Results 21 to 30 of about 556,071 (288)

The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats. [PDF]

PLoS ONE, 2011
Adenosine, a catabolite of ATP, displays a wide variety of effects in the heart including regulation of cardiac response to myocardial ischemia and reperfusion injury.
Lei Sun, Dong-Ling Li, Mei Zhao, Xi He, Xiao-Jiang Yu, Yi Miao, Hao Wang, Jun Ren, Wei-Jin Zang   +8 more
doaj   +1 more source

Long-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromide

Journal of Asthma and Allergy, 2015
Background Randomized controlled trials indicate that addition of a long-acting muscarinic antagonist (LAMA) such as tiotropium may improve asthma control and reduce exacerbation risk in patients with poorly controlled asthma, but broader clinical ...
D. Price, A. Kaplan, Rupert C Jones, Daryl Freeman, A. Burden, S. Gould, J. von Ziegenweidt, Muzammil Ali, C. King, M. Thomas   +9 more
semanticscholar   +1 more source

Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis

International Journal of COPD, 2015
Background Randomized, controlled trials comparing long-acting muscarinic antagonist (LAMA) efficacy in COPD are limited. This network meta-analysis (NMA) assessed the relative efficacy of tiotropium 18 µg once-daily (OD) and newer agents (aclidinium 400
A. Ismaila, E. Huisman, Y. Punekar, A. Karabis   +3 more
semanticscholar   +1 more source

Revefenacin: Drug review

Journal of Clinical and Biomedical Sciences, 2018
Revefenacin, a long-acting muscarinic receptor antagonist was approved by US Food and Drug Administration in November 2018 for the maintenance treatment of patients with Chronic Obstructive Pulmonary Disease (COPD).
Bhuvana K
doaj   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

Activation of muscarinic acetylcholine receptors elicits pigment granule dispersion in retinal pigment epithelium isolated from bluegill

BMC Neuroscience, 2004
Background In fish, melanin pigment granules in the retinal pigment epithelium disperse into apical projections as part of the suite of responses the eye makes to bright light conditions.
Crittenden Elizabeth L, González Alfredo, García Dana M   +2 more
doaj   +1 more source

Structural insights into the subtype-selective antagonist binding to the M2 muscarinic receptor

Nature Chemical Biology, 2018
Human muscarinic receptor M2 is one of the five subtypes of muscarinic receptors belonging to the family of G-protein-coupled receptors. Muscarinic receptors are targets for multiple neurodegenerative diseases.
Ryoji Suno, Sangbae Lee, S. Maeda, S. Yasuda, K. Yamashita, K. Hirata, S. Horita, M. Tawaramoto, Hirokazu Tsujimoto, T. Murata, M. Kinoshita, Masaki Yamamoto, B. Kobilka, N. Vaidehi, S. Iwata, Takuya Kobayashi   +15 more
semanticscholar   +1 more source

Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs*

Journal of Biological Chemistry, 2016
Although rhodopsin-like G protein-coupled receptors can exist as both monomers and non-covalently associated dimers/oligomers, the steady-state proportion of each form and whether this is regulated by receptor ligands are unknown. Herein we address these
J. Pediani, R. Ward, A. Godin, Sara Marsango, G. Milligan   +4 more
semanticscholar   +1 more source

Hippocampus and basal forebrain volumes modulate effects of anticholinergic treatment on delayed recall in healthy older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Volumes of hippocampus and cholinergic basal forebrain are associated with delayed recall performance and may modulate the effect of a muscarinic receptor antagonist on delayed recall in healthy volunteers. Methods We studied 15 older adults
Stefan J. Teipel, Davide Bruno, Michel J. Grothe, Jay Nierenberg, Nunzio Pomara   +4 more
doaj   +1 more source

Delivery characteristics of a low-resistance dry-powder inhaler used to deliver the long-acting muscarinic antagonist glycopyrronium*

Journal of Drug Assessment, 2013
Objectives: The long-acting muscarinic antagonist (LAMA) glycopyrronium (NVA237) has recently been approved as a once-daily treatment for COPD. The objectives of this study were to determine the dose delivery characteristics of glycopyrronium and compare
P. Colthorpe, T. Voshaar, Thomas Kieckbusch, E. Cuoghi, J. Jauernig   +4 more
semanticscholar   +1 more source