Results 241 to 250 of about 386,471 (278)

Muscarinic agonists and antagonists in the treatment of Alzheimer's disease

Il Farmaco, 2001
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activity. Although symptoms of AD have been successfully treated with acetylcholinesterase inhibitors
Vicki L. Coffin, Stuart W. McCombie, William Billard, Robert W. Watkins, Joseph A. Kozlowski, William J. Greenlee, C Liu, Jean E. Lachowicz, Lisa A. Taylor, Vilma Ruperto, Catherine D. Strader, Henry Guzik, Vice Susan F, Herbert Binch, Shengjian Li, Ruth A. Duffy, Derek B. Lowe, H Zhao, Kathleen Cox, Theodros Asberom, R Crosby, Gouwei Zhou, Jennifer Ford, John W. Clader   +23 more
openaire   +3 more sources

Blockade of muscarinic receptors by alkylating agonist analogues

Biochemical Society Transactions, 1990
F. ( 1987) J. Nrirrochrm. 48. 154159 4. Perry, E. K., Perry, R. H. & Tomlinson, B. E. (1982) Neurosci. Lett. 29,303-307 5. Hohorst, H.-J. ( 1965) in Methods of Etizymcitic Anulysis (Bergmeyer H.-U., ed.). pp. 266-270, Academic Press, New York 6. Hardy, J. A,, Wester, P.. Winblad. B.. Gezelius, C.. Bring. G . & Eriksson, A. ( 1985) J. Neitrul7rutism. 61,
Nigel J. M. Birdsall, Edward C. Hulme, Carol A. M. Curtis, Tracy A. Spalding, John E. T. Corrie   +4 more
openaire   +3 more sources

Striatal muscarinic receptors: Regulation by dopaminergic agonists

Life Sciences, 1981
Abstract The effects of apomorphine on the binding properties of striatal muscarinic receptors were investigated using the specific muscarinic antagonist, [ 3 H](−)3-quinuclidinyl benzilate ([ 3 H](−)QNB). When binding measurements were made in 50 mM sodium/HEPES buffer, pH 7.4, containing Mg +2 , the binding of [ 3 H](−)QNB was consistent with the ...
William R. Roeske, Frederick J. Ehlert, Henry I. Yamamura   +2 more
openaire   +3 more sources

The Role of Muscarinic K+ Channels in the Negative Chronotropic Effect of a Muscarinic Agonist

The Journal of Pharmacology and Experimental Therapeutics, 2002
Acetylcholine causes bradycardia through M2 muscarinic receptors in sinoatrial node cells. I examined with electrocardiogram how the muscarinic K(+) (K(ACh)) channel participates in the sinus bradycardia induced by a muscarinic agonist in the Langendorff preparation of rabbit hearts.
openaire   +2 more sources

Quinuclidinone O-Alkynyloximes with muscarinic agonist activity

Bioorganic & Medicinal Chemistry, 2002
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Somanadhan, B., Loke, W.-K., Sim, M.-K., Go, M.-L.   +3 more
openaire   +4 more sources

The effect of muscarinic agonists and selective receptor subtype antagonists on the contractile response of the isolated rhesus monkey ciliary muscle.

Experimental Eye Research, 1994
There are ultrastructural and histochemical differences between the longitudinal (putatively more relevant to outflow facility) and circular (putatively more relevant to accommodation) portions of the primate ciliary muscle.
J. Poyer, B. Gabelt, P. Kaufman
semanticscholar   +1 more source

Cation channel activated by muscarinic agonists on porcine adrenal chromaffin cells.

American Journal of Physiology, 1995
A large portion (70%) of the secretory response to muscarinic agonists in porcine adrenal chromaffin cells has previously been shown to be dependent on extracellular Ca2+ (Xu et al., J. Neurochem. 56: 1899-1896, 1991).
E. Forsberg, Q. Li, Y. Xu
semanticscholar   +1 more source

Muscarinic Agonists and the Treatment of Alzheimer's Disease

Neurology, 1997
Muscarinic Agonists and the Treatment of Alzheimer's Disease edited by Abraham Fisher , 193 pp., ill., Austin, TX, R.G. Landes 1996, $79.95. Although the search for adequate treatment of Alzheimer's disease has been frustrating, a modest response to tacrine and new cholinesterase inhibitors has been partial vindication for therapy based on the ...
openaire   +2 more sources

Muscarinic Receptor Subtypes and the Selectivity of Agonists and Antagonists

Pharmacology, 1988
Receptors may be grouped into superfamilies, according to their mechanism. Muscarinic receptors belong to one such superfamily, that of the G-protein coupled receptors. Subtypes of muscarinic receptors may be defined according to their primary amino acid sequence, their mechanism and their pharmacology.
Nigel J. M. Birdsall, David R. Poyner, Mark Wheatley, E.K. Pedder, Carol A. M. Curtis, P. Eveleigh, Edward C. Hulme   +6 more
openaire   +3 more sources

Muscarinic agonists for the treatment of Alzheimer's disease: progress and perspectives.

Expert Opinion on Investigational Drugs, 1997
Much interest has focused on the development of selective muscarinic agonists for the treatment of Alzheimer's disease (AD). Cholinergic replacement therapy is thought to be beneficial in alleviating some of the cognitive dysfunctions in this disorder ...
A. Fisher
semanticscholar   +1 more source