Results 201 to 210 of about 90,702 (257)
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Muscarinic Acetylcholine Receptors
Current Pharmaceutical Design, 2006Muscarinic acetylcholine receptors mediate diverse physiological functions. At present, five receptor subtypes (M(1) - M(5)) have been identified. The odd-numbered receptors (M(1), M(3), and M(5)) are preferentially coupled to G(q/11) and activate phospholipase C, which initiates the phosphatidylinositol trisphosphate cascade leading to intracellular ...
Masaru, Ishii, Yoshihisa, Kurachi
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Muscarinic Receptor Trafficking
2011Knowledge of the mechanisms responsible for the trafficking of neurotransmitter receptors away from the cell surface is of obvious importance in understanding what regulates their expression and function. This chapter will focus on the mechanisms responsible for the internalization and degradation of muscarinic receptors.
Cindy, Reiner, Neil M, Nathanson
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Muscarinic Receptor Antagonists
2016Parasympathetic activity is increased in patients with chronic obstructive pulmonary disease (COPD) and asthma and appears to be the major reversible component of airway obstruction. Therefore, treatment with muscarinic receptor antagonists is an effective bronchodilator therapy in COPD and also in asthmatic patients.
Maria Gabriella, Matera, Mario, Cazzola
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Constitutively active muscarinic receptors
Life Sciences, 2001Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
T A, Spalding, E S, Burstein
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Desensitization of Muscarinic Receptors
Receptors and Channels, 2004When Chinese hamster ovary cells transfected with the gene for M(3)-muscarinic receptors were stimulated with carbachol continuously for 30 min, the response at the end of the stimulation period was about 20% of the early response (2-3 min after the start of the stimulation).
N, Fraeyman +3 more
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Muscarinic Receptors in Schizophrenia
Current Molecular Medicine, 2003An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have shown there are regionally specific decreases in selective muscarinic receptors in the CNS of subjects ...
B, Dean, F P, Bymaster, E, Scarr
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Muscarinic receptors in pineal
Life Sciences, 1980Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
R L, Taylor, M L, Albuquerque, D R, Burt
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Presynaptic muscarinic cholinergic receptors
Nature, 1978IN the isolated rabbit heart, acetylcholine inhibits the release of noradrenaline evoked by nicotinic drugs1, by KCl (ref. 2) and by sympathetic nerve stimulation3. The release of noradrenaline in response to sympathetic nerve stimulation in the rabbit heart was found to be reduced by para-sympathomimetic agonists, and atropine antagonised this effect ...
V K, Sharma, S P, Banerjee
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Current Protocols in Pharmacology, 1999
AbstractIn the central and peripheral nervous systems, the actions of acetylcholine are mediated by families of ligand gated ion channels and metabotropic receptors. The latter family is composed of muscarinic receptors, since they are selectively activated by muscarine and antagonized by atropine. Five muscarinic receptor subtypes have been identified
Richard M. Eglen +3 more
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AbstractIn the central and peripheral nervous systems, the actions of acetylcholine are mediated by families of ligand gated ion channels and metabotropic receptors. The latter family is composed of muscarinic receptors, since they are selectively activated by muscarine and antagonized by atropine. Five muscarinic receptor subtypes have been identified
Richard M. Eglen +3 more
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2002
Abstract The pharmacology of acetylcholine is in many ways a very old subject. The use of antimuscarinic plant extracts as both poisons and therapies can be traced back to ancient times. Thus, Linnaeus gave the systematic name Atropa belladonna to the deadly nightshade, in homage to Atropos of Greek mythology, who cuts the thread of life,
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Abstract The pharmacology of acetylcholine is in many ways a very old subject. The use of antimuscarinic plant extracts as both poisons and therapies can be traced back to ancient times. Thus, Linnaeus gave the systematic name Atropa belladonna to the deadly nightshade, in homage to Atropos of Greek mythology, who cuts the thread of life,
openaire +1 more source