Results 31 to 40 of about 15,215 (194)

Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor [PDF]

European Journal of Pharmacology, 2011
A delicate balance exists between the central dopaminergic and cholinergic neurotransmitter systems with respect to motor function. An imbalance can result in motor dysfunction as observed in Parkinson's disease patients and in patients treated with antipsychotic compounds.
Fink-Jensen, Anders, Schmidt, Lene S, Dencker, Ditte, Schülein, Christina, Wess, Jürgen, Wörtwein, Gitta, Woldbye, David Paul Drucker   +6 more
openaire   +3 more sources

New Tricks for an Old Dog: Biased GPCR Agonism of an M4 Muscarinic Acetylcholine Receptor Antagonist in Airway Smooth Muscle Cells

American Journal of Respiratory Cell and Molecular Biology, 2022
ligands, the expectation is that they will only trigger G-protein–independent pathways that promote antiremodeling and bronchorelaxant actions via b -arrestin pathways that are distinct from those driving bronchial hyperresponsiveness.
Y. Amrani
semanticscholar   +1 more source

A New Era of Muscarinic Acetylcholine Receptor Modulators in Neurological Diseases, Cancer and Drug Abuse. [PDF]

Pharmaceuticals (Basel)
The cholinergic pathways in the central nervous system (CNS) play a pivotal role in different cognitive functions of the brain, such as memory and learning.
Tsimpili H, Zoidis G.
europepmc   +2 more sources

CaMKIIα, a modulator of M4 muscarinic acetylcholine receptors

Communicative & Integrative Biology, 2010
G protein-coupled receptors (GPCRs) are subject to the regulation by protein kinases. By controlling the phosphorylation-dephosphorylation balance, protein kinases actively modify GPCR expression and function. In a recent study, we have identified a novel phosphorylation-dependent regulation of Gαi/o-coupled muscarinic acetylcholine receptors.
Ming-Lei, Guo, Zhenguo, Liu, Xiang-Ping, Chu, Li-Min, Mao, John Q, Wang   +4 more
openaire   +2 more sources

Evaluation of antipsychotic properties of M4 muscarinic acetylcholine receptor agonists in mice

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021
M 1 and/or M 4 muscarinic acetylcholine receptors are suggested to be involved in the pathogenesis and treatment of schizophrenia. To validate the antipsychotic potential of M 4 receptor activation, we evaluated the antipsychotic properties of the ...
Yumika Toyoshima, M. Nakamura, Emi Yoshida, Chifuyu Ohashi, K. Hirose, Y. Ishizaki, Yoshihiro Nakamura, Mei Higaki, S. Shimizu, T. Sumiyoshi, Y. Ohno   +10 more
semanticscholar   +1 more source

Modulation of M4 muscarinic acetylcholine receptors by interacting proteins

Neuroscience Bulletin, 2010
Protein-protein interactions represent an important mechanism for posttranslational modifications of protein expression and function. In brain cells, surface-expressed and membrane-bound neurotransmitter receptors are common proteins that undergo dynamic protein-protein interactions between their intracellular domains and submembranous regulatory ...
Ming-Lei, Guo, Li-Min, Mao, John Q, Wang
openaire   +3 more sources

Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice [PDF]

Molecular Psychiatry, 2003
Among the five different muscarinic receptors that have been cloned and characterized, M2 and M4 receptors are localized both post- and presynaptically and are believed to have a pronounced autoreceptor role. The functional importance of these receptors in the regulation of acetylcholine release in the hippocampus and in cognitive processes was ...
Tzavara, E.T., Bymaster, F.P., Felder, C.C., Wade, M., Gomeza Perez, Jesus Elias, Wess, J., McKinzie, D.L., Nomikos, G.G.   +7 more
openaire   +2 more sources

Identification and Role of Muscarinic Receptor Subtypes Expressed in Rat Adrenal Medullary Cells

Journal of Pharmacological Sciences, 2011
.: The muscarinic receptor is known to be involved in the acetylcholine (ACh)-induced secretion of catecholamines in the adrenal medullary (AM) cells of various mammals.
Keita Harada, Hidetada Matsuoka, Takeyoshi Sata, Akira Warashina, Masumi Inoue   +4 more
doaj   +1 more source

Postural Orthostatic Tachycardia Syndrome Is Associated With Elevated G‐Protein Coupled Receptor Autoantibodies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The etiology of postural orthostatic tachycardia syndrome (POTS) is yet to be established. The disorder is often misdiagnosed as chronic anxiety or a panic disorder because the autonomic failure in these patients is not severe.
William T. Gunning, Heather Kvale, Paula M. Kramer, Beverly L. Karabin, Blair P. Grubb   +4 more
doaj   +1 more source

Involvement of Cyclin Dependent Kinase 5 in M4 Muscarinic Acetylcholine Receptor-Mediated Cholinergic Transmission within the Mouse Dorsal Striatum

, 2021
Background: An imbalance between dopamine (DA) and acetylcholine (ACh) within the striatum has reemerged as key to the pathophysiology of the neurodegenerative disorder, Parkinson's disease (PD). M4 is a prominent muscarinic ACh receptor subtype in the
Huijuan Zhou, Hua-xiang Shi, Xing Li, Jingxin Zhang, Xin Sui, Zhe Zhao, Zhiyong Nie, Yongan Wang, J. Li, Liyun Wang   +9 more
semanticscholar   +1 more source