Results 141 to 150 of about 90,702 (257)

Deceptive beauty of non‐natural structures

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Structures of proteins and multiprotein complexes are considered landmark achievements. However, in many cases, mutant proteins are used for structural work. Even when wild type proteins are used, crystallization or complex formation for cryoEM is performed in highly nonphysiological conditions.
Vsevolod V. Gurevich, Eugenia V. Gurevich   +1 more
wiley   +1 more source

Stabilization versus flexibility: Detergent‐dependent trade‐offs in neurotensin receptor 1 GPCR ensembles

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Detergents provide essential membrane‐mimetic environments for studying G protein‐coupled receptors (GPCRs), but their molecular impact on receptor energetics remains incompletely understood. We combined ligand binding, thermostability measurements, and atomistic molecular dynamics to dissect detergent‐ versus ligand‐driven stabilization in a ...
James B. Bower, Wijnand J. C. van der Velden, Karen P. Gomez, Mingzhe Pan, Fabian Bumbak, Nagarajan Vaidehi, Joshua J. Ziarek   +6 more
wiley   +1 more source

Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor. [PDF]

Front Immunol, 2023
Costa SO, Chaves WF, Lopes PKF, Silva IM, Burguer B, Ignácio-Souza LM, Torsoni AS, Milanski M, Rodrigues HG, Desai M, Ross MG, Torsoni MA.   +11 more
europepmc   +1 more source

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. [PDF]

Elife, 2023
Vuckovic Z, Wang J, Pham V, Mobbs JI, Belousoff MJ, Bhattarai A, Burger WAC, Thompson G, Yeasmin M, Nawaratne V, Leach K, van der Westhuizen ET, Khajehali E, Liang YL, Glukhova A, Wootten D, Lindsley CW, Tobin A, Sexton P, Danev R, Valant C, Miao Y, Christopoulos A, Thal DM.   +23 more
europepmc   +1 more source

Six‐Year Trends in Real‐World Data Use for Post‐Marketing Surveillance of New Medical Products in Japan

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The Ministerial Ordinance on Good Post‐Marketing Study Practice for Drugs was amended by the Ministry of Health, Labour and Welfare (MHLW) in 2018 to clearly define post‐marketing database studies (DBS) as a measure of pharmacovigilance activities for approved medical products in Japan.
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia. [PDF]

Sci Rep, 2023
Cheng K, Chahdi A, Larabee SM, Tolaymat M, Sundel MH, Drachenberg CB, Zhan M, Hu S, Said AH, Shang AC, Xie G, Alizadeh M, Moura NS, Bafford AC, Williams RT, Hanna NN, Raufman JP.   +16 more
europepmc   +1 more source

Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati, Camille Rabesahala de Meritens, Miriam Stoeber, Vladimir L. Katanaev, Gonzalo P. Solis   +4 more
wiley   +1 more source

Muscarinic Receptor Stimulation Does Not Inhibit Voltage-dependent Ca²⁺ Channels in Rat Adrenal Medullary Chromaffin Cells. [PDF]

Acta Histochem Cytochem, 2023
Harada K, Inoue M.
europepmc   +1 more source

Muscarinic receptor M3 activation promotes fibrocytes contraction. [PDF]

Front Pharmacol, 2022
Henrot P, Eyraud E, Maurat E, Point S, Cardouat G, Quignard JF, Esteves P, Trian T, Girodet PO, Marthan R, Zysman M, Berger P, Dupin I.   +12 more
europepmc   +1 more source

M2 Muscarinic Receptor Stimulation Induces Autophagy in Human Glioblastoma Cancer Stem Cells via mTOR Complex-1 Inhibition. [PDF]

Cancers (Basel), 2023
Guerriero C, Manfredelli M, Matera C, Iuzzolino A, Conti L, Dallanoce C, De Amici M, Trisciuoglio D, Tata AM.   +8 more
europepmc   +1 more source