Results 191 to 200 of about 26,727 (247)
Dioxane and oxathiane nuclei: Suitable substructures for muscarinic agonists
Bioorganic and Medicinal Chemistry, 2007 Muscarinic agonists, bearing 1,4-dioxane and 1,4-oxathiane nuclei, were synthesized and tested to evaluate their potency at M(1)-M(4) muscarinic receptor subtypes. The stereochemical relationship between the 2-side chain and the 6-methyl group plays an important role in drug-receptor interaction, since the cis isomers are more potent than the ...
Alessandro Piergentili +2 more
exaly +8 more sources
New functionally selective muscarinic agonists
Life Sciences, 1993 The muscarinic pharmacology of two novel agonists related to McN-A-343, 4-F-PyMcN and 4-F-PyMcN+, has been studied by the use of pharmacological and radioligand binding techniques. Both compounds were potent agonists at M1 receptors in rabbit vas deferens (pEC50 = 6.24 and 6.96) and rat duodenum (pEC50 = 5.47 and 6.38), but very weak partial agonists ...
Lambrecht, Günter +8 more
openaire +4 more sources
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Muscarinic agonists in Alzheimer's disease
Life Sciences, 1997As therapeutic agents, M1 agonists in the short-term may palliate symptoms of AD and improve memory function. In the long-term, M1 agonists have the potential to modify the underlying pathophysiology of AD, and thereby prevent or retard the course of dementia.
John H Growdon, J H Growdon
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Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens
European Journal of Pharmacology, 1993In the electrically field-stimulated rabbit vas deferens, muscarinic receptor agonists increase twitch-height by actions at postjunctional M2 receptors and decrease twitch-height by actions at prejunctional M1 receptors. In the present studies, in contrast to previous reports, muscarinic receptor agonists primarily decreased twitch-height, produced ...
Harlan E Shannon +2 more
exaly +3 more sources
Use of Muscarinic Agonists in the Treatment of Sjögren's Syndrome
Clinical Immunology, 2001Two muscarinic agonists (pilocarpine and cevimeline) have recently been approved for the treatment of symptoms of xerostomia in Sjögren's syndrome (SS). These agents stimulate the M1 and M3 receptors present on salivary glands, leading to increased secretory function. The use of these agents emphasizes the importance of neuroendocrine mechanisms in SS,
Robert I Fox, Abraham Fisher
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Muscarinic Agonists and Antagonists: Effects on the Urinary Bladder
, 2011 Voiding of the bladder is the result of a parasympathetic muscarinic receptor activation of the detrusor smooth muscle. However, the maintenance of continence and a normal bladder micturition cycle involves a complex interaction of cholinergic, adrenergic, nitrergic and peptidergic systems that is currently little understood.
Sellers, Donna J., Chess-Williams, Russ
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British Journal of Pharmacology, 2006 1 In airway smooth muscle (ASM), full and partial muscarinic receptor agonists have been described to have large differences in their ability to induce signal transduction, including Ca2+-mobilization.
Dedmer Schaafsma +2 more
exaly +2 more sources
Muscarinic agonist SAR of azaspirodioxolanes
Bioorganic & Medicinal Chemistry Letters, 1992The in vitro muscarinic activity and a model for binding to the m1 receptor are presented for a series of azaspirodioxolanes.
SHAPIRO, G +9 more
openaire +2 more sources