Results 181 to 190 of about 5,023 (210)

Pharmacology of muscarinic acetylcholine receptor subtypes (m1–m5): high throughput assays in mammalian cells

European Journal of Pharmacology, 1996
Based on the ability of many receptors to amplify NIH 3T3 cells, we developed a high throughput assay of cloned receptor pharmacology. In this assay, receptors are transiently co-expressed with the marker enzyme beta-galactosidase. Receptors that induce cellular proliferation select and amplify the cells that also express the marker, thus the ability ...
Hans Bräuner‐Osborne, Mark R. Brann
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The Muscarinic Acetylcholine Receptor M₅: Therapeutic Implications and Allosteric Modulation

ACS Chemical Neuroscience, 2018
The muscarinic acetylcholine receptor (mAChR) subtype 5 (M5) was the most recent mAChR to be cloned and has since emerged as a potential therapeutic target for a number of indications. Early studies with knockout animals have provided clues to the receptor's role in physiological processes related to Alzheimer's disease, schizophrenia, and addiction ...
Craig W. Lindsley, Craig W. Lindsley, Aaron T. Garrison, Aaron T. Garrison, Aaron M. Bender, Aaron M. Bender   +5 more
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Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.

The Journal of Pharmacology and Experimental Therapeutics, 1995
The neuromuscular blocking drug alcuronium was found earlier to increase the affinity of muscarinic receptors for methyl-N-scopolamine (NMS). This effect could be observed in some but not in other tissues. Subtype selectivity of the positive allosteric action of alcuronium was now investigated in radioligand binding experiments in Chinese hamster ovary
Ján Jakubík, Lucie Bačáková, Esam E. El‐Fakahany, S Tucek   +3 more
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Muscarinic M5 receptors trigger acetylcholine‐induced Ca²⁺ signals and nitric oxide release in human brain microvascular endothelial cells

Journal of Cellular Physiology, 2018
AbstractBasal forebrain neurons control cerebral blood flow (CBF) by releasing acetylcholine (Ach), which binds to endothelial muscarinic receptors to induce nitric (NO) release and vasodilation in intraparenchymal arterioles. Nevertheless, the mechanism whereby Ach stimulates human brain microvascular endothelial cells to produce NO is still unknown ...
Estella Zuccolo, Umberto Laforenza, Sharon Negri, Laura Botta, Roberto Berra‐Romani, Pawan Faris, Giorgia Scarpellino, Greta Forcaia, Giorgia Pellavio, Giulio Sancini, Francesco Moccia   +10 more
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Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice

Journal of Neuroimmunology, 2007
Immunological activation of T cells enhances synthesis of acetylcholine (ACh) and transcription of choline acetyltransferase (ChAT), M5 muscarinic ACh receptor (mAChR) and acetylcholinesterase (AChE). Stimulation of mAChRs on T and B cells causes oscillating Ca(2+)-signaling and up-regulation of c-fos expression; moreover, M1 mAChRs play a crucial role
Yoshihito X. Fujii, Ayako Tashiro, Kumiko Arimoto, Hirofumi Fujigaya, Yasuhiro Moriwaki, Hidemi Misawa, Takeshi Fujii, Minoru Matsui, Tadashi Kasahara, Koichiro Kawashima   +9 more
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Cloning of the rat m3, m4 and m5 muscarinic acetylcholine receptor genes by the Polymerase Chain Reaction (PCR) and the pharmacological characterization of the expressed genes

Life Sciences, 1992
The coding sequence of the rat m3, m4 and m5 subtypes of muscarinic acetylcholine receptor (mAChR) genes was amplified by the polymerase chain reaction (PCR), cloned, and expressed in the murine fibroblast (B82) cell line. Sequencing of the cloned genes revealed some nucleotide differences when compared with the DNA sequence published in the literature.
Kenichi Kashihara, Éva Varga, Sue Waite, William R. Roeske, Henry I. Yamamura   +4 more
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Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
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Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-vornhagen, Victoria Metaxa, Elie Azoulay   +2 more
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul H Parikh
exaly  

Current treatment and recent progress in gastric cancer

Ca-A Cancer Journal for Clinicians, 2021
Smita S Joshi, Brian D Badgwell
exaly