Results 1 to 10 of about 2,392,791 (334)

A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia [PDF]

Frontiers in Cellular Neuroscience, 2023
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic receptors in the molecular pathology of schizophrenia. From these data it was proposed that activation of the muscarinic M1 and/or M4 receptor would reduce the ...
Brian Dean, Geor Bakker, Hiroki R. Ueda, Hiroki R. Ueda, Andrew B. Tobin, Alastair Brown, Richard A. A. Kanaan   +6 more
doaj   +2 more sources

Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors [PDF]

Frontiers in Neural Circuits, 2021
Neuromodulation by acetylcholine plays a vital role in shaping the physiology and functions of cerebral cortex. Cholinergic neuromodulation influences brain-state transitions, controls the gating of cortical sensory stimulus responses, and has been shown
Susheel Vijayraghavan, Stefan Everling, Stefan Everling   +2 more
doaj   +2 more sources

Agonist-selective activation of individual G-proteins by muscarinic receptors [PDF]

Scientific Reports
Selective activation of individual subtypes of muscarinic receptors is a promising way to safely alleviate a wide range of pathological conditions in the central nervous system and the periphery as well.
Dominik Nelic, Nikolai Chetverikov, Martina Hochmalová, Christina Diaz, Vladimír Doležal, John Boulos, Jan Jakubík, Kirill Martemyanov, Alena Janoušková-Randáková   +8 more
doaj   +2 more sources

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +3 more sources

Characterization of Bladder Selectivity of Antimuscarinic Agents on the Basis of Drug-Receptor Binding [PDF]

International Neurourology Journal, 2012
The in vivo muscarinic receptor binding of antimuscarinic agents (oxybutynin, solifenacin, tolterodine, and imidafenacin) used to treat urinary dysfunction in patients with overactive bladder is reviewed.
Shizuo Yamada, Shiori Kuraoka, Ayaka Osano, Yoshihiko Ito   +3 more
doaj   +1 more source

Antipsychotic-like effect of the muscarinic acetylcholine receptor agonist BuTAC in non-human primates. [PDF]

PLoS ONE, 2015
Cholinergic, muscarinic receptor agonists exhibit functional dopamine antagonism and muscarinic receptors have been suggested as possible future targets for the treatment of schizophrenia and drug abuse. The muscarinic ligand (5R,6R)-6-(3-butylthio-1,2,5-
Maibritt B Andersen, Carrie Hughes Croy, Ditte Dencker, Thomas Werge, Frank P Bymaster, Christian C Felder, Anders Fink-Jensen   +6 more
doaj   +1 more source

The metronomic combination of paclitaxel with cholinergic agonists inhibits triple negative breast tumor progression. Participation of M2 receptor subtype

PLoS ONE, 2020
Triple negative tumors are more aggressive than other breast cancer subtypes and there is a lack of specific therapeutic targets on them. Since muscarinic receptors have been linked to tumor progression, we investigated the effect of metronomic therapy ...
Alejandro J. Español, Agustina Salem, María Di Bari, Ilaria Cristofaro, Yamila Sanchez, Ada M. Tata, María E. Sales, Irina V. Lebedeva   +7 more
doaj   +2 more sources

Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers [PDF]

, 2015
Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be
Alvarez-Curto, Elisa, Aslanoglou, Despoina, Marsango, Sara, Milligan, Graeme   +3 more
core   +1 more source

Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration

Journal of Pharmacological Sciences, 2019
The present study aimed to characterize muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine (5-HMT), and tolterodine in bladder and other tissues of rats after their oral, intravenous, or intravesical administration.
Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Yoshihisa Kato, Satomi Onoue   +4 more
doaj   +1 more source

Direct in vitro and in vivo demonstration of muscarinic receptor binding by the novel radioligand, [3H]5-hydroxymethyltolterodine, in the bladder and other tissues of rats

Journal of Pharmacological Sciences, 2020
In vitro and in vivo binding sites of [3H]-labeled 5-hydroxymethyltolterodine (5-HMT), a new radioligand for labeling muscarinic receptors in rat tissues were characterized.
Shizuo Yamada, Shiori Kuraoka, Yoshihiko Ito, Satomi Kagota, Kazumasa Shinozuka, Satomi Onoue   +5 more
doaj   +1 more source