustrates the challenge of balancing lipid integrity with optimal acetylcholine levels, essential for memory preservation.
Marta Moreno‐Rodríguez, Jonatan Martínez‐Gardeazabal, Iker Bengoetxea de Tena, Alberto Llorente‐Ovejero, Laura Lombardero, Estibaliz González de San Román, Lydia Giménez‐Llort, Iván Manuel, Rafael Rodríguez‐Puertas   +8 more
wiley   +1 more source

Autoantibodies against muscarinic receptors in breast cancer. Its role in tumor angiogenesis. [PDF]

, 2013
The presence of autoantibodies in cancer has become relevant in recent years. We demonstrated that autoantibodies purified from the sera of breast cancer patients activate muscarinic acetylcholine receptors in tumor cells.
Azar, María Eugenia, Castro, Maria Ester, Cresta Morgado Carlos, Fiszman, Gabriel Leon, Lombardi, Maria Gabriela, Negroni, María Pía, Pelegrina, Laura Tatiana, Sales Maria Elena   +7 more
core   +1 more source

Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet‐Induced Release of Melanosome in Cultured Melanoma Cells

Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.
Schematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Maggie Suisui Guo, Qiyun Wu, Yingjie Xia, Jiahui Wu, Xiaoyang Wang, Gary Ka Wing Yuen, Tina Tingxia Dong, Jin Gao, Karl Wah Keung Tsim   +8 more
wiley   +1 more source

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit [PDF]

, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Acsády, Ahumada, Aizawa, Akam, Alkondon, Andrade, Andrade, Aznar, Bacon, Barnes, Beck, Berumen, Bijak, Bliss, Bombardi, Brandalise, Bronzino, Buchanan, Bush, Cezar M. Tigaret, Chalmers, Chandler, Cheng, Chiang, Contractor, Cox, Danielson, Dasari, Domínguez, Domínguez, Donato, Etter, Fabian-Fine, Fischer, Frazier, Freund, Fuhs, Fukudome, Gahring, Gahring, Gangarossa, Gasbarri, Gasbarri, Gelinas, Gelinas, Giessel, Ginsberg, Giocomo, Goutagny, Gray, Griffith, Grishin, Grishin, Grybko, Grybko, Gulyás, Gundlfinger, Gundlfinger, Guo, Guzman, Haas, Haas, Hamilton, Hansen, Hansen, Hasselmo, Hasselmo, Hebb, Hofmann, Hofmann, Hofmann, Hopkins, Hopkins, Hu, Huang, Hummos, Hunsaker, Hunsaker, Hájos, Hörtnagl, Jack R. Mellor, Jacobs, Jerman, Jochems, Jochems, John, Jones, Jung, Jurgens, Karunakaran, Katsuki, Kheirbek, Kitt, Kobayashi, Kobayashi, Kobayashi, Kobayashi, Kulla, Kunec, Kwon, Lacaille, Lee, Lemon, Lengyel, Lengyel, Leranth, Leutgeb, Levey, Li, Liotta, Lisman, Lisman, Losonczy, Luke Y. Prince, Luo, Lynch, Lüscher, Maccaferri, Madison, Madison, Maeda, Manuel-Apolinar, Marr, Martinello, Marín-Burgin, McHugh, McIntyre, McMahon, McNaughton, McQuiston, Meeter, Meeter, Millan, Milner, Milner, Mishra, Missale, Mistry, Miyawaki, Mlinar, Mohler, Mori, Mori, Müller, Nahir, Nakashiba, Nakashiba, Nakazawa, Nissen, Nolan, Nozaki, O'Reilly, Okuhara, Ondrejcak, Parfitt, Parfitt, Pazos, Pedarzani, Pelkey, Piguet, Puighermanal, Radcliffe, Ramos, Restivo, Romo-Parra, Rosen, Ruediger, Ruiz, Rüdiger, Salin, Sara, Saravanan, Sariñana, Savin, Scanziani, Scanziani, Scoville, Segal, Sharma, Sharma, Smith, Sodickson, Son, Squire, Straube, Suwa, Szabadics, Szabó, Takeuchi, Tang, Tigaret, Torborg, Toth, Travis J. Bacon, Treves, Treviño, Twarkowski, Tzounopoulos, Törk, Ul Haq, Ul Haq, Vankov, Varga, Vilaró, Vilaró, Villani, Vogels, Vogt, Walling, Walling, Wang, Welsby, Welsby, West, Wiescholleck, Wilke, Williams, Williams, Yang, Yi, Zalutsky, Zhang   +221 more
core   +4 more sources

The Possible Mechanistic Basis of Individual Susceptibility to Spike Protein Injury

Advances in Virology, Volume 2025, Issue 1, 2025.
Injury from spike protein, whether induced by COVID‐19 infection or vaccination, constitutes a significant health concern for numerous individuals. Considerable heterogeneity exists in individual responses to both COVID‐19 infection and vaccination, despite the latter being principally more controlled and consistent than the wide variety of infection ...
Matthew Halma, Paola Vottero, James Thorp, Tina Peers, Jack Tuszynski, Paul Marik, Jasbir Arora   +6 more
wiley   +1 more source

Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells [PDF]

, 2016
BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear.
Cordero, P, McKee, C, Morgan, ML, Mouraliderane, A, Nguyen, V, Oben, JA, Sigala, B, Soeda, J, Vinciguerra, M   +8 more
core  

A fast genetically encoded fluorescent sensor for faithful in vivo acetylcholine detection in mice, fish, worms and flies [PDF]

, 2020
Here we design and optimize a genetically encoded fluorescent indicator, iAChSnFR, for the ubiquitous neurotransmitter acetylcholine, based on a bacterial periplasmic binding protein.
Borden, Philip M., Fan, Chengcheng, Lester, Henry A., Rees, Douglas C., Shivange, Amol V.   +4 more
core  

The Fatal Mushroom Neurotoxin Muscarine is Released from a Harmless Phosphorylated Precursor upon Cellular Injury

Angewandte Chemie International Edition, Volume 63, Issue 52, December 20, 2024.
l‐(+)‐Muscarine is one of the most toxic mushroom metabolites. We identified its congener 4’‐phosphomuscarine in the fool's funnel and in various fiber cap mushrooms, and chemically and pharmacologically characterized this new natural product. As hydrolysis of its ester releases muscarine, our results help estimate the true toxin content of these ...
Sebastian Dörner, Felix Trottmann, Paul M. Jordan, Kai Rogge, Benjamin Bartels, Oliver Werz, Christian Hertweck, Dirk Hoffmeister   +7 more
wiley   +1 more source

Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons [PDF]

, 2002
The cholinergic system is thought to play an important role in hippocampal-dependent learning and memory. However, the mechanism of action of the cholinergic system in these actions in not well understood.
Power, JM, Sah, P
core   +2 more sources