Results 121 to 130 of about 18,227 (256)

Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors [PDF]

, 1995
We constructed chimeras of the rat beta 2 and beta 4 neuronal nicotinic subunits to locate the regions that contribute to differences between the acetylcholine (ACh) dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 receptors ...
Cohen, B. N., Davidson, N., Figl, A., Labarca, C., Lester, H. A., Quick, M. W.   +5 more
core   +2 more sources

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts

Brain, Behavior, & Immunity - Health, 2020
Myalgic encephalomyelitis (ME) also known as ME/CFS (Chronic Fatigue Syndrome) or ME/SEID (Systemic Exertion Intolerance Disorder), is a disabling and often long-lasting disease that can drastically impair quality of life and physical/social functioning ...
Annie Bynke, Per Julin, Carl-Gerhard Gottfries, Harald Heidecke, Carmen Scheibenbogen, Jonas Bergquist   +5 more
doaj  

Current and Future Issues in the Development of Spinal Agents for the Management of Pain. [PDF]

, 2017
Targeting analgesic drugs for spinal delivery reflects the fact that while the conscious experience of pain is mediated supraspinally, input initiated by high intensity stimuli, tissue injury and/or nerve injury is encoded at the level of the spinal ...
Fisher, Casey J, Hockman, Tyler M, Wiese, Ashley J, Yaksh, Tony L   +3 more
core   +2 more sources

Potential differences in receptor‐mediated G‐protein activation in postmortem human hippocampal membranes prepared from healthy controls and suicide victims

Neuropsychopharmacology Reports, Volume 44, Issue 4, Page 762-773, December 2024.
Functional activations of G‐proteins coupled to multiple GPCRs were determined in postmortem human hippocampal membranes. No significant differences were detected between suicide victims and controls. Abstract Aim Postmortem brain studies offer enormous opportunities to study molecular mechanisms associated with suicide.
Yuji Odagaki, Masakazu Kinoshita, Miklós Palkovits, Dasiel Oscar Borroto‐Escuela, Kjell Fuxe   +4 more
wiley   +1 more source

Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts [PDF]

, 2019
Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol (Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid-ordered microdomains (raft domains), together with saturated ...
Antollini, Silvia Susana, Fabiani, Camila   +1 more
core   +1 more source

Neuroscience in peripheral cancers: tumors hijacking nerves and neuroimmune crosstalk

MedComm, Volume 5, Issue 11, November 2024.
The figure depicts the intricate interactions between cancer cells, the immune system, and nerves within the tumor microenvironment. At the center, the diagram highlights the tripartite relationship among cancer, immune, and nerve cells, illustrating the dynamic and reciprocal influences they exert on one another.
Hua‐Yang Fan, Xin‐Hua Liang, Ya‐Ling Tang   +2 more
wiley   +1 more source

Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling [PDF]

, 2017
Satiety, rather than all or none, can instead be viewed as a cumulative decrease in the drive to eat that develops over the course of a meal. The nucleus accumbens (NAc) is known to play a critical role in this type of value reappraisal, but the ...
Aitta-aho, Teemu Heikki Juhani, Apergis-Schoute, John, Bussey, Tim J., Harnischfeger, Fiona, Hay, Y. Adrey, Heath, Christopher, Pappa, Elpiniki, Phillips, Benjamin U., Saksida, Lisa M.   +8 more
core   +2 more sources

Targeting muscarinic receptors for the treatment of alcohol use disorders: Opportunities and hurdles for clinical development

British Journal of Pharmacology, Volume 181, Issue 22, Page 4385-4398, November 2024.
Emerging evidence suggests muscarinic acetylcholine receptors represent novel targets to treat alcohol use disorder. In this review, we draw from literature across medicinal chemistry, molecular biology, addiction and learning/cognition fields to interrogate the proposition for muscarinic receptor ligands in treating various aspects of alcohol use ...
Leigh C. Walker, Kade L. Huckstep, Howard C. Becker, Christopher J. Langmead, Andrew J. Lawrence   +4 more
wiley   +1 more source

Mechanosensory stimulation evokes acute concussion-like behavior by activating GIRKs coupled to muscarinic receptors in a simple vertebrate [PDF]

, 2017
This work was supported by BBSRC (BB/L00111X).Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow.
Li, Wen-Chang, Ritson, Emma, Zhu, Xiao-Yue   +2 more
core   +2 more sources

Novel aspects of cholinergic regulation of colonic ion transport [PDF]

, 2015
Nicotinic receptors are not only expressed by excitable tissues, but have been identified in various epithelia. One aim of this study was to investigate the expression of nicotinic receptors and their involvement in the regulation of ion transport across
Bader, Sandra, Diener, Martin
core   +1 more source