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Considerations for Augmenting Aripiprazole Long-Acting Injectables with Other Antipsychotics: A Mini-Review. [PDF]
DiseasesShaw J +5 more
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Azaspirooctane-carboxylates as Novel Activators/Modulators of M4 for the Treatment of Alzheimer's Disease and Parkinson's Disease. [PDF]
ACS Med Chem LettRosse G.
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Antipsychotic drugs at 75: the past, present, and future of psychosis management. [PDF]
Br Med BullLyman M, McCutcheon RA.
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The neural niche in cancer: mechanistic insights into tumor-neuron-immune crosstalk and therapeutic opportunities. [PDF]
Front Cell Dev BiolAysit N +4 more
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Muscarinic Acetylcholine Receptor M5
Definitions, 2020Muscarinic acetylcholine receptor M5 (532 aa, ~60 kDa) is encoded by the human CHRM5 gene. This protein plays a role in both acetylcholine binding and G protein-coupled receptor signaling.
semanticscholar +2 more sources
The Muscarinic Acetylcholine Receptor M5: Therapeutic Implications and Allosteric Modulation.
ACS Chemical Neuroscience, 2018The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications.
Aaron M. Bender +2 more
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Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.
Neuron, 1988The human and rat genes for a fifth muscarinic receptor have been cloned and expressed in mammalian cells. The 532 amino acid human protein has 89% sequence identity to the 531 amino acid rat protein and is most closely related to the m3 receptor. Both proteins are encoded by single exons.
T. Bonner +3 more
semanticscholar +3 more sources
Activation mechanism of the M5 muscarinic acetylcholine receptor.
Biophysical Journal, 2023L. Roy +3 more
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