Results 71 to 80 of about 1,290,722 (202)

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Expression of Non-neuronal Acetylcholine in Lung Cancer Provides a New Target for Cancer

Journal of Pharmacological Sciences, 2008
Lung cancer is the leading cause of cancer death worldwide and new treatment strategies are clearly needed. The recent discovery that lung and other cancers synthesize and secrete acetylcholine (ACh) which acts as an autocrine growth factor suggests that
Therapy Pingfang Song, Eliot R. Spindel
doaj   +1 more source

The molecular basis of V2 vasopressin receptor-G Protein coupling selectivity [PDF]

, 2003
G­Protein­gekoppelte Rezeptoren (GPCRs) stellen eine der größten in der Natur vorkommenden Proteinfamilien dar (Watson and Arkinstall, 1994). GPCRs sind plasmamembranständige Proteine, die mit heterotrimären G­Proteinen interagieren und eine Vielzahl an ...
Erlenbach, Isolde
core  

Pharmacological investigations on muscarinic and P2 receptor subtypes : pharmacological charakterisation of the stereoisomers of glycopyrronium bromide and their tertiary analogues and evaluation of the isolated guinea-pig and rat ileal longitudinal [PDF]

, 2003
Die Beschäftigung mit Muskarinrezeptoren reicht bis in das vergangene Jahrhundert zurück als, in Folge der verschiedenen Wirkungen des Neurotransmitters Acetylcholin, einerseits Nikotin- und andererseits Muskarinrezeptoren sowie deren Subtypen entdeckt ...
Czeche, Sittah
core  

Autoradiography of 3H-pirenzepine and 3H-AFDX-384 in Mouse Brain Regions: Possible Insights into M1, M2, and M4 Muscarinic Receptors Distribution

Frontiers in Pharmacology, 2018
Autoradiography helps to determine the distribution and density of muscarinic receptor (MR) binding sites in the brain. However, it relies on the selectivity of radioligands toward their target.
Paulina Valuskova, Vladimir Farar, Sandor Forczek, Iva Krizova, Jaromir Myslivecek   +4 more
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Radioprotective effect of lidocaine on neurotransmitter agonist-induced secretion in irradiated salivary glands. [PDF]

, 2013
Previously we verified the radioprotective effect of lidocaine on the function and ultrastructure of salivary glands in rabbits. However, the underlying mechanism of lidocaine's radioprotective effect is unknown.
Klinger, Matthias, Yu-xiong Su, Dirk Rades, Sieg, Peter, Liao, Guiqing, Dendorfer, Andreas, Liao, Gui-qing, Hakim, Samer G., Benedek, Geza Attila, Klinger, Matthias Heinrich Friedrich, Gui-qing Liao, Andreas Dendorfer, Peter Sieg, Birgit Meller, Hakim, Samer George, Samer G Hakim, Benedek, Geza A., Su, Yuxiong, Rades, Dirk, Geza A Benedek, Matthias Klinger, Su, Yu-xiong, Meller, Birgit   +22 more
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Role of K+ Channels in M2 Muscarinic Receptor-Mediated Inhibition of Noradrenaline Release From the Rat Stomach

Journal of Pharmacological Sciences, 2004
Previously we reported the cholinergic M2 muscarinic receptor-mediated inhibition of noradrenaline release from the rat stomach (K. Yokotani, Y. Osumi. J Pharmacol Exp Ther. 1993;264:54–60).
Kumiko Nakamura, Shoshiro Okada, Naoko Yamaguchi, Takahiro Shimizu, Keiko Yokotani, Kunihiko Yokotani   +5 more
doaj   +1 more source

Phospholipase C Involvement in Activation of the Muscarinic Receptor-Operated Cationic Current in Guinea Pig Ileal Smooth Muscle Cells

Journal of Pharmacological Sciences, 2004
In guinea pig single ileal smooth muscle cells held under voltage-clamp, the role of phospholipase C (PLC) in activation of the muscarinic receptor-operated cationic current (Icat) was studied. U73122, a PLC inhibitor, prevented the generation of Icat by
Hiroyuki Okamoto, Toshihiro Unno, Daisuke Arima, Maki Suzuki, Hai-Dun Yan, Hayato Matsuyama, Masakazu Nishimura, Seiichi Komori   +7 more
doaj   +1 more source

Polymorphisms in human muscarinic receptor subtype genes

, 2011
A wide range of polymorphisms have been reported in muscarinic receptor subtype genes, mostly in M₁ and M₂ and, to a lesser extent, M₃ receptors. Most studies linking such genetic variability to phenotype have been performed for brain functions, but a ...
Christine A. Teitsma, Teitsma, Christine A., Michel, Martin C., Martin C. Michel   +3 more
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Case report : Acute unintentional carbachol intoxication [PDF]

, 2006
Introduction: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning.
Schulz, Martin, Stuby, Klaus, Andresen, Hilke, Kupfermann, Nikolai, Schmoldt, Achim, Graefe, Thomas   +5 more
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The Forefront for Novel Therapeutic Agents Based on the Pathophysiology of Lower Urinary Tract Dysfunction: Bladder Selectivity Based on In Vivo Drug–Receptor Binding Characteristics of Antimuscarinic Agents for Treatment of Overactive Bladder

Journal of Pharmacological Sciences, 2010
We have reviewed the binding of antimuscarinic agents, used to treat urinary dysfunction in patients with overactive bladder, to muscarinic receptors in target and non-target tissues in vivo.
Akira Yoshida, Tomomi Fujino, Shuji Maruyama, Yoshihiko Ito, Yuko Taki, Shizuo Yamada   +5 more
doaj   +1 more source