Results 211 to 220 of about 26,727 (247)
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Muscarinic Agonists as Insecticides and Acaricides
Pesticide Science, 1997A series of known agonists of the mammalian muscarinic receptor were prepared and evaluated for their insecticidal potential. It was discovered that pests such as Nilaparvata lugens (brown planthopper), Nephotettix cincticeps (green leafhopper), Tetranychus urticae (two-spotted spider mite) and Aphis gossypii (cotton aphid) were particularly sensitive ...
Michael R. Dick +2 more
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Blockade of muscarinic receptors by alkylating agonist analogues
Biochemical Society Transactions, 1990F. ( 1987) J. Nrirrochrm. 48. 154159 4. Perry, E. K., Perry, R. H. & Tomlinson, B. E. (1982) Neurosci. Lett. 29,303-307 5. Hohorst, H.-J. ( 1965) in Methods of Etizymcitic Anulysis (Bergmeyer H.-U., ed.). pp. 266-270, Academic Press, New York 6. Hardy, J. A,, Wester, P.. Winblad. B.. Gezelius, C.. Bring. G . & Eriksson, A. ( 1985) J. Neitrul7rutism. 61,
E C, Hulme +4 more
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Muscarinic agonists provide a new class of acaricide
Nature, 1976THE resistance of ticks to chemical methods of control is an increasingly serious problem1–5, and new classes of compounds with high acaricidal activity and low mammalian toxicity are needed urgently. In the search for novel acaricides the nervous system is a prime target, and, in spite of evidence about the role of γ-aminobutyrate and gluta-mate in ...
D C, Bigg, S R, Purvis
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Muscarinic Receptor Subtypes and the Selectivity of Agonists and Antagonists
Pharmacology, 2008Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology.
N J, Birdsall +6 more
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Potential Role of Muscarinic Agonists in Alzheimerʼs Disease
Drugs & Aging, 1997Alzheimer's disease (AD) is a common neurodegenerative disorder and a leading cause of death among the elderly. Recent advances in our understanding of the neurobiology of AD have provided scientific groundwork for the development of potentially more effective and less toxic treatment strategies for the disease.
E E, Avery, L D, Baker, S, Asthana
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Quinuclidinone O-Alkynyloximes with muscarinic agonist activity
Bioorganic & Medicinal Chemistry, 2002A series of quinuclidinone O-alkynyloximes (14-19) were synthesized and evaluated in radioligand displacement assays for binding affinities to M1-M3 muscarinic receptors. Radioligand displacement assays were carried out using [3H] oxotremorine-M and [3H] pirenzepine on rat cortical tissue and [3H] N-methylscopolamine on rat heart and submandibulary ...
Somanadhan, B. +3 more
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The Role of Muscarinic K+ Channels in the Negative Chronotropic Effect of a Muscarinic Agonist
The Journal of Pharmacology and Experimental Therapeutics, 2002Acetylcholine causes bradycardia through M2 muscarinic receptors in sinoatrial node cells. I examined with electrocardiogram how the muscarinic K(+) (K(ACh)) channel participates in the sinus bradycardia induced by a muscarinic agonist in the Langendorff preparation of rabbit hearts.
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Striatal muscarinic receptors: Regulation by dopaminergic agonists
Life Sciences, 1981Abstract The effects of apomorphine on the binding properties of striatal muscarinic receptors were investigated using the specific muscarinic antagonist, [ 3 H](−)3-quinuclidinyl benzilate ([ 3 H](−)QNB). When binding measurements were made in 50 mM sodium/HEPES buffer, pH 7.4, containing Mg +2 , the binding of [ 3 H](−)QNB was consistent with the ...
F J, Ehlert, W R, Roeske, H I, Yamamura
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Characterization of muscarinic agonists in recombinant cell lines
Life Sciences, 1993Using recombinant CHO cells that express Hm1-Hm5 receptors, reference muscarinic agonists have been characterized with respect to their activity in receptor binding and second messenger assays. In whole cell [3H]-N-methyl scopolamine binding, no agonist was found to be truly subtype selective, although some showed marked differences between several of ...
R D, Schwarz +5 more
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CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment
This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...Abraham, Fisher, Allan I, Levey
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