Urothelium muscarinic activation phosphorylates CBS Ser227 via cGMP/PKG pathway causing human bladder relaxation through H 2 S production [PDF]
, 2016 The urothelium modulates detrusor activity through releasing factors whose nature has not been clearly defined. Here we have investigated the involvement of H2S as possible mediator released downstream following muscarinic (M) activation, by using human ...
CIRINO, GIUSEPPE +10 more
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Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]
, 2016 Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark +5 more
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Expression of functional M2 muscarinic acetylcholine receptor in Escherichia coli [PDF]
, 2000 The M2 muscarinic acetylcholine receptor mutant (M2 mutant), with a lack of glycosylation sites, a deletion in the central part of the third inner loop, and the addition of a six histidine tag at the C-terminus, was fused to maltose binding protein (MBP)
Furukawa, H., Haga, T.
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Expression of the Rat m4 Muscarinic Acetylcholine Receptor Gene Is Regulated by the Neuron-restrictive Silencer Element/Repressor Element 1 [PDF]
, 1997 Michihiro Mieda +2 more
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The Effects of Anticholinesterase Drugs on Bethanechol-İnduced Contractile Responses in Rat Ileum Smooth Muscle [PDF]
, 2007 At present, anticholinesterase drugs are valuable as therapeutic agents when cholinergic activity decreased in cases such as glokom, myastenia gravis and postoperative period which induces atony in bladder and intestinal smooth muscles.
Ilker Kelle
core
The FASEB Journal, 2013 Clinically available antipsychotics primarily treat the positive symptoms in schizophrenia, but have little or no effect on the negative symptoms or disruptions in cognition or sleep. Muscarinic cholinergic receptor (mAChR) subtypes mediate aspects of learning, memory and sleep/wakefulness. Recently, the M1/M4‐preferring mAChR agonist xanomeline showed
Michael R. Wood +9 more
openaire +2 more sources
Communications BiologyRhythmic brain activity is critical to many brain functions and is sensitive to neuromodulation, but so far very few studies have investigated this activity on the cellular level in vitro in human brain tissue samples.
Danqing Yang +7 more
doaj +1 more source
A Dopamine-Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons [PDF]
, 2007 The "teaching signal" that modulates reinforcement learning at cortico-striatal synapses may be a sequence composed of an adaptively scaled DA burst, a brief ACh burst, and a scaled ACh pause.
Bullock, Daniel, Tan, Can Ozan
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Effects of synaptotagmin reveal two distinct mechanisms of agonist‐stimulated internalization of the M4 muscarinic acetylcholine receptor [PDF]
, 2005 Michael T. Madziva +4 more
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