Results 221 to 230 of about 52,654 (280)

Muscarinic receptors mediate motivation via preparatory neural activity in humans

, 2021
Grogan JP, Raemaekers M, Van Swieten MMH, Green AL, Gillies MJ, Manohar SG.   +5 more
europepmc   +1 more source

Selectivity of bethanechol on muscarinic receptors

Journal of Pharmacy and Pharmacology, 1978
openaire   +2 more sources

Muscarinic receptors and drugs in cardiovascular medicine

Cardiovascular Drugs and Therapy, 1995
The parasympathetic system and its associated muscarinic receptors have been the subject of a renaissance of interest for the following two main reasons: (1) the association of endothelial muscarinic receptors and the nitric oxide (NO) pathway; (2) the ...
H N Doods
exaly   +2 more sources

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Muscarinic Receptor Subtypes

Annual Review of Pharmacology and Toxicology, 1990
In 1914, Sir Henry Dale provided the basis for the classical and comfortable definition of muscarinic and nicotinic acetylcholine receptors: Muscarinic receptors are selectively activated by muscarine and blocked by atropine; nicotinic receptors are activated by nicotine and blocked by curare.
E C, Hulme, N J, Birdsall, N J, Buckley
openaire   +2 more sources

Desensitization of Muscarinic Receptors

Receptors and Channels, 2004
When Chinese hamster ovary cells transfected with the gene for M(3)-muscarinic receptors were stimulated with carbachol continuously for 30 min, the response at the end of the stimulation period was about 20% of the early response (2-3 min after the start of the stimulation).
N, Fraeyman, J, van Emmelo, R H, Paulssen, K, Vermis   +3 more
openaire   +2 more sources

Muscarinic Receptors in Schizophrenia

Current Molecular Medicine, 2003
An increasing body of evidence suggests that the muscarinic receptors may present a potential therapeutic target for the treatment of schizophrenia. This argument is supported by studies using postmortem CNS tissue and a neuroimaging study that have shown there are regionally specific decreases in selective muscarinic receptors in the CNS of subjects ...
B, Dean, F P, Bymaster, E, Scarr
openaire   +2 more sources

Calcium and the muscarinic receptor

General Pharmacology: The Vascular System, 1976
Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response.
M K, Ticku, D J, Triggle
openaire   +2 more sources

Muscarinic receptors in pineal

Life Sciences, 1980
Abstract The presence of muscarinic receptors in sheep and rat pineals was detected by binding of [ 3 H]quinuclidinyl benzilate ([ 3 H]QNB), a potent and specific muscarinic antagonist. [ 3 H]QNB binding to sheep pineal membrane resuspensions was saturable and reversible, with a rate constant for association at 37°C of 6×10 8 M −1 min −1 and a rate ...
R L, Taylor, M L, Albuquerque, D R, Burt
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MUSCARINIC RECEPTOR DIFFERENTIATION

Clinical and Experimental Pharmacology and Physiology, 1989
SUMMARY1. Several selective antagonists are available to differentiate between muscarinic receptors.2. Further subdivision of M1 and M2 muscarinic receptors appears possible and is supported by studies with cloned receptors.3. Reasons for differences between affinity constants determined in functional and binding studies and whether receptor subtypes ...
F, Mitchelson, L K, Choo, S, Darroch
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Muscarinic acetylcholine receptor

Progress in Neurobiology, 1978
ABSTRACT Muscarinic acetylcholine receptors from rat cerebral cortex and small intestine were studied by the high affinity and high specific activity antagonists 3 H-3-quinuclidinyl benzilate (3-QNB) (29.4 Ci/mmol) and 3 H-N-methyl-4-piperidinyl benzilate (4-NMPB) (55.4 Ci/mmol).
E, Heilbronn, T, Bartfai
openaire   +2 more sources