Results 21 to 30 of about 28,121 (145)

Hippocampus and basal forebrain volumes modulate effects of anticholinergic treatment on delayed recall in healthy older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Volumes of hippocampus and cholinergic basal forebrain are associated with delayed recall performance and may modulate the effect of a muscarinic receptor antagonist on delayed recall in healthy volunteers. Methods We studied 15 older adults
Stefan J. Teipel, Davide Bruno, Michel J. Grothe, Jay Nierenberg, Nunzio Pomara   +4 more
doaj   +1 more source

Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]

PLoS ONE, 2014
Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow, Kelly Jiang, Alipi V Naydenov, Joshua H Le, Nephi Stella, Neil M Nathanson   +5 more
doaj   +1 more source

Data on the safety and tolerability of revefenacin, in patients with moderate to very severe chronic obstructive pulmonary disease

Data in Brief, 2019
This article contains information on the experimental design and methods on how the safety and tolerability data concerning patients with moderate to very severe chronic obstructive pulmonary disease (COPD) were obtained.
James Donohue, Edward Kerwin, Sanjay Sethi, Brett Haumann, Srikanth Pendyala, Lorna Dean, Chris N. Barnes, Edmund J. Moran, Glenn Crater   +8 more
doaj   +1 more source

Single inhaler triple therapy in COPD – all that glitters is not gold

Monaldi Archives for Chest Disease, 2021
Dear Editor, The recent studies on combination triple therapy of inhaled corticosteroid, long acting beta2 agonist and long-acting muscarinic antagonist (ICS-LABA-LAMA) in COPD have consistently demonstrated an improvement in exacerbation frequency and/
Kartik Deshmukh, Arjun Khanna
doaj   +1 more source

Pembrolizumab-associated bronchiolitis in an elderly lung cancer patient required the treatment with an inhaled corticosteroid, erythromycin and bronchodilators

Respiratory Medicine Case Reports, 2019
Immune checkpoint inhibitors (ICIs) have been used to treat lung cancer. Several types of ICI-related interstitial lung diseases have been reported, including organizing pneumonia, non-specific interstitial pneumonia, and diffuse alveolar damage. However,
Takafumi Yamaya, Hwang Moon Hee, Takayuki Aoyagi, Tatsuya Ogimoto, Naoki Yamada, Ryoichi Ishikawa, Erika Nakai, Kenta Nishi, Chie Yoshimura, Yasuo Nishizaka   +9 more
doaj   +1 more source

Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function

eLife, 2022
The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Such dysfunction may be caused by aberrant interactions of different neuromodulators with NMDARs, which could explain clinical ...
Lilian Aline Weber, Sara Tomiello, Dario Schöbi, Katharina V Wellstein, Daniel Mueller, Sandra Iglesias, Klaas Enno Stephan   +6 more
doaj   +1 more source

Localization of muscarinic acetylcholine receptor 2 to the intestinal crypt stem cell compartment

Data in Brief, 2017
The data presented in this article are related to the research article entitled “Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine” (E.D. Muise, N. Gandotra, J.J. Tackett, M.C. Bamdad, R.A. Cowles, 2016) [1].
Eleanor D. Muise, Neeru Gandotra, John J. Tackett, Michaela C. Bamdad, Robert A. Cowles   +4 more
doaj   +1 more source

Cholinergic partition cells and lamina X neurons induce a muscarinic-dependent short-term potentiation of commissural glutamatergic inputs in lumbar motoneurons.

Frontiers in Neural Circuits, 2011
Acetylcholine and the activation of muscarinic receptors influence the activity of neural networks generating locomotor behaviour in the mammalian spinal cord.
Sandrine S Bertrand, Jean-René eCazalets   +1 more
doaj   +1 more source

Possible involvement of acetylcholine-mediated inflammation in airway diseases

Allergology International, 2018
Inhaled bronchodilator treatment with a long acting muscarinic antagonist (LAMA) reduces symptoms and the risk of exacerbations in COPD and asthma. However, increasing evidence from cell culture and animal studies suggests that anti-muscarinic drugs ...
Akira Koarai, Masakazu Ichinose
doaj   +1 more source

Pharmaceutical Assessment Suggests Locomotion Hyperactivity in Zebrafish Triggered by Arecoline Might Be Associated with Multiple Muscarinic Acetylcholine Receptors Activation

Toxins, 2021
Arecoline is one of the nicotinic acid-based alkaloids, which is found in the betel nut. In addition to its function as a muscarinic agonist, arecoline exhibits several adverse effects, such as inducing growth retardation and causing developmental ...
Petrus Siregar, Gilbert Audira, Ling-Yi Feng, Jia-Hau Lee, Fiorency Santoso, Wen-Hao Yu, Yu-Heng Lai, Jih-Heng Li, Ying-Ting Lin, Jung-Ren Chen, Chung-Der Hsiao   +10 more
doaj   +1 more source