Results 151 to 160 of about 56,565 (298)

Muscarinic receptors coupled to phosphoinositide hydrolysis and elevated cytosolic calcium in a human neuroblastoma cell line SK‐N‐SH [PDF]

, 1989
John G. Baird, David G. Lambert, J. B. McBain, Stefan R. Nahorski   +3 more
openalex   +1 more source

Effect of N‐Butylscopolammonium Bromide and Metamizol Sodium on Heart Rate, Blood Pressure, and Echocardiographic Measurements in Warmblood Horses With Aortic and Mitral Valve Regurgitation

Journal of Veterinary Internal Medicine, Volume 39, Issue 6, November/December 2025.
ABSTRACT Background Administration of N‐butylscopolammonium bromide (NBB) with metamizol sodium (NBBM) causes tachycardia and hypertension, and has been associated with accentuated cardiac murmurs. Objectives To evaluate the effect of a pharmacological challenge using NBBM on valvular regurgitation and cardiac murmurs in horses with aortic (AR) and ...
Alexander Dufourni, Marie Demeyere, Ingrid Vernemmen, Glenn Van Steenkiste, Lize‐Maria Verhaeghe, Gunther van Loon, Annelies Decloedt   +6 more
wiley   +1 more source

Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans. [PDF]

Front Nucl Med, 2022
Cselényi Z, Jucaite A, Ewing P, Stenkrona P, Kristensson C, Johnström P, Schou M, Bolin M, Halldin C, Larsson B, Grime K, Eriksson UG, Farde L.   +12 more
europepmc   +1 more source

From Design to Outcome: The Role of Bi‐ and Multifunctional Ligands in Modern Therapeutics

Advanced Therapeutics, Volume 8, Issue 10, October 2025.
This review highlights the innovative use of bi‐ and multifunctional ligands for precision therapeutics. From strategic linker design to bioorthogonal conjugation and nanoscaffold integration, these approaches enable precise targeting, high‐resolution receptor mapping, and enhanced drug delivery.
Célia Bouacha, Séverine Denoyelle, Sonia Cantel   +2 more
wiley   +1 more source

(R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication. [PDF]

Neuropharmacology, 2023
Aracava Y, Albuquerque EX, Pereira EFR.
europepmc   +1 more source

THE HIGH AFFINITY CHOLINE UPTAKE SYSTEM WITH RESPECT TO THE MUSCARINIC RECEPTORS USING A SYNAPTOSOMAL FRACTION ABUNDANT IN PRESYNAPTIC MEMBRANES

, 1980
Yukio Takano, Yoshiro Kohjimoto, Hiro‐o Kamiya   +2 more
openalex   +1 more source

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source

From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials. [PDF]

Int J Neuropsychopharmacol
Meyer JM, Kramer K, Vuocolo S, Kaul I, Miller AC.   +4 more
europepmc   +1 more source

The M₁ muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. [PDF]

Proc Natl Acad Sci U S A, 2022
Marsango S, Jenkins L, Pediani JD, Bradley SJ, Ward RJ, Hesse S, Biener G, Stoneman MR, Tobin AB, Raicu V, Milligan G.   +10 more
europepmc   +1 more source

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

, 1989
Elizabeth A. Martinson, David Goldstein, Joan Heller Brown   +2 more
openalex   +1 more source