Results 131 to 140 of about 15,215 (194)

The Need for and Importance of Thorough and Comprehensive Studies on the Molecular Mechanisms of Action of Animal Toxins, Venoms, and Antivenoms. [PDF]

Int J Mol Sci
Kini RM, Utkin YN.
europepmc   +1 more source

Schizophrenia: Genetics, neurological mechanisms, and therapeutic approaches. [PDF]

Neural Regen Res
Lim DXE, Yeo SY, Chia ZYA, Fernandis AZ, Lee J, Chua JJE.   +5 more
europepmc   +1 more source

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A Rab10–ACAP1–Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling

Cellular and Molecular Life Sciences, 2023
Membrane trafficking processes regulate the G protein-coupled receptor activity. The muscarinic acetylcholine receptors (mAChRs) are highly pursued drug targets for neurological diseases, but the cellular machineries that control the trafficking of these receptors remain largely elusive.
Rongmei Xu, Min Wan, Xuemeng Shi, Shumin Ma, Lina Zhang, Ping Yi, Rongying Zhang   +6 more
openaire   +3 more sources

Development of Novel M4 Muscarinic Acetylcholine Receptor Antagonists for the Treatment of Movement Disorders

The FASEB Journal, 2022
Non‐selective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson’s disease and dystonia. Despite their efficacy in these and other central nervous system disorders, anti‐muscarinic therapy has ...
Jerri Rook, Aaron Bender, Jonathan Dickerson, Daniel Foster, Alice Rodriguez, Colleen Niswender, Ellen Hess, Jeff Conn, Craig Lindsley   +8 more
openaire   +2 more sources

M4-muscarinic acetylcholine receptor into the pedunculopontine tegmental nucleus mediates respiratory modulation of conscious rats

Respiratory Physiology & Neurobiology, 2019
The pedunculopontine tegmental nucleus (PPTg) has been shown to have important functions relevant to the regulation of behavioral states and various motor control systems, including breathing control. The PPTg is considered an important nucleus in the mesopontine region with considerably cholinergic input to the ventral respiratory column. In addition,
Janayna D, Lima, Cleyton R, Sobrinho, Leonardo K, Santos, Ana C, Takakura, Thiago S, Moreira   +4 more
openaire   +3 more sources

Structural and Dynamic Mechanisms of Allostery at the M4 Muscarinic Acetylcholine Receptor

SSRN Electronic Journal, 2022
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I. Mobbs, Matthew J. Belousoff, Apurba Bhattarai, Wessel A.C. Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, Katie Leach, Emma T. van der Westhuizen, Elham Khajehali, Yi-Lynn Liang, Alisa Glukhova, Denise Wootten, Craig W. Lindsley, Andrew Tobin, Patrick M. Sexton, Radostin Danev, Celine Valant, Yinglong Miao, Arthur Christopoulos, David Thal   +23 more
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Biased Profile of Xanomeline at the Recombinant Human M4 Muscarinic Acetylcholine Receptor.

ACS Chemical Neuroscience, 2022
Many Food and Drug Administration (FDA)-approved drugs are structural analogues of the endogenous (natural) ligands of G protein-coupled receptors (GPCRs).
J. Mcdonald, E. T. van der Westhuizen, Vi Pham, Geoff V. Thompson, C. Felder, S. Paul, D. Thal, A. Christopoulos, C. Valant   +8 more
semanticscholar   +1 more source

The M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) VU0453595 and M4 PAM VU0467154 Normalize Sleep‐Wake Architecture Deficits in Aged Mice

Alzheimer's & Dementia, 2022
Declining basal forebrain cholinergic integrity has been associated with disturbances in sleep‐wake architecture in Alzheimer’s Disease (AD). Acetylcholinesterase inhibitors (AChEIs) provide symptomatic treatment for the cognitive deficits in AD through ...
Jason K. Russell, M. Bubser, Shalonda M. Ingram, P. Newhouse, C. Lindsley, Carrie K Jones   +5 more
semanticscholar   +1 more source