Results 141 to 150 of about 19,182 (246)

P2‐207: Discovery of a highly M5‐preferring muscarinic acetylcholine receptor allosteric potentiator [PDF]

Alzheimer's & Dementia, 2009
P. Jeffrey Conn, Joy E. Marlo, Patrick R. Gentry, C. David Weaver, Thomas M. Bridges, Colleen M. Niswender, Craig W. Lindsley   +6 more
openaire   +2 more sources

Predicting Novel Functional Roles of Designed Small Biomolecules: An ML Approach Utilizing PubChem Compound and Substance Identifiers (CID-SID ML model) [PDF]

arXiv
Significance and Object: The proposed methodology aims to provide time- and cost-effective approach for the early stage in drug discovery. The machine learning models developed in this study used only the identification numbers provided by PubChem.
arxiv  

D-pinitol modulates the anti-emetic effects of aprepitant, domperidone, and ondansetron in chicks

Pharmaceutical Science Advances
Naturally occurring substance, D-pinitol (DPL) belongs to the significant inositol family has numerous pharmacological activity. In this study we evaluated the anti-emetic effect as well as modulation activities of DPL on the recent market drugs ...
Md. Elit Rahman, Md. Anisur Rahman, Salehin Sheikh, Md. Jannatul Islam Polash, Sozoni Khatun, Mst. Sonia Akter Bristi, Md. Showkoth Akbor, Mst. Farjanamul Haque, Mehedi Hasan Bappi, Tohidul Islam Tanim, Siddique Akber Ansari, Irfan Aamer Ansari, Elaine Cristina Pereira Lucetti, Carolina Bandeira Domiciano, Henrique D.M. Coutinho, Muhammad Torequl Islam   +15 more
doaj  

Vagus nerve stimulation as a modulator of feedforward and feedback neural transmission [PDF]

arXiv
Vagus nerve stimulation (VNS) has emerged as a promising therapeutic intervention across various neurological and psychiatric conditions, including epilepsy, depression, and stroke rehabilitation; however, its mechanisms of action on neural circuits remain incompletely understood.
arxiv  

CreoPep: A Universal Deep Learning Framework for Target-Specific Peptide Design and Optimization [PDF]

arXiv
Target-specific peptides, such as conotoxins, exhibit exceptional binding affinity and selectivity toward ion channels and receptors. However, their therapeutic potential remains underutilized due to the limited diversity of natural variants and the labor-intensive nature of traditional optimization strategies. Here, we present CreoPep, a deep learning-
arxiv  

Discovery, Synthesis and Characterization of a Highly Muscarinic Acetylcholine Receptor (mAChR)‐Selective M5‐Orthosteric Antagonist, VU0488130 (ML381): A Novel Molecular Probe

ChemMedChem, 2014
P. Gentry, M. Kokubo, T. Bridges, Hyekyung P. Cho, Emery Smith, Peter S. Chase, P. Hodder, T. Utley, A. Rajapakse, Frank W. Byers, C. Niswender, R. Morrison, J. Daniels, M. Wood, P. Conn, C. Lindsley   +15 more
semanticscholar   +1 more source

Editorial: Mechanisms of cholinergic transmission in motivation and cognition. [PDF]

Front Mol Neurosci
Francis TC, Klawonn AM.
europepmc   +1 more source

Modulation of lower urinary tract smooth muscle contraction and relaxation by the urothelium [PDF]

, 2018
Chess-Williams, Russ, Michel, Martin C., Sellers, Donna   +2 more
core   +1 more source

Acetylcholine in the hippocampus: problems and achievements. [PDF]

Front Neural Circuits
Dobryakova YV, Bolshakov AP, Korotkova T, Rozov AV.   +3 more
europepmc   +1 more source

The mechanism of action of clozapine. [PDF]

J Psychopharmacol
Morrison PD, Jauhar S, Young AH.
europepmc   +1 more source