Results 11 to 20 of about 22,691 (214)
Biomedicines, 2023 Psychosis that occurs over the course of Alzheimer’s disease (AD) is associated with increased caregiver burden and a more rapid cognitive and functional decline.
Heidy Jimenez +9 more
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Toxins, 2021 Arecoline is one of the nicotinic acid-based alkaloids, which is found in the betel nut. In addition to its function as a muscarinic agonist, arecoline exhibits several adverse effects, such as inducing growth retardation and causing developmental ...
Petrus Siregar +10 more
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Communications Biology, 2021 Katayama et al. report a vibrational spectroscopic study using ATR–FTIR of the human M2 muscarinic acetylcholine receptor (M2R). Their work involves an extensive comparison of agonists, antagonists, and inverse agonists, in which they show that they C ...
Kota Katayama +8 more
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Clinical Factors Associated With Dose Escalation of Solifenacin for the Treatment of Overactive Bladder in Real Life Practice [PDF]
International Neurourology Journal, 2014 PurposeTo determine the baseline clinical characteristics associated with dose escalation of solifenacin in patients with overactive bladder (OAB).MethodsWe analyzed the data of patients with OAB (micturition frequency ≥8/day and urgency ≥1/day) who were
Ji-Youn Chun +5 more
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ACSEE: Antagonistic Crowd Simulation Model with Emotional Contagion and Evolutionary Game Theory [PDF]
IEEE Transactions on Affective Computing (2019), 2019 Antagonistic crowd behaviors are often observed in cases of serious conflict. Antagonistic emotions, which is the typical psychological state of agents in different roles (i.e. cops, activists, and civilians) in crowd violent scenes, and the way they spread through contagion in a crowd are important causes of crowd antagonistic behaviors.
arxiv +1 more source
Methylene Blue Is a Muscarinic Antagonist in Cardiac Myocytes [PDF]
Molecular Pharmacology, 1997 We studied the mechanism of action of methylene blue (Mblue), a putative guanylyl cyclase inhibitor, on the L-type calcium current (ICa) and the muscarinic activated K+ current (IK,ACh) in rat ventricular and atrial myocytes, respectively, and on the binding of [3H]quinuclidinyl benzylate in rat ventricular membranes.
Abi-Gerges, Najah +4 more
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Frontiers in Neuroscience, 2018 The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse ...
Mohammad G. Sabbir +3 more
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Percolation on interacting, antagonistic networks [PDF]
J. Stat. Mech. (2013) P05005, 2012 Recently, new results on percolation of interdependent networks have shown that the percolation transition can be first order. In this paper we show that, when considering antagonistic interactions between interacting networks, the percolation process might present a bistability of the equilibrium solution.
arxiv +1 more source
The structural study of mutation-induced inactivation of human muscarinic receptor M4
IUCrJ, 2020 Human muscarinic receptor M4 belongs to the class A subfamily of the G-protein-coupled receptors (GPCRs). M4 has emerged as an attractive drug target for the treatment of Alzheimer's disease and schizophrenia.
Jingjing Wang +11 more
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Percolation on interdependent networks with a fraction of antagonistic interactions [PDF]
Journal of Statistical Physics, 152,1069 (2013), 2013 Recently, the percolation transition has been characterized on interacting networks both in presence of interdependent and antagonistic interactions. Here we characterize the phase diagram of the percolation transition in two Poisson interdependent networks with a percentage q of antagonistic nodes. We show that this system can present a bistability of
arxiv +1 more source