Results 201 to 210 of about 26,727 (247)

Tetramethylammonium is a muscarinic agonist in rat heart

American Journal of Physiology-Cell Physiology, 1995
Studies were designed to determine if tetramethylammonium (TMA), a quaternary amine that structurally resembles the cationic portion of acetylcholine, can affect cardiac function by acting on muscarinic receptors. Experiments examined effects of this cation on 1) the spontaneous beating rate of right atrial preparations isolated from rats, 2) force of
R H, Kennedy, R P, Wyeth, P, Gerner, S, Liu, H J, Fontenot, E, Seifen   +5 more
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Muscarinic Agonists for the Treatment of Cognition in Schizophrenia

CNS Spectrums, 2008
ABSTRACTIt is widely accepted that cholinergic activity at muscarinic receptors is required to maintain cognitive functions, including learning and memory. Memory domains are especially impaired in schizophrenia, which may explain difficulties in psychosocial rehabilitation of individuals with this illness.
Angela K, Sellin, Mujeeb, Shad, Carol, Tamminga   +2 more
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Selective Muscarinic Receptor Agonists and Antagonists

Pharmacology & Toxicology, 1996
Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
R M, Eglen, N, Watson
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Binding of agonists and antagonists to muscarinic receptors

Journal of Supramolecular Structure, 1976
AbstractThe binding of one irreversible and two reversible radioactive antagonists to muscarinic receptors in synaptosome preparations of rat cerebral cortex has been studied. The ligands all bind to the same receptor pool and directly and competitively yield self‐consistent binding constants closely similar to those obtained by pharmacological methods
N J, Birdsall, A S, Burgen, C R, Hiley, E C, Hulme   +3 more
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Discriminative stimulus properties of muscarinic agonists

Psychopharmacology, 1987
In a two-lever, food-reinforced drug-discrimination paradigm separate groups of rats were trained to discriminate either arecoline, pilocarpine or oxotremorine from saline. The discriminative cues of all three agonists were potently blocked by scopolamine, but only by 30-60 fold higher doses of methylscopolamine.
M, Jung, L, Costa, G T, Shearman, P H, Kelly   +3 more
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Cross-tolerance between muscarinic agonists: Role of muscarinic receptors

Pharmacology Biochemistry and Behavior, 1987
In order to explore the relationship between response to muscarinic agonists and brain muscarinic receptors, two mouse strains that differ in acute sensitivity (DBA and C3H) were injected chronically with DFP or infused with oxotremorine. Chronic DFP-treated DBA mice were not tolerant to DFP's effects on any measure, but they were cross-tolerant to the
A C, Collins, T N, Smolen, A, Smolen, L J, Medhurst   +3 more
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Allosteric Modulators and Selective Agonists of Muscarinic Receptors

Journal of Molecular Neuroscience, 2006
Allosteric modulators of ligand-receptor interactions are found for a variety of receptors (Christopoulos, 2002). Allosteric agents attach to a binding site being topographically distinct from the site for conventional (orthosteric) agonists or antagonists.
U. HOLZGRABE, M. DE AMICI, K. MOHR
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Muscarinic receptor agonists and antagonists

Expert Opinion on Therapeutic Patents, 1999
Although four different subtypes of the muscarinic acetylcholine (ACh) receptor with functional correlates are known to exist (function for M5 is still unclear), all muscarinic agonists and antagon...
Darius P Zlotos, Wiebke Bender, Ulrike Holzgrabe   +2 more
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Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors.

European Journal of Pharmacology, 2004
The muscarinic toxin MT7 is the most selective ligand for the muscarinic M(1) receptors. Previous studies have shown that the toxin interacts with the antagonist-receptor complex and slows the antagonist dissociation rate, possibly by binding to an allosteric site and impeding the access to and egress from the orthosteric binding pocket. In the present
OLIANAS, MARIA CONCETTA, ADEM A, KARLSSON E, ONALI, PIER LUIGI   +3 more
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Muscarinic agonists and antagonists in the treatment of Alzheimer's disease

Il Farmaco, 2001
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activity. Although symptoms of AD have been successfully treated with acetylcholinesterase inhibitors
W, Greenlee, J, Clader, T, Asberom, S, McCombie, J, Ford, H, Guzik, J, Kozlowski, S, Li, C, Liu, D, Lowe, S, Vice, H, Zhao, G, Zhou, W, Billard, H, Binch, R, Crosby, R, Duffy, J, Lachowicz, V, Coffin, R, Watkins, V, Ruperto, C, Strader, L, Taylor, K, Cox   +23 more
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