Results 261 to 270 of about 56,565 (298)

Muscarinic Acetylcholine Receptors

1988
The central and peripheral actions of the endogenous neurotransmitter acetylcholine (ACh) are exerted at two main types of receptor, present in both the central and peripheral nervous system of all mammals. Their definition and pharmacological classification dates back to the work of Sir Henry Dale (1914), who demonstrated that certain actions of ACh ...
J. Järv, Tamas Bartfai
openaire   +2 more sources

Constitutively active muscarinic receptors

Life Sciences, 2001
Mutations that increase constitutive activity and alter ligand binding have been used to investigate the structure and mechanism of activation of muscarinic receptors. These data are reviewed with reference to the recently published three-dimensional structure of rhodopsin.
Ethan S. Burstein, Tracy A. Spalding
openaire   +2 more sources

Muscarinic receptors revisited

Trends in Neurosciences, 1983
Abstract It is now thought that muscarinic acetylcholine receptors are not identical, and the evidence for this is reviewed briefly, with emphasis on functional studies. In the brain, there is evidence that different subtypes of muscarinic receptors are localized in different regions and there are early suggestions that these may have distinct ...
Malcolm Caulfield, Donald W. Straughan
openaire   +2 more sources

Muscarinic receptors in the Mammalian Heart

Pharmacological Research, 2001
In the mammalian heart, cardiac function is under the control of the sympathetic and parasympathetic nervous system. All regions of the mammalian heart are innervated by parasympathetic (vagal) nerves, although the supraventricular tissues are more densely innervated than the ventricles.
Chris J. van Koppen, Stefan Dhein, Otto-Erich Brodde   +2 more
openaire   +3 more sources

CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment

This review explores the main aspects that form the basis of the cholinergic-oriented treatment of Alzheimer disease. Muscarinic acetylcholine receptor subtypes in the brain and periphery are discussed. It includes a new and updated overview of the involvement of muscarinic receptors in Alzheimer disease and the recent development of new and highly ...
Abraham, Fisher, Allan I, Levey
openaire   +2 more sources

Muscarinic receptors in human airways

Journal of Allergy and Clinical Immunology, 1995
Muscarinic receptors play a double role in airway disorders, mediating an increase in mucus secretion, as well as constriction of smooth muscle. Cholinergic activity of the lung is more pronounced in large than in peripheral airways; in the nose parasympathetic stimulation leads to hypersecretion and vasodilation.
openaire   +3 more sources

Muscarinic Receptors

Nature, 1961
A H, BECKETT, N J, HARPER, J W, CLITHEROW, E, LESSER   +3 more
openaire   +2 more sources

Muscarinic Receptor Antagonists

Pulmonary Pharmacology & Therapeutics, 1999
N. Watson, R.M. Eglen
openaire   +3 more sources

Systemic therapy for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative early stage and metastatic breast cancer

Ca-A Cancer Journal for Clinicians, 2023
Laura A Huppert, Hope S Rugo
exaly  

Critical care management of chimeric antigen receptor T‐cell therapy recipients

Ca-A Cancer Journal for Clinicians, 2022
Alexander Shimabukuro-Vornhagen, Boris Böll, Victoria Metaxa   +2 more
exaly