Results 21 to 30 of about 22,691 (214)

Single Inhaler LABA/LAMA for COPD

Frontiers in Pharmacology, 2019
Chronic obstructive pulmonary disease (COPD) is a common disabling disease characterized by progressive airflow obstruction. Great efforts were spent in the development of drugs able to improve symptoms, quality of life, reduce exacerbations ...
Mario Malerba, Mario Malerba, Valentina Foci, Valentina Foci, Filippo Patrucco, Filippo Patrucco, Patrizia Pochetti, Patrizia Pochetti, Matteo Nardin, Corrado Pelaia, Alessandro Radaeli   +10 more
doaj   +1 more source

Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

Advances in Pharmacological Sciences, 2009
In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve ...
Anders T. Ryberg, Ondrej Soukup, Gunnar Tobin   +2 more
doaj   +1 more source

Combination therapy with indacaterol and glycopyrronium bromide in the management of COPD: an update on the evidence for efficacy and safety

Therapeutic Advances in Respiratory Disease, 2015
The international guidelines on chronic obstructive pulmonary disease (COPD) recommend inhaled bronchodilators for maintenance treatment of the disease. These drugs include β2-agonists and muscarinic antagonists, which are both available as short-acting ...
Erminia Ridolo, Marcello Montagni, Gian Galeazzo Riario-Sforza, Marco Baroni, Cristoforo Incorvaia   +4 more
doaj   +1 more source

Dementia patients have greater anti-cholinergic drug burden on discharge from hospital: A multicentre cross-sectional study

European Psychiatry, 2021
Introduction Anticholinergic medications block cholinergic transmission. The central effects of anticholinergic drugs can be particularly marked in patients with dementia.
J. Randall, A. Hook, C-M. Grubb, N. Ellis, J. Wellington, A. Hemmad, A. Zerdelis, B. Geers, B. Sykes, C. Auty, C. Vinchenzo, C. Thorburn, D. Asogbon, E. Granger, H. Boagey, J. Raphael, K. Patel, K. Bhargava, M.-K. Dolley, M. Maden, M. Shah, Q. Lee, R. Vaidya, S. Sehdev, S. Barai, S. Roche, U. Khalid, J. Harrison, D. Codling   +28 more
doaj   +1 more source

Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study [PDF]

Korean Journal of Anesthesiology, 2020
Background Catheter-related bladder discomfort (CRBD) is a frequent complaint after awakening from anesthesia in patients receiving perioperative bladder catheterization.
Vinit Kumar Srivastava, Sanjay Agrawal, Sweta Anil Deshmukh, Febin Noushad, Saima Khan, Raj Kumar   +5 more
doaj   +1 more source

Random Antagonistic Matrices [PDF]

J. Phys. A: Math. Theor. 49 (2016) 375601 (16pp), 2016
The ensemble of antagonistic matrices is introduced and studied. In antagonistic matrices the entries $\mathcal A_{i,j}$ and $\mathcal A_{j,i}$ are real and have opposite signs, or are both zero, and the diagonal is zero. This generalization of antisymmetric matrices is suggested by the linearized dynamics of competitive species in ecology.
arxiv   +1 more source

Muscarinic antagonist effects on executive control of attention [PDF]

The International Journal of Neuropsychopharmacology, 2009
Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic ...
Thienel, Renate, Kellermann, Thilo, Kircher, Tilo, Schall, Ulrich, Voss, Bianca, Reske, Martina, Halfter, Sarah, Sheldrick, Abigail J., Radenbach, Katrin, Habel, Ute, Shah, Nadim Jon   +10 more
openaire   +4 more sources

Sex-specific recombination rates and allele frequencies affect the invasion of sexually antagonistic variation on autosomes [PDF]

Journal of Evolutionary Biology 26 (2013) 2428, 2013
The introduction and persistence of novel sexually antagonistic alleles can depend upon factors that differ between males and females. Understanding the conditions for invasion in a two-locus model can elucidate these processes. For instance, selection can act differently upon the sexes, or sex-linkage can facilitate the invasion of genetic variation ...
arxiv   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways

Cells, 2023
Bronchodilators and anti-inflammatory agents are the mainstream treatments in chronic obstructive and pulmonary disease (COPD) and asthma.
Joseph Antony Jude, Ian Dainty, Nikhil Karmacharya, William Jester, Reynold Panettieri   +4 more
doaj   +1 more source

Extreme antagonism arising from gene-environment interactions [PDF]

, 2020
Antagonistic interactions in biological systems, which occur when one perturbation blunts the effect of another, are typically interpreted as evidence that the two perturbations impact the same cellular pathway or function. Yet, this interpretation ignores extreme antagonistic interactions wherein an otherwise deleterious perturbation compensates for ...
arxiv   +1 more source