Results 261 to 270 of about 2,365,631 (384)

Gαq signalling from endosomes: A new conundrum

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3068-3089, July 2025.
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

The activation of M 3 muscarinic receptor reverses liver injuryvia the Sp1/lncRNA Gm2199/miR-212 axis. [PDF]

open access: yesActa Biochim Biophys Sin (Shanghai), 2022
Zhang H   +9 more
europepmc   +1 more source

Microscopy and spectroscopy approaches to study GPCR structure and function

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.
Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl   +2 more
wiley   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

open access: yesPharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova   +2 more
doaj  

Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. [PDF]

open access: yesProc Natl Acad Sci U S A, 2021
Scarpa M   +14 more
europepmc   +1 more source

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