Results 161 to 170 of about 2,368,108 (305)

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential

, 2012
Anette Sams, Krestian Larsen, Gitte Kobberøe Mikkelsen, Morten Hentzer, Claus T. Christoffersen, Klaus Gjervig Jensen, Kristen Frederiksen, Benny Bang‐Andersen   +7 more
openalex   +1 more source

Edible Seeds in the Fight Against Hypertension: A Review of In Vitro, In Vivo, and Clinical Evidences With a Mechanistic Insight of Bioactive Compounds

Food Frontiers, Volume 7, Issue 1, January 2026.
The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi, Mohamad Fawzi Mahomoodally, Ahmed Abduljalal Abduljabbar, Ruttun Bushra Umme Zainab, Katharigatta N. Venugopala, Gokhan Zengin, Sakina Yagi, Meng‐Yao Li, Xuebo Hu   +8 more
wiley   +1 more source

Muscarinic Receptor-Mediated Electroacupuncture Modulation of Reactive Enteric Glial Cells Ameliorates Postoperative Ileus. [PDF]

J Inflamm Res
He J, Huang R, Ouyang J, Zhao G, Zhong M.   +4 more
europepmc   +1 more source

Muscarinic receptor regulation of chronic pain-induced atrial fibrillation. [PDF]

Front Cardiovasc Med, 2022
Gong C, Ding Y, Liang F, Wu S, Tang X, Ding H, Huang W, Yu X, Zhou L, Li J, Liu S.   +10 more
europepmc   +1 more source

Bile Acid-Induced Arrhythmia Is Mediated by Muscarinic M2 Receptors in Neonatal Rat Cardiomyocytes

, 2010
Siti Hamimah Sheikh Abdul Kadir, Michele Miragoli, Shadi Abu‐Hayyeh, Alexey Moshkov, Qilian Xie, Verena Keitel, Viacheslav O. Nikolaev, Catherine Williamson, Julia Gorelik   +8 more
openalex   +2 more sources

Muscarinic receptors participation in angiogenic response induced by macrophages from mammary adenocarcinoma-bearing mice [PDF]

, 2005
Eulalia de la Torre, L Davel, María A. Jasnis, Tomomi Gotoh, Eugenia Sacerdote de Lustig, Marı́a Elena Sales   +5 more
openalex   +1 more source

From Synaptic Plasticity and Critical Periods to Social Behavior and Stress: Getting to, and Staying in, CA2

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT Hippocampal Area CA2, with some exceptions, had long been neglected in in vivo studies, due largely to its small size, and in in vitro studies because of its general similarity to CA3 and CA1. Increasing evidence showing that CA2 was molecularly distinct led to the increased appreciation of CA2 as a separate region, and as such, that it likely
Serena M. Dudek
wiley   +1 more source

Clinical Effectiveness of Muscarinic Receptor-Targeted Interventions in Neuropsychiatric Disorders: A Systematic Review. [PDF]

CNS Drugs, 2022
Vaidya S, Guerin AA, Walker LC, Lawrence AJ.   +3 more
europepmc   +1 more source

Nerve‐evoked purinergic signalling suppresses action potentials, Ca²⁺ flashes and contractility evoked by muscarinic receptor activation in mouse urinary bladder smooth muscle [PDF]

, 2009
Thomas J. Heppner, Matthias Werner, Bernhard Nausch, Catherine Vial, Richard J. Evans, Mark T. Nelson   +5 more
openalex   +1 more source

Spirocyclic Diamine Scaffolds for Medicinal Chemistry

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
Here we enumerated 391 spirocyclic diamine drug scaffolds with ring sizes four to eight and found that most of them are unknown. We prepared four novel such spirocycles and discovered a micromolar inhibitor of the M4 muscarinic receptor. ABSTRACT Medicinal chemistry requires the exploration of structurally diverse compound families to expand the ...
Aline Carrel, Alejandro Flores, Maedeh Darsaraee, Jean‐Louis Reymond   +3 more
wiley   +1 more source