Results 61 to 70 of about 18,462 (237)

Dopamine Signaling in Dorsal Versus Ventral Striatum: The Dynamic Role of Cholinergic Interneurons [PDF]

, 2011
Mesostriatal dopaminergic neurons and striatal cholinergic interneurons participate in signaling the motivational signifcance of environmental stimuli and regulate striatal plasticity. Dopamine (DA) and acetylcholine (ACh) have potent interactions within
Sarah Threlfell, Stephanie Jane Cragg
core   +3 more sources

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +1 more source

Carbachol and bradykinin elevate cyclic AMP and rapidly deplete ATP in cultured rat sympathetic neurons [PDF]

, 1991
The agonists carbachol (CCh) and bradykinin (BK) and 54 mM KCl (high K+) were among the most potent stimulants of cyclic AMP (cAMP) production in cultured rat sympathetic neurons, measured with the use of a high-fidelity assay developed for small samples.
Murrell, R D, Suidan, H S, Tolkovsky, A M   +2 more
core   +3 more sources

Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy

, 2020
Non-selective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson disease and dystonia.
M. Moehle, Aaron M. Bender, J. Dickerson, Daniel J. Foster, Yuping Donsante, Weimin Peng, Zoey Bryant, T. Bridges, Sichen Chang, Katherine J. Watson, Jordan C. O’Neill, Julie L. Engers, Li Peng, Alice L. Rodriguez, C. Niswender, C. Lindsley, E. Hess, P. Conn, J. M. Rook   +18 more
semanticscholar   +1 more source

Modulation of c-Jun NH2-Terminal (JNK) by Cholinergic Autoantibodies from Patients with Sjögren’s Syndrome [PDF]

, 2011
Background: We wanted to determine (via an immunopharmacological approach) whether the c-Jun NH2 terminal kinase (JNK) cascade is phosphorylated in the submandibular gland by carbachol and cholinergic autoantibodies (IgG) present in the sera of patients ...
Borda, Enri Santiago, Passafaro, Daniela, Reina, Silvia, Sterin Borda, Leonor   +3 more
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Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

Frontiers in Molecular Neuroscience, 2018
The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive.
Anna M. Klawonn, Anna M. Klawonn, Daniel B. Wilhelms, Daniel B. Wilhelms, Sarah H. Lindström, Anand Kumar Singh, Anand Kumar Singh, Maarit Jaarola, Jürgen Wess, Michael Fritz, Michael Fritz, David Engblom   +11 more
doaj   +1 more source

M1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior

Pharmacology Research & Perspectives, 2022
Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate alcohol consumption and seeking. Both M4 and M5 mAChRs have been highlighted as potential novel treatment targets for alcohol use disorders (AUD).
Leigh C. Walker, Erin J. Campbell, Kate L. Huckstep, Nicola A. Chen, Christopher J. Langmead, Andrew J. Lawrence   +5 more
doaj   +1 more source

Muscarinic M2 acetylcholine receptor distribution in the guinea-pig gastrointestinal tract [PDF]

, 2006
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells.
58998, 58999, IINO, Satoshi, NOJYO, Yoshiaki   +3 more
core   +1 more source

Insulin Oversecretion in MSG-Obese Rats is Related to Alterations in Cholinergic Muscarinic Receptor Subtypes in Pancreatic Islets

Cellular Physiology and Biochemistry, 2014
Background/ Aims: Impaired pancreatic beta cell function and insulin secretion/action are a link between obesity and type 2 diabetes, which are worldwide public health burdens.
Rosiane A. Miranda, Aryane R. Agostinho, Isis H. Trevenzoli, Luiz F. Barella, Claudinéia C. S. Franco, Amanda B. Trombini, Ananda Malta, Clarice Gravena, Rosana Torrezan, Paulo C. F. Mathias, Júlio C. de Oliveira   +10 more
doaj   +1 more source

Cholinergic regulation of mood: from basic and clinical studies to emerging therapeutics. [PDF]

, 2019
Mood disorders are highly prevalent and are the leading cause of disability worldwide. The neurobiological mechanisms underlying depression remain poorly understood, although theories regarding dysfunction within various neurotransmitter systems have ...
Dulawa, Stephanie C, Janowsky, David S
core