Antipsychotic Drug-Like Effects of the Selective M4 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator VU0152100 [PDF]
Nellie Byun+20 more
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The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins [PDF]
Multiple mechanisms exist for the endocytosis of receptors from the cell surface. While the M1, M3, and M4 subtypes of muscarinic acetylcholine receptor and M4 receptors transduce their signals through the same second messengers but internalize though different pathways, we tested the ability of several small G-proteins to regulate the agonist-induced ...
Cindy Reiner, Neil M. Nathanson
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Rab5-dependent Trafficking of the m4 Muscarinic Acetylcholine Receptor to the Plasma Membrane, Early Endosomes, and Multivesicular Bodies [PDF]
The m4 subtype of muscarinic acetylcholine receptor regulates many physiological processes and is a novel therapeutic target for neurologic and psychiatric disorders. However, little is known about m4 regulation because of the lack of pharmacologically selective ligands.
Laura A. Volpicelli+2 more
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Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor. [PDF]
Robert B. Kargbo
semanticscholar +6 more sources
Crystal structures of the M1 and M4 muscarinic acetylcholine receptors [PDF]
Muscarinic M1-M5 acetylcholine receptors are G-protein-coupled receptors that regulate many vital functions of the central and peripheral nervous systems. In particular, the M1 and M4 receptor subtypes have emerged as attractive drug targets for treatments of neurological disorders, such as Alzheimer's disease and schizophrenia, but the high ...
David M. Thal+13 more
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Muscarinic acetylcholine receptor M4 (CHRM4; HM4) [PDF]
openalex +3 more sources
The central cholinergic system plays an important role in normal arousal and sleep/wake architecture, and is known to decline in non‐pathological aging and Alzheimer’s disease (AD).
Jason K. Russell+5 more
semanticscholar +1 more source
Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats. [PDF]
The present study aims to investigate the therapeutic effects of LXM-10 by intragastric administration in both acute and chronic inflammatory models, and to explore the underlying molecular mechanisms.
Weiwei Zhang+5 more
doaj +1 more source
Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice [PDF]
The reinforcing effects of cocaine are mediated by the mesolimbic dopamine system. Behavioral and neurochemical studies have shown that the cholinergic muscarinic M(4) receptor subtype plays an important role in regulation of dopaminergic neurotransmission.Here we investigated for the first time the involvement of M(4) receptors in the reinforcing ...
Lene S. Schmidt+7 more
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The M4 muscarinic acetylcholine receptor plays a key role in the control of murine hair follicle cycling and pigmentation [PDF]
Cholinergic receptors of the muscarinic class (M1-M5) are expressed in epidermal keratinocytes and melanocytes as well as in the hair follicle. Knockout (KO) mice of all five receptors have been created and resulted in different phenotypes. KO mice with a deletion of the M4 muscarinic acetylcholine receptor (M4R) present a striking hair phenotype ...
Sybille Hasse+3 more
openalex +4 more sources