Results 61 to 70 of about 2,979 (198)

The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding

open access: yesBrain Sciences, 2020
Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects is not fully understood, but may involve altered cholinergic neurotransmission. This study
Sarah S. Ch’ng   +9 more
doaj   +1 more source

Harnessing Jasminum Bioactive Compounds: Updated Insights for Therapeutic and Food Preservation Innovations

open access: yesFood Frontiers, EarlyView.
Jasminum bioactives improve food preservation by providing antimicrobial and antioxidant effects, especially when incorporated into active packaging, edible films, and nanoformulations that enhance stability and controlled release. They also offer many pharmacological benefits, including anti‐inflammatory, neuroprotective, and wound‐healing properties.
Antonio Rescigno   +17 more
wiley   +1 more source

Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease

open access: yesJournal of Experimental Pharmacology, 2020
Josuel Ora,1 Angelo Coppola,2 Mario Cazzola,3 Luigino Calzetta,4 Paola Rogliani1,3 1Division of Respiratory Medicine, University Hospital Tor Vergata, Rome, Italy; 2Division of Respiratory Medicine, San Filippo Neri Hospital, Rome, Italy; 3Department of ...
Ora J   +4 more
doaj  

Effect of Neuromodulation of Short-Term Plasticity on Information Processing in Hippocampal Interneuron Synapses [PDF]

open access: yesarXiv, 2018
Neurons in a micro-circuit connected by chemical synapses can have their connectivity affected by the prior activity of the cells. The number of synapses available for releasing neurotransmitter can be decreased by repetitive activation through depletion of readily releasable neurotransmitter (NT), or increased through facilitation, where the ...
arxiv  

Weakly Coupled Oscillators in a Slowly Varying World [PDF]

open access: yes, 2016
We extend the theory of weakly coupled oscillators to incorporate slowly varying inputs and parameters. We employ a combination of regular perturbation and an adiabatic approximation to derive equations for the phase-difference between a pair of oscillators. We apply this to the simple Hopf oscillator and then to a biophysical model.
arxiv   +1 more source

Profile of inhaled glycopyrronium bromide as monotherapy and in fixed-dose combination with indacaterol maleate for the treatment of COPD

open access: yesInternational Journal of COPD, 2015
Anoop Prakash,1 K Suresh Babu,2 Jaymin B Morjaria1,31Department of Respiratory Medicine, Castle Hill Hospital, Cottingham, 2Department of Respiratory Medicine, Queen Alexandra Hospital, Cosham, Portsmouth, 3Department of Academic Respiratory Medicine ...
Prakash A, Babu KS, Morjaria JB
doaj  

Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice

open access: yesJournal of Pharmacological Sciences, 2020
Cholinergic neurons play an important role in the higher functions of the brain, such as the memory, cognition, and nociception. However, the exact mechanism behind how the stimulation of all the muscarinic M1 receptors in the entire brain results in the
Keisuke Migita   +7 more
doaj  

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou   +6 more
wiley   +1 more source

Altruism and Antagonistic Pleiotropy in Penna Ageing Model [PDF]

open access: yesarXiv, 2004
The Penna ageing model is based on mutation accumulation theory. We show that it also allows for self-organization of antagonistic pleiotropy which helps at young age at the expense of old age. This can be interpreted as emergence of altruism.
arxiv  

Light‐Activated Pharmacological Tools for Exploring the Cholinergic System

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni   +5 more
wiley   +1 more source

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