Results 151 to 160 of about 55,054 (301)

M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors. [PDF]

Function (Oxf), 2022
Alkawadri T, Wong PY, Fong Z, Lundy FT, McGarvey LP, Hollywood MA, Thornbury KD, Sergeant GP.   +7 more
europepmc   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl, Maria Majellaro, Alexey Bondar   +2 more
wiley   +1 more source

From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials. [PDF]

Int J Neuropsychopharmacol
Meyer JM, Kramer K, Vuocolo S, Kaul I, Miller AC.   +4 more
europepmc   +1 more source

Differential Actions of Muscarinic Receptor Subtypes in Gastric, Pancreatic, and Colon Cancer. [PDF]

Int J Mol Sci, 2021
Schledwitz A, Sundel MH, Alizadeh M, Hu S, Xie G, Raufman JP.   +5 more
europepmc   +1 more source

THE HIGH AFFINITY CHOLINE UPTAKE SYSTEM WITH RESPECT TO THE MUSCARINIC RECEPTORS USING A SYNAPTOSOMAL FRACTION ABUNDANT IN PRESYNAPTIC MEMBRANES

, 1980
Yukio Takano, Yoshiro Kohjimoto, Hiro‐o Kamiya   +2 more
openalex   +1 more source

Characterization of the muscarinic receptor subtype mediating contractions of the guinea‐pig uterus [PDF]

, 1989
Richard M. Eglen, A.D. Michel, R.L. Whiting   +2 more
openalex   +1 more source

Arrestin‐centred interactions at the membrane and their conformational determinants

British Journal of Pharmacology, Volume 182, Issue 14, Page 3135-3150, July 2025.
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood, Raphael Silvanus Haider, Julie Sanchez, Meritxell Canals   +3 more
wiley   +1 more source

Discovering Key Activation Hotspots in the M₂ Muscarinic Receptor. [PDF]

J Am Chem Soc
Sugiura Y, Ikuta T, Sumii Y, Tsujimoto H, Suzuki K, Suno R, Ariff PNABM, Iwata S, Shibata N, Inoue A, Kobayashi T, Kandori H, Katayama K.   +12 more
europepmc   +1 more source

Blocking Muscarinic Receptor 3 Attenuates Tumor Growth and Decreases Immunosuppressive and Cholinergic Markers in an Orthotopic Mouse Model of Colorectal Cancer. [PDF]

Int J Mol Sci, 2022
Kuol N, Davidson M, Karakkat J, Filippone RT, Veale M, Luwor R, Fraser S, Apostolopoulos V, Nurgali K.   +8 more
europepmc   +1 more source

Presynaptic muscarinic receptors mediating inhibition of neurogenic contractions in rabbit vas deferens are of the ganglionic M1-type [PDF]

, 1988
Manfrid Eltze, G. Gmelin, Jürgen Wess, Carsten Strohmann, Reinhold Tacke, E. Mutschler, Günter Lambrecht   +6 more
openalex   +1 more source