Results 71 to 80 of about 18,227 (256)

Differential regulation of cAMP-mediated gene transcription by m1 and m4 muscarinic acetylcholine receptors. Preferential coupling of m4 receptors to Gi alpha-2

Journal of Biological Chemistry, 1994
We have used a luciferase reporter gene under the transcriptional control of a cAMP response element as a sensitive monitor of the regulation by muscarinic acetylcholine receptors (mAChRs) of intracellular cAMP levels and cAMP-regulated gene expression. Treatment with the muscarinic agonist carbachol results in an increase in luciferase activity in JEG-
Jacques Migeon, Neil M. Nathanson
openalex   +4 more sources

FUNCTIONAL AND PHARMACOLOGICAL CHARACTERIZATION OF A NOVEL AND SELECTIVE MUSCARINIC ACETYLCHOLINE M4 RECEPTOR ACTIVATOR [PDF]

Alzheimer's & Dementia, 2017
Michael Popiolek, Patrick L. Tierney, Damon Young, Susan M. Lotarski, Rouba Kozak   +4 more
openalex   +3 more sources

Muscarinic acetylcholine receptor M1 and M3 subtypes mediate acetylcholine-induced endothelium-independent vasodilatation in rat mesenteric arteries

Journal of Pharmacological Sciences, 2016
The present study investigated pharmacological characterizations of muscarinic acetylcholine receptor (AChR) subtypes involving ACh-induced endothelium-independent vasodilatation in rat mesenteric arteries.
Panot Tangsucharit, Shingo Takatori, Yoshito Zamami, Mitsuhiro Goda, Poungrat Pakdeechote, Hiromu Kawasaki, Fusako Takayama   +6 more
doaj   +1 more source

Generation of Choline for Acetylcholine Synthesis by Phospholipase D Isoforms [PDF]

, 2001
DEDICATION: This article is dedicated to the memory of Sue Kim Hanson, a graduate student in the department of Pathology and Laboratory Medicine at Boston University School of Medicine, who perished in the terrorist attacks of September 11, 2001 ...
Blusztajn, Jan Krzysztof, Frohman, Michael A, Zhao, Di   +2 more
core   +3 more sources

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus [PDF]

, 2015
Muscarinic M1 acetylcholine receptors (M1Rs) are highly expressed in the hippocampus, and their inhibition or ablation disrupts the encoding of spatial memory.
Broad, Lisa M, Colvin, Ellen M, Dennis, Siobhan, Felder, Christian C, Fitzjohn, Steve, Isaac, John T R, Mellor, Jack, Mogg, Adrian J, Pasqui, Francesca, Sanger, Helen   +9 more
core   +1 more source

Discovery of the first selective M4 muscarinic acetylcholine receptor antagonists with in vivo anti-parkinsonian and anti-dystonic efficacy

, 2020
Non-selective antagonists of muscarinic acetylcholine receptors (mAChRs) that broadly inhibit all five mAChR subtypes provide an efficacious treatment for some movement disorders, including Parkinson disease and dystonia.
M. Moehle, Aaron M. Bender, J. Dickerson, Daniel J. Foster, Yuping Donsante, Weimin Peng, Zoey Bryant, T. Bridges, Sichen Chang, Katherine J. Watson, Jordan C. O’Neill, Julie L. Engers, Li Peng, Alice L. Rodriguez, C. Niswender, C. Lindsley, E. Hess, P. Conn, J. M. Rook   +18 more
semanticscholar   +1 more source

Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity

Frontiers in Molecular Neuroscience, 2018
The neurotransmitter acetylcholine has been implicated in reward learning and drug addiction. However, the roles of the various cholinergic receptor subtypes on different neuron populations remain elusive.
Anna M. Klawonn, Anna M. Klawonn, Daniel B. Wilhelms, Daniel B. Wilhelms, Sarah H. Lindström, Anand Kumar Singh, Anand Kumar Singh, Maarit Jaarola, Jürgen Wess, Michael Fritz, Michael Fritz, David Engblom   +11 more
doaj   +1 more source

M1 muscarinic receptor activation decreases alcohol consumption via a reduction in consummatory behavior

Pharmacology Research & Perspectives, 2022
Muscarinic acetylcholine receptors (mAChRs) have been shown to mediate alcohol consumption and seeking. Both M4 and M5 mAChRs have been highlighted as potential novel treatment targets for alcohol use disorders (AUD).
Leigh C. Walker, Erin J. Campbell, Kate L. Huckstep, Nicola A. Chen, Christopher J. Langmead, Andrew J. Lawrence   +5 more
doaj   +1 more source

Evidence for Respiratory Neuromodulator Interdependence after Cholinergic Disruption in the Ventral Respiratory Column [PDF]

, 2015
Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50 mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP),
Forster, Hubert, Hodges, Matthew, Miller, Justin Robert, Muere, Clarissa, Neumueller, Suzanne, Olesiak, Samantha, Pan, Lawrence   +6 more
core   +2 more sources

The Muscarinic Acetylcholine Receptor Agonist BuTAC Mediates Antipsychotic-Like Effects via the M4 Subtype [PDF]

Neuropsychopharmacology, 2013
The generation of muscarinic acetylcholine receptor (mAChR) subtype-selective compounds has been challenging, requiring use of nonpharmacological approaches, such as genetically engineered animals, to deepen our understanding of the potential that members of the muscarinic receptor subtype family hold as therapeutic drug targets.
David B. Shaw, David L. McKinzie, Amy K. Chesterfield, Linda M. Rorick-Kehn, Marla L. Watt, Christian C. Felder, Karen M. Knitowski, Anne T. Quets   +7 more
openaire   +3 more sources