Results 191 to 200 of about 20,015 (223)

Discovery and structure-activity relationships study of positive allosteric modulators of the M3 muscarinic acetylcholine receptor.

Bioorganic & Medicinal Chemistry, 2020
The M3 muscarinic acetylcholine receptor (mAChR) is a member of the family of mAChRs, which are associated with a variety of physiological functions including the contraction of various smooth muscle tissues, stimulation of glandular secretion, and ...
Hiroaki Tanaka, K. Negoro, Takanori Koike, Issei Tsukamoto, K. Yokoyama, Jun Maeda, Yusuke Inagaki, Yukinori Shimoshige, Katsutoshi Ino, Kenichiro Ishizu, Taisuke Takahashi   +10 more
semanticscholar   +1 more source

A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor

2010
A thesis presented to the faculty of The Rockefeller University in partial fulfillment of the requirements for the degree of Doctor of ...
openaire   +1 more source

Upregulation of mRNA Encoding the M5 Muscarinic Acetylcholine Receptor in Human T- and B-Lymphocytes During Immunological Responses

Neurochemical Research, 2003
Lymphocytes possess an independent, non-neuronal cholinergic system. Moreover, both T- and B-lymphocytes express multiple muscarinic acetylcholine receptors (mAChR). To obtain a better understanding of the regulatory mechanisms governing mAChR gene expression in the lymphocytic cholinergic system, we examined the effects of lymphocyte activation on ...
Takeshi, Fujii, Yoshihiro, Watanabe, Tomoyuki, Inoue, Koichiro, Kawashima   +3 more
openaire   +2 more sources

Muscarinic M5 receptors trigger acetylcholine‐induced Ca²⁺ signals and nitric oxide release in human brain microvascular endothelial cells

Journal of Cellular Physiology, 2018
AbstractBasal forebrain neurons control cerebral blood flow (CBF) by releasing acetylcholine (Ach), which binds to endothelial muscarinic receptors to induce nitric (NO) release and vasodilation in intraparenchymal arterioles. Nevertheless, the mechanism whereby Ach stimulates human brain microvascular endothelial cells to produce NO is still unknown ...
Zuccolo, Estella, Laforenza, Umberto, Negri, Sharon, Botta, Laura, Berra-Romani, Roberto, Faris, Pawan, Scarpellino, Giorgia, Forcaia, Greta, Pellavio, Giorgia, Sancini, Giulio, Moccia, Francesco   +10 more
openaire   +4 more sources

Design and Synthesis of Dualsteric Muscarinic M5 Receptor Ligands Reveal G Protein Bias.

ACS Chemical Neuroscience
The M5 muscarinic acetylcholine receptor (M5R) is selectively expressed in dopaminergic neurons where it plays a key role in modulating dopaminergic activity, making it a promising target for neuropsychiatric disorders.
S. A. M. Steinmüller, Alix C Flake, Marcel Bermúdez, P. Ashdown, J. Hislop, Michael Decker   +5 more
semanticscholar   +1 more source

Kinetic assays to characterize fluorescent ligand binding to muscarinic acetylcholine M1 receptor.

Biochemical Pharmacology
Muscarinic acetylcholine receptors (M1-M5), which belong to the superfamily of G protein-coupled receptors (GPCRs), play a crucial role in regulating essential physiological processes and serve as significant targets in pharmaceutical research.
Tõnis Laasfeld, Hana Bláhovcová, Kaspar Hollo, S. Veiksina, A. Rinken, Anni Allikalt   +5 more
semanticscholar   +1 more source

Diminished antigen-specific IgG1 and interleukin-6 production and acetylcholinesterase expression in combined M1 and M5 muscarinic acetylcholine receptor knockout mice

Journal of Neuroimmunology, 2007
Immunological activation of T cells enhances synthesis of acetylcholine (ACh) and transcription of choline acetyltransferase (ChAT), M5 muscarinic ACh receptor (mAChR) and acetylcholinesterase (AChE). Stimulation of mAChRs on T and B cells causes oscillating Ca(2+)-signaling and up-regulation of c-fos expression; moreover, M1 mAChRs play a crucial role
Yoshihito X, Fujii, Ayako, Tashiro, Kumiko, Arimoto, Hirofumi, Fujigaya, Yasuhiro, Moriwaki, Hidemi, Misawa, Takeshi, Fujii, Minoru, Matsui, Tadashi, Kasahara, Koichiro, Kawashima   +9 more
openaire   +2 more sources

Structure of the M5 muscarinic acetylcholine receptor (M5-T4L) bound to tiotropium

, 2019
Ziva Vuckovic, P. Gentry, Alice E. Berizzi, K. Hirata, Swapna Varghese, Geoff V. Thompson, E. Westhuizen, Wessel A. C. Burger, Raphaël Rahmani, C. Valant, C. Langmead, C. Lindsley, J. Baell, A. Tobin, P. Sexton, A. Christopoulos, D. Thal   +16 more
semanticscholar   +1 more source

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Chimeric antigen receptor T‐cell therapy in multiple myeloma: A comprehensive review of current data and implications for clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Rujul Parikh
exaly