Results 21 to 30 of about 2,979 (198)
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015 Introduction Volumes of hippocampus and cholinergic basal forebrain are associated with delayed recall performance and may modulate the effect of a muscarinic receptor antagonist on delayed recall in healthy volunteers. Methods We studied 15 older adults
Stefan J. Teipel +4 more
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Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]
PLoS ONE, 2014 Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow +5 more
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Single inhaler triple therapy in COPD – all that glitters is not gold
Monaldi Archives for Chest Disease, 2021 Dear Editor, The recent studies on combination triple therapy of inhaled corticosteroid, long acting beta2 agonist and long-acting muscarinic antagonist (ICS-LABA-LAMA) in COPD have consistently demonstrated an improvement in exacerbation frequency and/
Kartik Deshmukh, Arjun Khanna
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, 2022 CPT: Pharmacometrics &Systems Pharmacology, Volume 11, Issue 12, Page 1556-1559, December 2022.
Ronald Gieschke, Robert Carr
wiley +1 more source
British Journal of Pharmacology, EarlyView., 2023 Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
wiley +1 more source
Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, EarlyView., 2023 Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source
Random Antagonistic Matrices [PDF]
J. Phys. A: Math. Theor. 49 (2016) 375601 (16pp), 2016 The ensemble of antagonistic matrices is introduced and studied. In antagonistic matrices the entries $\mathcal A_{i,j}$ and $\mathcal A_{j,i}$ are real and have opposite signs, or are both zero, and the diagonal is zero. This generalization of antisymmetric matrices is suggested by the linearized dynamics of competitive species in ecology.
arxiv +1 more source
eLife, 2022 The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Such dysfunction may be caused by aberrant interactions of different neuromodulators with NMDARs, which could explain clinical ...
Lilian Aline Weber +6 more
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Sex-specific recombination rates and allele frequencies affect the invasion of sexually antagonistic variation on autosomes [PDF]
Journal of Evolutionary Biology 26 (2013) 2428, 2013 The introduction and persistence of novel sexually antagonistic alleles can depend upon factors that differ between males and females. Understanding the conditions for invasion in a two-locus model can elucidate these processes. For instance, selection can act differently upon the sexes, or sex-linkage can facilitate the invasion of genetic variation ...
arxiv +1 more source
Extreme antagonism arising from gene-environment interactions [PDF]
, 2020 Antagonistic interactions in biological systems, which occur when one perturbation blunts the effect of another, are typically interpreted as evidence that the two perturbations impact the same cellular pathway or function. Yet, this interpretation ignores extreme antagonistic interactions wherein an otherwise deleterious perturbation compensates for ...
arxiv +1 more source