(R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication. [PDF]
Neuropharmacology, 2023 Aracava Y, Albuquerque EX, Pereira EFR.
europepmc +1 more source
The muscarinic receptor subtype in mouse pancreatic B‐cells [PDF]
, 1988 Jean‐Claude Henquin, Myriam Nenquin
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Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, Volume 45, Issue 4, Page 1251-1274, July 2025.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans. [PDF]
Front Nucl Med, 2022 Cselényi Z +12 more
europepmc +1 more source
Muscarinic activity of McN‐A‐343 and its value in muscarinic receptor classification [PDF]
, 1987 Richard M. Eglen +3 more
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British Journal of Pharmacology, Volume 182, Issue 14, Page 3044-3067, July 2025.Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi +6 more
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The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. [PDF]
Proc Natl Acad Sci U S A, 2022 Marsango S +10 more
europepmc +1 more source
Impaired cardiac muscarinic receptor function in dogs with heart failure. [PDF]
, 1988 Dorothy E. Vatner +6 more
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Gαq signalling from endosomes: A new conundrum
British Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley +1 more source