Results 161 to 170 of about 55,054 (301)

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, Volume 182, Issue 14, Page 3151-3162, July 2025.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Manipulation of Chemistry and Biology with Visible Light Using Tetra‐ortho‐Substituted Azobenzenes and Azonium Ions

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
Tetra‐ortho‐Azobenzenes (TOABs) in broad daylight: in recent years, TOAB photoswitches became indispensable tools for all‐visible‐light manipulation of chemistry, biology and materials. This review explores their unique photochemical properties, design and synthetic approaches, offering support in choosing a TOAB for a given application.
Francesca Cardano, Rosa Márquez García, Wiktor Szymanski   +2 more
wiley   +2 more sources

IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia

Pharmacological Research
Cobenfy, a co-formulation of xanomeline and trospium, is the first drug not acting on the dopaminergic system of the CNS approved for the treatment of schizophrenia by the FDA.
Brian Dean
doaj  

Developing muscarinic receptor M1 classification models utilizing transfer learning and generative AI techniques. [PDF]

Sci Rep
Dey S, Wallqvist A, AbdulHameed MDM.
europepmc   +1 more source

M₁ muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease. [PDF]

Sci Signal, 2022
Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn J, Lindsley CW, Bradley SJ, Tobin AB.   +13 more
europepmc   +1 more source

Muscarinic Receptor Activation of Phosphatidylcholine Hydrolysis

, 1989
Elizabeth A. Martinson, David Goldstein, Joan Heller Brown   +2 more
openalex   +1 more source

Quantitative in vivo receptor binding. I. Theory and application to the muscarinic cholinergic receptor [PDF]

, 1985
K.A. Frey, RL Ehrenkaufer, Serge L. Beaucage, BW Agranoff   +3 more
openalex   +1 more source

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

Angewandte Chemie, Volume 137, Issue 24, June 10, 2025.
A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth, Eduard Neu, Davide Provasi, Steffen Feustel, Maximilian F. Schmidt, Harald Hübner, Dorothée Weikert, Marta Filizola, Burkhard König, Peter Gmeiner   +9 more
wiley   +2 more sources

Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury. [PDF]

J Crohns Colitis
Ragab M, Wieland J, Waldherr Avila de Melo C, Agibalova T, Ermolova A, Durner N, Hempel A, Heindl F, Maurer HC, Steiger K, Janssen KP, Tschurtschenthaler M, Wang TC, Quante M, Schmid RM, Middelhoff M.   +15 more
europepmc   +1 more source