Results 201 to 210 of about 416,055 (267)

Muscarinic Agonists and Antagonists: Effects on Gastrointestinal Function

Handbook of Experimental Pharmacology, 2011
Muscarinic agonists and antagonists are used to treat a handful of gastrointestinal (GI) conditions associated with impaired salivary secretion or altered motility of GI smooth muscle. With regard to exocrine secretion, the major muscarinic receptor expressed in salivary, gastric, and pancreatic glands is the M₃ with a small contribution of the M₁ ...
Ehlert, Frederick J., Pak, K. J., Griffin, Michael T.   +2 more
openaire   +3 more sources

Muscarinic agonists provide a new class of acaricide

Nature, 1976
THE resistance of ticks to chemical methods of control is an increasingly serious problem1–5, and new classes of compounds with high acaricidal activity and low mammalian toxicity are needed urgently. In the search for novel acaricides the nervous system is a prime target, and, in spite of evidence about the role of γ-aminobutyrate and gluta-mate in ...
D C, Bigg, S R, Purvis
openaire   +3 more sources

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.

American Journal of Psychiatry, 2022
Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across the entire spectrum of core symptoms as well as their often burdensome side-effect profiles and poor tolerability.
S. Paul, S. Yohn, M. Popiolek, Andrew C. Miller, C. Felder   +4 more
semanticscholar   +1 more source

Muscarinic agonist SAR of azaspirodioxolanes

Bioorganic & Medicinal Chemistry Letters, 1992
The in vitro muscarinic activity and a model for binding to the m1 receptor are presented for a series of azaspirodioxolanes.
SHAPIRO, G, FLOERSHEIM, P, AMSTUTZ, R, BODDEKE, H, BOLLIGER, G, COTTENS, S, ENZ, A, GMELIN, G, GULL, P, SUPAVILAI, P   +9 more
openaire   +2 more sources

New functionally selective muscarinic agonists

Life Sciences, 1993
The muscarinic pharmacology of two novel agonists related to McN-A-343, 4-F-PyMcN and 4-F-PyMcN+, has been studied by the use of pharmacological and radioligand binding techniques. Both compounds were potent agonists at M1 receptors in rabbit vas deferens (pEC50 = 6.24 and 6.96) and rat duodenum (pEC50 = 5.47 and 6.38), but very weak partial agonists ...
Lambrecht, Günter, Moser, Ursula, Grimm, U, Pfaff, Otmar, Hermanni, Ulrike, Hildebrandt, Caren, Waelbroeck, Magali, Christophe, Jean, Mutschler, Ernst   +8 more
openaire   +2 more sources

Muscarinic M1 receptor agonist actions of muscarinic receptor agonists in rabbit vas deferens

European Journal of Pharmacology, 1993
In the electrically field-stimulated rabbit vas deferens, muscarinic receptor agonists increase twitch-height by actions at postjunctional M2 receptors and decrease twitch-height by actions at prejunctional M1 receptors. In the present studies, in contrast to previous reports, muscarinic receptor agonists primarily decreased twitch-height, produced ...
H E, Shannon, B D, Sawyer, K G, Bemis, F P, Bymaster, I, Health, C H, Mitch, J S, Ward   +6 more
openaire   +2 more sources

Cross-tolerance between muscarinic agonists: Role of muscarinic receptors

Pharmacology Biochemistry and Behavior, 1987
In order to explore the relationship between response to muscarinic agonists and brain muscarinic receptors, two mouse strains that differ in acute sensitivity (DBA and C3H) were injected chronically with DFP or infused with oxotremorine. Chronic DFP-treated DBA mice were not tolerant to DFP's effects on any measure, but they were cross-tolerant to the
A C, Collins, T N, Smolen, A, Smolen, L J, Medhurst   +3 more
openaire   +2 more sources

Selective Muscarinic Receptor Agonists and Antagonists

Pharmacology & Toxicology, 1996
Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
R M, Eglen, N, Watson
openaire   +2 more sources

Discriminative stimulus properties of muscarinic agonists

Psychopharmacology, 1987
In a two-lever, food-reinforced drug-discrimination paradigm separate groups of rats were trained to discriminate either arecoline, pilocarpine or oxotremorine from saline. The discriminative cues of all three agonists were potently blocked by scopolamine, but only by 30-60 fold higher doses of methylscopolamine.
M, Jung, L, Costa, G T, Shearman, P H, Kelly   +3 more
openaire   +2 more sources

Muscarinic receptor agonists and antagonists

Expert Opinion on Therapeutic Patents, 1999
Although four different subtypes of the muscarinic acetylcholine (ACh) receptor with functional correlates are known to exist (function for M5 is still unclear), all muscarinic agonists and antagon...
Darius P Zlotos, Wiebke Bender, Ulrike Holzgrabe   +2 more
openaire   +1 more source