Results 81 to 90 of about 1,290,722 (202)

P2Y₂ Nucleotide Receptors Expressed Heterologously in Sympathetic Neurons Inhibit Both N-Type Ca²⁺ and M-Type K⁺ Currents [PDF]

, 1998
The P2Y₂ receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway.
Webb, TE, Brown, DA, Barnard, EA, Filippov, AK   +3 more
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The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice

Scientific Reports, 2019
Muscarinic acetylcholine receptors have been implicated as potential neuroprotective targets for glaucoma. We tested the hypothesis that the lack of a single muscarinic receptor subtype leads to age-dependent neuron reduction in the retinal ganglion cell
Panagiotis Laspas, Mayagozel B. Zhutdieva, Christoph Brochhausen, Aytan Musayeva, Jenia Kouchek Zadeh, Norbert Pfeiffer, Ning Xia, Huige Li, Juergen Wess, Adrian Gericke   +9 more
doaj   +1 more source

The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner

, 2010
Degeneration of the cholinergic system is considered to be the underlying pathology that results in the cognitive deficit in Alzheimer's disease. This pathology is thought to be linked to a loss of signaling through the cholinergic M1-muscarinic receptor
Pawlak, Robert, Poulin, B., Rosethorne, E. M., K. C. Kong, A. Butcher, Tobin, Andrew B., Kong, K. C., Pawlak, R., P. McWilliams, McWilliams, Phillip, S. J. Charlton, Butcher, Adrian J., McWilliams, P., Mistry, Sharad, Charlton, Steven J., E. M. Rosethorne, J.-M. Bourgognon, Charlton, Steven, Bottrill, A., Wess, J., Rosethorne, Elizabeth M., Tobin, A. B., Bottrill, Andrew, A. B. Tobin, A. Bottrill, Butcher, A., R. Pawlak, Poulin, Benoit, J. Wess, Charlton, S. J., Butcher, Adrian, Tobin, Andrew, Bottrill, Andrew R., Bourgognon, Julie-Myrtille, B. Poulin, S. Mistry, Wess, Jürgen, Mistry, S., Kong, Kok Choi, Rosethorne, Liz   +39 more
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Critical role of the cholinergic system for object-in-place associative recognition memory [PDF]

, 2009
Object-in-place memory, which relies on the formation of associations between an object and the place in which it was encountered, depends upon a neural circuit comprising the perirhinal (PRH) and medial prefrontal (mPFC) cortices.
Warburton, Elizabeth C, Barker, GRI
core   +1 more source

IUPHAR Review on muscarinic M1 and M4 receptors as drug treatment targets relevant to the molecular pathology of schizophrenia

Pharmacological Research
Cobenfy, a co-formulation of xanomeline and trospium, is the first drug not acting on the dopaminergic system of the CNS approved for the treatment of schizophrenia by the FDA.
Brian Dean
doaj   +1 more source

Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons [PDF]

, 2006
Basal forebrain (BF) neurons provide the principal cholinergic drive to the hippocampus and cortex. Their degeneration is associated with the cognitive defects of Alzheimer's disease. Immunohistochemical studies suggest that some of these neurons contain
Allen, TGJ, Abogadie, FC, Brown, DA
core  

Muscarinic Receptor Signaling in Colon Cancer

, 2011
According to the adenoma-carcinoma sequence, colon cancer results from accumulating somatic gene mutations; environmental growth factors accelerate and augment this process.
Jean-Pierre Raufman, Erik C. Von Rosenvinge   +1 more
core   +1 more source

Expression of muscarinic receptor subtypes and M2-muscarinic inhibition of adenylyl cyclase in lung

, 1995
The relative distribution and absolute quantities of muscarinic receptor subtypes m1, m2, m3, and m4 were determined in membranes of canine trachealis muscle, bronchi, and lung parenchyma by immuno-precipitation with receptor subtype-specific rabbit ...
C. W. Emala, A. Aryana, B. B. Wolfe, R. P. Yasuda, C. A. Hirshman, S. A. Satkus, M. A. Levine   +6 more
core   +1 more source

Molecular dynamics simulations of the muscarinic receptor [PDF]

, 2015
Title: Molecular dynamics simulations of the muscarinic receptor Author: Radim Cajzl Department: Institute of Physics of Charles University Supervisor: RNDr.
Cajzl, Radim
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Antimuscarinic drugs exert β-arrestin-biased agonism at the muscarinic acetylcholine type 1 receptor

The M1 muscarinic acetylcholine receptor (M1R) is highly expressed in the nervous system, and has been studied to discover new therapeutic drugs for a range of neurological and psychiatric disorders.
Amiri, Shayan
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