Results 141 to 150 of about 56,565 (298)

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Two-step structural changes in M3 muscarinic receptor activation rely on the coupled G_q protein cycle. [PDF]

Nat Commun, 2023
Kim YS, Yeon JH, Ko W, Suh BC.
europepmc   +1 more source

PRESYNAPTIC MUSCARINIC RECEPTORS INHIBITING ACTIVE ACETYLCHOLINE RELEASE IN THE BULLFROG SYMPATHETIC GANGLION [PDF]

, 1982
K. Koketsu, Masanobu Yamada
openalex   +1 more source

Risk of diabetes mellitus with olanzapine compared to clozapine: A systematic review and meta‐analysis

Psychiatry and Clinical Neurosciences Reports, Volume 4, Issue 4, December 2025.
Abstract Aim Olanzapine and clozapine are second‐generation antipsychotics commonly associated with metabolic side effects. In Japan, olanzapine is designated as “principally contraindicated” for patients with diabetes, while clozapine is “used with caution,” despite similar pharmacological profiles.
Keigo Onda, Rizal Ichwansyah, Shuken Boku   +2 more
wiley   +1 more source

Muscarinic receptor antagonists and airway inflammation: A systematic review on pharmacological models. [PDF]

Heliyon, 2022
Calzetta L, Pistocchini E, Ritondo BL, Cavalli F, Camardelli F, Rogliani P.   +5 more
europepmc   +1 more source

Fentanyl Disrupts Vagal Control of Airway Tone to Induce Transient Obstruction

Acta Physiologica, Volume 241, Issue 11, November 2025.
ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the primary cause of death in opioid overdose, resulting from both suppressed respiratory rhythm and increased airway and thoracic rigidity that compromise ventilation and resuscitation. While the effect(s) of opioids on central rhythm‐generating circuits are well documented, the mechanisms ...
Riley R. Parks, Marissa J. Andersen, Mackenna L. Hatfield, Nicholas J. Burgraff   +3 more
wiley   +1 more source

Astrocytes Reduce Store-Operated Ca²⁺ Entry in Microglia under the Conditions of an Inflammatory Stimulus and Muscarinic Receptor Blockade. [PDF]

Pharmaceuticals (Basel), 2022
Kim YJ, Shin YK, Seo E, Seol GH.
europepmc   +1 more source

Evidence that ionic channels associated with the muscarinic receptor of smooth muscle may admit calcium [PDF]

, 1983
T. B. Bolton, Kenji Kitamura
openalex   +1 more source

Structure–activity relationship of the allosteric effects of ivermectin at human P2X4 and GABAA receptors

British Journal of Pharmacology, Volume 182, Issue 21, Page 5286-5302, November 2025.
Abstract Background and purpose Positive allosteric modulation of the P2X4 receptor is a potential route to providing cardiovascular benefit through enhancing flow‐dependent arterial vasodilation and providing cardioprotection. However, ligands that selectively enhance P2X4 activity are absent.
Jessica L. Meades, Marcella Bassetto, Marius C. Staiculescu, Gayathri Swaminath, Samuel J. Fountain   +4 more
wiley   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways. [PDF]

Cells, 2023
Jude JA, Dainty I, Karmacharya N, Jester W, Panettieri R.   +4 more
europepmc   +1 more source