Results 221 to 230 of about 556,376 (281)

Role of muscarinic antagonists in asthma therapy

Expert Review of Respiratory Medicine, 2017
Higher parasympathetic tone has been reported in asthmatics. In general, cholinergic contractile tone is increased by airway inflammation associated with asthma. Nevertheless, the role of muscarinic antagonists for the treatment of asthma has not yet been clearly defined.
M. Cazzola, J. Ora, P. Rogliani, M. Matera   +3 more
semanticscholar   +6 more sources

Long-acting muscarinic antagonists

Expert Review of Clinical Pharmacology, 2015
Chronic obstructive pulmonary disease (COPD) is a major cause of death and disability worldwide. Inhaled bronchodilators are the mainstay of COPD pharmacological treatment. Long-acting muscarinic antagonists (LAMAs) are a major class of inhaled bronchodilators.
A. Melani
semanticscholar   +3 more sources

Muscarinic Receptor Antagonists.

Handbook of Experimental Pharmacology, 2016
Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
M. Matera, M. Cazzola
semanticscholar   +4 more sources

Long‐acting muscarinic antagonists and small airways in asthma: Which link?

Allergy. European Journal of Allergy and Clinical Immunology, 2021
Involvement of small airways, those of
M. Cazzola, L. Calzetta, M. Matera
semanticscholar   +1 more source

Muscarinic receptor agonists and antagonists [PDF]

Expert Opinion on Therapeutic Patents, 1999
Although four different subtypes of the muscarinic acetylcholine (ACh) receptor with functional correlates are known to exist (function for M5 is still unclear), all muscarinic agonists and antagon...
Darius P. Zlotos, Wiebke Bender, Ulrike Holzgrabe   +2 more
openaire   +1 more source

Selective muscarinic receptor antagonists

Trends in Pharmacological Sciences, 1984
to ex- plain the anomalous binding of cholin- ergic agonists to brain receptors~ were later demonstrated with the seEective muscarinic antagonist, pirenzepine 2. Interestingly, the search for selective antagonists, which usually follows the acceptance of a concept, antedated by many years the notion of heterogeneity of rmecarinic receptors. Intuitively
R. Hammer, A. Giachetti
openaire   +2 more sources

Selective Muscarinic Receptor Agonists and Antagonists

Pharmacology & Toxicology, 1996
Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
Richard M. Eglen, Nikki Watson
openaire   +2 more sources

Muscarinic receptor antagonists for overactive bladder

BJU International, 2007
From time to time we publish a full review of drugs that are available for the treatment of common conditions. In this issue, the review is written by two of the leading authorities in the world, Paul Abrams and Karl‐Erik Andersson, on the topic of overactive bladder and antimuscarinic agents.
Karl-Erik Andersson, Paul Abrams
openaire   +3 more sources

Design and synthesis of a fluorescent muscarinic antagonist

Bioorganic & Medicinal Chemistry Letters, 2008
The design and concise synthesis of a fluorescent tolterodine-BODIPY (boron dipyrromethene) conjugate is described which possesses potent antimuscarinic activity. This derivative illustrates proof-of-concept for the preparation of other useful fluorophoric antimuscarinic agents which have potential utility in receptor occupancy studies and high ...
Carolyn Napier, J. W. Watson, Lyn H. Jones, Sasha Sreckovic, Amy Randall, Mike Trevethick   +5 more
openaire   +3 more sources