Results 21 to 30 of about 27,985 (262)

Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice

Journal of Pharmacological Sciences, 2020
Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the
Keisuke Migita, Akiko Nishimura, Fumihiro Eto, Kohei Koga, Taichi Matsumoto, Kazuki Terada, Shuji Hara, Kenji Honda   +7 more
doaj   +1 more source

Methylene Blue Is a Muscarinic Antagonist in Cardiac Myocytes [PDF]

Molecular Pharmacology, 1997
We studied the mechanism of action of methylene blue (Mblue), a putative guanylyl cyclase inhibitor, on the L-type calcium current (ICa) and the muscarinic activated K+ current (IK,ACh) in rat ventricular and atrial myocytes, respectively, and on the binding of [3H]quinuclidinyl benzylate in rat ventricular membranes.
Abi-Gerges, Najah, Eschenhagen, Thomas, Hove-Madsen, Leif, Fischmeister, Rodolphe, Mery, Pierre-François   +4 more
openaire   +2 more sources

Revefenacin: Drug review

Journal of Clinical and Biomedical Sciences, 2018
Revefenacin, a long-acting muscarinic receptor antagonist was approved by US Food and Drug Administration in November 2018 for the maintenance treatment of patients with Chronic Obstructive Pulmonary Disease (COPD).
Bhuvana K
doaj   +1 more source

Hippocampus and basal forebrain volumes modulate effects of anticholinergic treatment on delayed recall in healthy older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Volumes of hippocampus and cholinergic basal forebrain are associated with delayed recall performance and may modulate the effect of a muscarinic receptor antagonist on delayed recall in healthy volunteers. Methods We studied 15 older adults
Stefan J. Teipel, Davide Bruno, Michel J. Grothe, Jay Nierenberg, Nunzio Pomara   +4 more
doaj   +1 more source

Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]

PLoS ONE, 2014
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow, Kelly Jiang, Alipi V Naydenov, Joshua H Le, Nephi Stella, Neil M Nathanson   +5 more
doaj   +1 more source

Data on the safety and tolerability of revefenacin, in patients with moderate to very severe chronic obstructive pulmonary disease

Data in Brief, 2019
This article contains information on the experimental design and methods on how the safety and tolerability data concerning patients with moderate to very severe chronic obstructive pulmonary disease (COPD) were obtained.
James Donohue, Edward Kerwin, Sanjay Sethi, Brett Haumann, Srikanth Pendyala, Lorna Dean, Chris N. Barnes, Edmund J. Moran, Glenn Crater   +8 more
doaj   +1 more source

Single inhaler triple therapy in COPD – all that glitters is not gold

Monaldi Archives for Chest Disease, 2021
Dear Editor, The recent studies on combination triple therapy of inhaled corticosteroid, long acting beta2 agonist and long-acting muscarinic antagonist (ICS-LABA-LAMA) in COPD have consistently demonstrated an improvement in exacerbation frequency and/
Kartik Deshmukh, Arjun Khanna
doaj   +1 more source

Muscarinic antagonist effects on executive control of attention [PDF]

The International Journal of Neuropsychopharmacology, 2009
Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic ...
Thienel, Renate, Kellermann, Thilo, Kircher, Tilo, Schall, Ulrich, Voss, Bianca, Reske, Martina, Halfter, Sarah, Sheldrick, Abigail J., Radenbach, Katrin, Habel, Ute, Shah, Nadim Jon   +10 more
openaire   +4 more sources

Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function

eLife, 2022
The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Such dysfunction may be caused by aberrant interactions of different neuromodulators with NMDARs, which could explain clinical ...
Lilian Aline Weber, Sara Tomiello, Dario Schöbi, Katharina V Wellstein, Daniel Mueller, Sandra Iglesias, Klaas Enno Stephan   +6 more
doaj   +1 more source

Pembrolizumab-associated bronchiolitis in an elderly lung cancer patient required the treatment with an inhaled corticosteroid, erythromycin and bronchodilators

Respiratory Medicine Case Reports, 2019
Immune checkpoint inhibitors (ICIs) have been used to treat lung cancer. Several types of ICI-related interstitial lung diseases have been reported, including organizing pneumonia, non-specific interstitial pneumonia, and diffuse alveolar damage. However,
Takafumi Yamaya, Hwang Moon Hee, Takayuki Aoyagi, Tatsuya Ogimoto, Naoki Yamada, Ryoichi Ishikawa, Erika Nakai, Kenta Nishi, Chie Yoshimura, Yasuo Nishizaka   +9 more
doaj   +1 more source