Results 161 to 170 of about 5,023 (210)
Life Sciences, 1993 Knowledge of the distributions and functions of native m1-m5 muscarinic acetylcholine receptors in tissues is limited. To characterize the family of m1-m5 proteins directly, a panel of subtype-selective antibodies was generated against divergent i3 loop-fusion proteins. Each antibody was shown to bind a single cloned receptor specifically.
Allan I. Levey
+5 more sources
Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes
Neuron, 1988 The human and rat genes for a fifth muscarinic receptor have been cloned and expressed in mammalian cells. The 532 amino acid human protein has 89% sequence identity to the 531 amino acid rat protein and is most closely related to the m3 receptor. Both proteins are encoded by single exons.
Tom I. Bonner +3 more
openalex +4 more sources
Life Sciences, 2003 Until recently, little was known about the possible physiological functions of the M(5) muscarinic acetylcholine receptor subtype, the last member of the muscarinic receptor family (M(1)-M(5)) to be cloned. To learn more about the potential physiological roles of this receptor subtype, we generated and analyzed M(5) receptor-deficient mice (M5 -/- mice)
Masahisa Yamada +9 more
openalex +4 more sources
Human skin fibroblasts express m2, m4, and m5 subtypes of muscarinic acetylcholine receptors
Journal of Cellular Biochemistry, 1999 Previous studies have demonstrated that muscarinic acetylcholine receptors (mAChRs) are expressed by human skin fibroblasts (HSF). We have identified the molecular subtypes of these receptors by reverse transcription-polymerase chain reaction (RT-PCR), using m1-m5 subtype-specific primers.
Rico Buchli +5 more
+6 more sources
Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase.
The Journal of Pharmacology and Experimental Therapeutics, 1994 The coupling of m5 muscarinic acetylcholine receptors to the generation and release of nitric oxide (NO) was investigated. Chinese hamster ovary cells, which stably express m5 receptors, were transiently transfected with the gene encoding neuronal NO synthase and used as a model system. Increased generation of NO upon stimulation of cells by muscarinic
Shou Zhen Wang +2 more
openalex +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
The Journal of Pharmacology and Experimental Therapeutics, 2023
The type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area and substantia nigra pars compacta; therefore, they are ideally located to modulate DA signaling and underlying behaviors. However, the role of M5 in shaping DA release is still poorly characterized.
Vivien Zell +12 more
openaire +2 more sources
The type-5 muscarinic acetylcholine receptor (mAChR, M5) is almost exclusively expressed in dopamine (DA) neurons of the ventral tegmental area and substantia nigra pars compacta; therefore, they are ideally located to modulate DA signaling and underlying behaviors. However, the role of M5 in shaping DA release is still poorly characterized.
Vivien Zell +12 more
openaire +2 more sources
An Improved Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor
Synfacts, 2022 Dirk Trauner, Christopher J. Arp
openalex +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010 Besides some pharmacological, biochemical and biophysical evidences support the contention that muscarinic acetylcholine receptors can form homo- and heterodimers, the existence of specific M3 and M5 muscarinic receptors oligomers in living cells is a new concept.
Dasiel O. Borroto‐Escuela +4 more
openalex +6 more sources