Results 161 to 170 of about 90,702 (257)

From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials. [PDF]

Int J Neuropsychopharmacol
Meyer JM, Kramer K, Vuocolo S, Kaul I, Miller AC.   +4 more
europepmc   +1 more source

Two-step structural changes in M3 muscarinic receptor activation rely on the coupled G_q protein cycle. [PDF]

Nat Commun, 2023
Kim YS, Yeon JH, Ko W, Suh BC.
europepmc   +1 more source

Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn reduce NPY levels via muscarinic receptor activation. [PDF]

Cardiovasc Res
Jani NR, van Weperen VYH, Ayagama T, Hoang JD, Emamimeybodi M, Bussmann BM, Bal S, Kumar A, Khaky A, Hamon D, Herring N, Smith C, Vaseghi M.   +12 more
europepmc   +1 more source

Astrocytes Reduce Store-Operated Ca²⁺ Entry in Microglia under the Conditions of an Inflammatory Stimulus and Muscarinic Receptor Blockade. [PDF]

Pharmaceuticals (Basel), 2022
Kim YJ, Shin YK, Seo E, Seol GH.
europepmc   +1 more source

Selective modulation of murine intestinal M₁ and M₃ muscarinic receptor expression has divergent effects on specialized epithelial cells and body weight. [PDF]

Am J Physiol Cell Physiol
Sampaio Moura N, Schledwitz A, Cheng K, Song Y, Kwon MS, Cairns CA, Njei LP, Raufman B, Drachenberg CB, Wang JY, Ma B, Raufman JP.   +11 more
europepmc   +1 more source

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β₂ Adrenergic Receptor Agonist Navafenterol in Human Small Airways. [PDF]

Cells, 2023
Jude JA, Dainty I, Karmacharya N, Jester W, Panettieri R.   +4 more
europepmc   +1 more source

Muscarinic Receptor Antagonism and TRPM3 Activation as Stimulators of Mitochondrial Function and Axonal Repair in Diabetic Sensorimotor Polyneuropathy. [PDF]

Int J Mol Sci
Chauhan S, Calcutt NA, Fernyhough P.
europepmc   +1 more source

Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans. [PDF]

Front Nucl Med, 2022
Cselényi Z, Jucaite A, Ewing P, Stenkrona P, Kristensson C, Johnström P, Schou M, Bolin M, Halldin C, Larsson B, Grime K, Eriksson UG, Farde L.   +12 more
europepmc   +1 more source

Discovering Key Activation Hotspots in the M₂ Muscarinic Receptor. [PDF]

J Am Chem Soc
Sugiura Y, Ikuta T, Sumii Y, Tsujimoto H, Suzuki K, Suno R, Ariff PNABM, Iwata S, Shibata N, Inoue A, Kobayashi T, Kandori H, Katayama K.   +12 more
europepmc   +1 more source

The M₁ muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. [PDF]

Proc Natl Acad Sci U S A, 2022
Marsango S, Jenkins L, Pediani JD, Bradley SJ, Ward RJ, Hesse S, Biener G, Stoneman MR, Tobin AB, Raicu V, Milligan G.   +10 more
europepmc   +1 more source