Results 221 to 230 of about 496,043 (271)
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Journal of Pharmacology and Experimental Therapeutics, 1993
Chinese hamster ovary cell lines which stably express individual subtypes of muscarinic acetylcholine receptors (m1-m5) were used to assess the potential selectivity of known muscarinic agonists in effecting coupling of different receptor subtypes to ...
Shou-Zhen Wang, E. E. El-Fakahany
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Chinese hamster ovary cell lines which stably express individual subtypes of muscarinic acetylcholine receptors (m1-m5) were used to assess the potential selectivity of known muscarinic agonists in effecting coupling of different receptor subtypes to ...
Shou-Zhen Wang, E. E. El-Fakahany
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Muscarinic Agonists as Insecticides and Acaricides
Pesticide Science, 1997A series of known agonists of the mammalian muscarinic receptor were prepared and evaluated for their insecticidal potential. It was discovered that pests such as Nilaparvata lugens (brown planthopper), Nephotettix cincticeps (green leafhopper), Tetranychus urticae (two-spotted spider mite) and Aphis gossypii (cotton aphid) were particularly sensitive ...
Michael R. Dick +2 more
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Journal of Pharmacology and Experimental Therapeutics, 1988
In the guinea pig atria, carbachol, acetylcholine and bethanechol elicited negative inotropic and positive inotropic effects. In the rat atria, a negative inotropic response occurred, but the positive inotropic response was small.
R. Eglen, W. Montgomery, R. Whiting
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In the guinea pig atria, carbachol, acetylcholine and bethanechol elicited negative inotropic and positive inotropic effects. In the rat atria, a negative inotropic response occurred, but the positive inotropic response was small.
R. Eglen, W. Montgomery, R. Whiting
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Tetramethylammonium is a muscarinic agonist in rat heart
American Journal of Physiology-Cell Physiology, 1995Studies were designed to determine if tetramethylammonium (TMA), a quaternary amine that structurally resembles the cationic portion of acetylcholine, can affect cardiac function by acting on muscarinic receptors. Experiments examined effects of this cation on 1) the spontaneous beating rate of right atrial preparations isolated from rats, 2) force of
R H, Kennedy +5 more
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Muscarinic agonist receptor subtypes in aging rat brain
Neurobiology of Aging, 1982Whole brain homogenates from rats aged 6 months (young) and 24 months (old) showed a decline with age of the pre-synaptic cholinergic marker, choline acetyltransferase, and also of total specific binding sites for the muscarinic antagonist L(-)quinuclidinyl benzilate (L-QNB).
Briggs, Roger S. +2 more
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Blockade of muscarinic receptors by alkylating agonist analogues
Biochemical Society Transactions, 1990F. ( 1987) J. Nrirrochrm. 48. 154159 4. Perry, E. K., Perry, R. H. & Tomlinson, B. E. (1982) Neurosci. Lett. 29,303-307 5. Hohorst, H.-J. ( 1965) in Methods of Etizymcitic Anulysis (Bergmeyer H.-U., ed.). pp. 266-270, Academic Press, New York 6. Hardy, J. A,, Wester, P.. Winblad. B.. Gezelius, C.. Bring. G . & Eriksson, A. ( 1985) J. Neitrul7rutism. 61,
E C, Hulme +4 more
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CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment
This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...Abraham, Fisher, Allan I, Levey
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Potential Role of Muscarinic Agonists in Alzheimerʼs Disease
Drugs & Aging, 1997Alzheimer's disease (AD) is a common neurodegenerative disorder and a leading cause of death among the elderly. Recent advances in our understanding of the neurobiology of AD have provided scientific groundwork for the development of potentially more effective and less toxic treatment strategies for the disease.
E E, Avery, L D, Baker, S, Asthana
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Binding of agonists and antagonists to muscarinic receptors
Journal of Supramolecular Structure, 1976AbstractThe binding of one irreversible and two reversible radioactive antagonists to muscarinic receptors in synaptosome preparations of rat cerebral cortex has been studied. The ligands all bind to the same receptor pool and directly and competitively yield self‐consistent binding constants closely similar to those obtained by pharmacological methods
N J, Birdsall +3 more
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Characterization of muscarinic agonists in recombinant cell lines
Life Sciences, 1993Using recombinant CHO cells that express Hm1-Hm5 receptors, reference muscarinic agonists have been characterized with respect to their activity in receptor binding and second messenger assays. In whole cell [3H]-N-methyl scopolamine binding, no agonist was found to be truly subtype selective, although some showed marked differences between several of ...
R D, Schwarz +5 more
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