Bitopic binding mode of an M1 muscarinic acetylcholine receptor agonist associated with adverse clinical trial outcomes [PDF]
, 2018 The realisation of the therapeutic potential of targeting the M1 muscarinic acetylcholine receptor (M1 mAChR) for the treatment of cognitive decline in Alzheimer's disease has prompted the discovery of M1 mAChR ligands showing efficacy in alleviating ...
Bradley, Sophie J. +14 more
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Might It Be Appropriate to Anticipate the Use of Long-Acting Muscarinic Antagonists in Asthma? [PDF]
Drugs, 2023 Cazzola M, Rogliani P, Matera MG.
europepmc +1 more source
The therapeutic potential of allosteric ligands for free fatty acid sensitive GPCRs [PDF]
, 2013 G protein coupled receptors (GPCRs) are the most historically successful therapeutic targets. Despite this success there are many important aspects of GPCR pharmacology and function that have yet to be exploited to their full therapeutic potential.
Hudson, Brian D. +2 more
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Methylene Blue Is a Muscarinic Antagonist in Cardiac Myocytes
Molecular Pharmacology, 1997 We studied the mechanism of action of methylene blue (Mblue), a putative guanylyl cyclase inhibitor, on the L-type calcium current (ICa) and the muscarinic activated K+ current (IK,ACh) in rat ventricular and atrial myocytes, respectively, and on the binding of [3H]quinuclidinyl benzylate in rat ventricular membranes.
Abi-Gerges, Najah +4 more
openaire +2 more sources
The once-daily fixed-dose combination of olodaterol and tiotropium in the management of COPD : current evidence and future prospects [PDF]
, 2019 Long-acting bronchodilators are the cornerstone of pharmacologic treatment of chronic obstructive pulmonary disease (COPD). Spiolto (R) or Stiolto (R) is a fixed-dose combination (FDC) containing two long-acting bronchodilators, the long-acting ...
Brusselle, Guy, Derom, Eric, Joos, Guy
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Inhaled corticosteroids with combination inhaled long-acting beta2-agonists and long-acting muscarinic antagonists for chronic obstructive pulmonary disease. [PDF]
Cochrane Database Syst Rev, 2023 van Geffen WH +3 more
europepmc +1 more source
The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]
, 2018 Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth +6 more
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Muscarinic antagonists impair multiple aspects of operant discrimination learning and performance. [PDF]
Neurosci Lett, 2023 Yousuf H +3 more
europepmc +1 more source
Mutual Control of Cholinergic and Low-Threshold Spike Interneurons in the Striatum [PDF]
, 2016 The striatum is the largest nucleus of the basal ganglia and is crucially involved in action selection and reward processing. Cortical and thalamic inputs to the striatum are processed by local networks in which several classes of interneurons play an ...
Ade +49 more
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Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium. [PDF]
BMC Pulm Med, 2022 Katsumata M +17 more
europepmc +1 more source