Results 101 to 110 of about 18,227 (256)

Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review

British Journal of Pharmacology, Volume 182, Issue 7, Page 1416-1445, April 2025.
Abstract In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, when 70 new chemical entities were approved, the number of ‘orphan’ drug authorisations in 2024 (21) is ...
Stavros Topouzis, Andreas Papapetropoulos, Steve P. H. Alexander, Miriam Cortese‐Krott, Dave A. Kendall, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Mauro M. Teixeira, Nathalie Vergnolle, Xin Wang, Péter Ferdinandy   +16 more
wiley   +1 more source

Hippocampal Inhibitory Interneuron‐Specific DREADDs Treatment Alters mTORC1‐4E‐BP Signaling and Impairs Memory Formation

Journal of Neurochemistry, Volume 169, Issue 3, March 2025.
We used advanced tools called DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) to control the activity of inhibitory neurons versus excitatory neurons in the hippocampus, a region of the brain critical for learning and memory. By activating or inactivating these neurons after training, we found that disrupting their normal activity ...
Ziying Huang, Niaz Mahmood, Jean‐Claude Lacaille, Shane Wiebe, Nahum Sonenberg   +4 more
wiley   +1 more source

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj  

Structure–activity relationship of pyrazol-4-yl-pyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4

Acta Pharmaceutica Sinica B, 2023
There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor 4 (M4) in schizophrenia and dementia with Lewy bodies, however, a clinically validated M4 positron emission tomography (PET) radioligand is currently lacking.
Ahmed Haider, Xiaoyun Deng, Olivia Mastromihalis, Stefanie K. Pfister, Troels E. Jeppesen, Zhiwei Xiao, Vi Pham, Shaofa Sun, Jian Rong, Chunyu Zhao, Jiahui Chen, Yinlong Li, Theresa R. Connors, April T. Davenport, James B. Daunais, Vahid Hosseini, Wenqing Ran, Arthur Christopoulos, Lu Wang, Celine Valant, Steven H. Liang   +20 more
doaj  

Membrane Receptor-Induced Changes of the Protein Kinases A and C Activity May Play a Leading Role in Promoting Developmental Synapse Elimination at the Neuromuscular Junction

Frontiers in Molecular Neuroscience, 2017
Synapses that are overproduced during histogenesis in the nervous system are eventually lost and connectivity is refined. Membrane receptor signaling leads to activity-dependent mutual influence and competition between axons directly or with the ...
Josep M. Tomàs, Neus Garcia, Maria A. Lanuza, Laura Nadal, Marta Tomàs, Erica Hurtado, Anna Simó, Víctor Cilleros   +7 more
doaj   +1 more source

Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families. [PDF]

, 2006
The CHRM2 gene is thought to be involved in neuronal excitability, synaptic plasticity and feedback regulation of acetylcholine release and has previously been implicated in higher cognitive processing.
Boomsma D.I., Cherny S.S., D. I. Boomsma, D. Posthuma, E. J. C. de Geus, Hulme E.C., J. C. Polderman, Levey A.I., Linder C.C., M. F. Gosso, M. van Belzen, Meulenbelt I., Miller S.A., Montagutelli X., P. Heutink, Quirion R., Wechsler D., Wechsler D., Wei J., Wess J., Zhang W.   +20 more
core   +3 more sources

Cognitive improvement via cortical cannabinoid receptors and choline‐containing lipids

British Journal of Pharmacology, Volume 182, Issue 4, Page 1038-1058, February 2025.
Background and Purpose Recent research linking choline‐containing lipids to degeneration of basal forebrain cholinergic neurons in neuropathological states illustrates the challenge of balancing lipid integrity with optimal acetylcholine levels, essential for memory preservation.
Marta Moreno‐Rodríguez, Jonatan Martínez‐Gardeazabal, Iker Bengoetxea de Tena, Alberto Llorente‐Ovejero, Laura Lombardero, Estibaliz González de San Román, Lydia Giménez‐Llort, Iván Manuel, Rafael Rodríguez‐Puertas   +8 more
wiley   +1 more source

Acetylcholine induces fibrogenic effects via M2/M3 ACh receptors in NASH and in primary human hepatic stellate cells [PDF]

, 2016
BACKGROUND: The parasympathetic nervous system (PNS), via neurotransmitter Acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear.
Cordero, P, McKee, C, Morgan, ML, Mouraliderane, A, Nguyen, V, Oben, JA, Sigala, B, Soeda, J, Vinciguerra, M   +8 more
core  

Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation [PDF]

, 2015
Acetylcholine (ACh) release onto nicotinic receptors directly activates subsets of inhibitory interneurons in hippocampal CA1. However, the specific interneurons activated and their effect on the hippocampal network is not completely understood ...
Bell, Karen A., Bell, L. Andrew, McQuiston, A. Rory   +2 more
core   +3 more sources

Cholinergic Signaling Mediated by Muscarinic Receptors Triggers the Ultraviolet‐Induced Release of Melanosome in Cultured Melanoma Cells

Pigment Cell &Melanoma Research, Volume 38, Issue 1, January 2025.
Schematic diagram illustrating the role of mAChRs in UVB‐mediated melanosome release. Under UVB irradiation, the epidermal keratinocytes and melanocytes release ACh. ACh stimulates M1/M3 mAChRs and leads to activation of PLC, which thereafter increases the levels of IP3 and DAG, as well as the intracellular Ca2+ and PKC. In addition, the expressions of
Maggie Suisui Guo, Qiyun Wu, Yingjie Xia, Jiahui Wu, Xiaoyang Wang, Gary Ka Wing Yuen, Tina Tingxia Dong, Jin Gao, Karl Wah Keung Tsim   +8 more
wiley   +1 more source