Results 171 to 180 of about 5,170 (209)

Estrogen prevents cerebrovascular deficits by the lack of M5 muscarinic acetylcholine receptor through MAPK activation

Neuroscience Research, 2007
Runa Araya, Naohito Kitamura, Tetsuya Kimura, Jürgen Wess, Masahisa Yamada   +4 more
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Pharmacology of muscarinic acetylcholine receptor subtypes (m1–m5): high throughput assays in mammalian cells

European Journal of Pharmacology, 1996
Based on the ability of many receptors to amplify NIH 3T3 cells, we developed a high throughput assay of cloned receptor pharmacology. In this assay, receptors are transiently co-expressed with the marker enzyme beta-galactosidase. Receptors that induce cellular proliferation select and amplify the cells that also express the marker, thus the ability ...
Hans Bräuner‐Osborne, Mark R. Brann
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Microscopic Binding of M5 Muscarinic Acetylcholine Receptor with Antagonists by Homology Modeling, Molecular Docking, and Molecular Dynamics Simulation [PDF]

The Journal of Physical Chemistry B, 2011
By performing homology modeling, molecular docking, and molecular dynamics (MD) simulations, we have developed three-dimensional (3D) structural models of the M5 muscarinic acetylcholine receptor (mAChR) and two complexes for M5 mAChR binding with antagonists SVT-40776 and solifenacin in the environment of lipid bilayer and solvent water.
Xiaoqin Huang, Guangrong Zheng, Chang‐Guo Zhan   +2 more
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Role for M₅ muscarinic acetylcholine receptors in cocaine addiction

Journal of Neuroscience Research, 2003
AbstractMuscarinic cholinergic receptors of the M5 subtype are expressed by dopamine‐containing neurons of the ventral tegmentum. These M5 receptors modulate the activity of midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties of abused psychostimulants like cocaine.
Fink-Jensen, A., Fedorova, I., Wörtwein, Gitta, Woldbye, David P. D., Rasmussen, T., Thomsen, M., Bolwig, Tom G., Knitowski, K.M., McKinzie, D.L., Yamada, M., Wess, J., Basile, A.   +11 more
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Discovery of M5 Muscarinic Acetylcholine Receptor Antagonists: 1‐Methyl‐4‐Phenylpiperidine Analogs

The FASEB Journal, 2015
Na‐Ra Lee, Xuan Zhang, Mahesh Darna, Guangrong Zheng, Linda P. Dwoskin   +4 more
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Muscarinic—but Not Nicotinic—Acetylcholine Receptors Mediate a Nitric Oxide-Dependent Dilation in Brain Cortical Arterioles: A Possible Role for the M5 Receptor Subtype [PDF]

Journal of Cerebral Blood Flow & Metabolism, 2000
Increases in cortical cerebral blood flow are induced by stimulation of basal forebrain cholinergic neurons. This response is mediated in part by nitric oxide (NO) and reportedly involves both nicotinic and muscarinic receptors, some of which are possibly located in the vessel wall.
Ahmed Elhusseiny, Édith Hamel
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Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice

Journal of Neuroimmunology, 2007
Immunological activation of T cells enhances synthesis of acetylcholine (ACh) and transcription of choline acetyltransferase (ChAT), M5 muscarinic ACh receptor (mAChR) and acetylcholinesterase (AChE). Stimulation of mAChRs on T and B cells causes oscillating Ca(2+)-signaling and up-regulation of c-fos expression; moreover, M1 mAChRs play a crucial role
Yoshihito X. Fujii, Ayako Tashiro, Kumiko Arimoto, Hirofumi Fujigaya, Yasuhiro Moriwaki, Hidemi Misawa, Takeshi Fujii, Minoru Matsui, Tadashi Kasahara, Koichiro Kawashima   +9 more
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The Muscarinic Acetylcholine Receptor M ₅ : Therapeutic Implications and Allosteric Modulation

ACS Chemical Neuroscience, 2018
The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications. Early studies with knockout animals have provided clues to the receptor's role in physiological processes related to Alzheimer's disease, schizophrenia, and addiction ...
Aaron M. Bender, Aaron T. Garrison, Craig W. Lindsley   +2 more
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Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1995
The neuromuscular blocking drug alcuronium was found earlier to increase the affinity of muscarinic receptors for methyl-N-scopolamine (NMS). This effect could be observed in some but not in other tissues. Subtype selectivity of the positive allosteric action of alcuronium was now investigated in radioligand binding experiments in Chinese hamster ovary
Ján Jakubík, Lucie Bačáková, Esam E. El‐Fakahany, S Tucek   +3 more
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Isolation and Functional Characterization of the Chick M₅ Muscarinic Acetylcholine Receptor Gene

Journal of Neurochemistry, 2000
Abstract: The chick is a widely used system for study of the actions of muscarinic acetylcholine receptors in the cardiovascular, visual, and nervous systems. We report the isolation and functional analysis of the gene encoding the chick M5 muscarinic receptor.
S, Creason, K M, Tietje, N M, Nathanson
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