Results 221 to 230 of about 687,004 (308)

Role of muscarinic antagonists in asthma therapy

Expert Review of Respiratory Medicine, 2017
Higher parasympathetic tone has been reported in asthmatics. In general, cholinergic contractile tone is increased by airway inflammation associated with asthma. Nevertheless, the role of muscarinic antagonists for the treatment of asthma has not yet been clearly defined.
M. Cazzola, J. Ora, P. Rogliani, M. Matera   +3 more
semanticscholar   +6 more sources

Long‐acting muscarinic antagonists and small airways in asthma: Which link?

Allergy. European Journal of Allergy and Clinical Immunology, 2021
Involvement of small airways, those of
M. Cazzola, L. Calzetta, M. Matera
semanticscholar   +1 more source

Selective muscarinic receptor antagonists

Trends in Pharmacological Sciences, 1984
to ex- plain the anomalous binding of cholin- ergic agonists to brain receptors~ were later demonstrated with the seEective muscarinic antagonist, pirenzepine 2. Interestingly, the search for selective antagonists, which usually follows the acceptance of a concept, antedated by many years the notion of heterogeneity of rmecarinic receptors. Intuitively
R. Hammer, A. Giachetti
openaire   +3 more sources

Selective Muscarinic Receptor Agonists and Antagonists

Pharmacology & Toxicology, 1996
Abstract:Muscarinic receptors are composed of a family of four subtypes each of which can be distinguished pharmacologically and structurally. The physiological role of each subtype in the central and peripheral nervous systems remains to be clarified, due, in part, to a lack of agonists and antagonists with adequate subtype selectivity.
R M, Eglen, N, Watson
openaire   +2 more sources

Muscarinic receptor antagonists activate ERK‐CREB signaling to augment neurite outgrowth of adult sensory neurons

Neuropharmacology, 2018
A major cellular effector activated by G protein coupled receptors is extracellular signal‐regulated kinase (ERK). The ERK signaling cascade regulates a variety of cellular processes including growth and proliferation.
M. Sabbir, P. Fernyhough
semanticscholar   +1 more source

Muscarinic receptor antagonists for overactive bladder

BJU International, 2007
From time to time we publish a full review of drugs that are available for the treatment of common conditions. In this issue, the review is written by two of the leading authorities in the world, Paul Abrams and Karl‐Erik Andersson, on the topic of overactive bladder and antimuscarinic agents.
Paul, Abrams, Karl-Erik, Andersson
openaire   +2 more sources

Quinuclidin-2-ene - based muscarinic antagonists

Life Sciences, 1995
A series of achiral 3-heteroaryl substituted quinuclidin-2-ene derivatives and related compounds have been synthesized by facile methods. The compounds were evaluated for muscarinic and antimuscarinic properties in receptor binding studies using (-)-[3H]-QNB as the radioligand and in a functional assay using isolated guinea pig urinary bladder.
U, Hacksell, B M, Nilsson, G, Nordvall, G, Johansson, S, Sundquist, L, Nilvebrant   +5 more
openaire   +2 more sources

MUSCARINIC RECEPTOR ANTAGONISTS

1991
A muscarinic receptor antagonist of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is N or (a) where R is H, halo or C1-C4 alkyl; R is H or C1-C4 alkyl; R is H or C1-C4 alkyl; Y is a direct link, O or S; m is an integer of from 1 to 4; n is 2 or 3; and R is 1- or 2-naphthyl or a group of formula (b), (c) or Het where R and R are ...
PFIZER LTD, PFIZER
openaire   +2 more sources

Muscarinic receptor agonists and antagonists

Expert Opinion on Therapeutic Patents, 1999
Although four different subtypes of the muscarinic acetylcholine (ACh) receptor with functional correlates are known to exist (function for M5 is still unclear), all muscarinic agonists and antagon...
Darius P Zlotos, Wiebke Bender, Ulrike Holzgrabe   +2 more
openaire   +1 more source

Selective muscarinic receptor antagonists for airway diseases

Current Opinion in Pharmacology, 2001
Airway tone and airway hyperreactivity are mediated by the parasympathetic nerves that release acetylcholine onto muscarinic receptors (M1-M5). Stimulation of M1 and M3 muscarinic receptors causes bronchoconstriction. The M1 muscarinic receptor is excitatory, and facilitates neuronal transmission at the parasympathetic ganglion.
A M, Lee, D B, Jacoby, A D, Fryer
openaire   +2 more sources