Results 1 to 10 of about 3,179,601 (345)

Vascular smooth muscle contraction in hypertension [PDF]

Cardiovascular Research, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +2 more sources

Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching. [PDF]

PLoS ONE, 2012
Bindarit, a selective inhibitor of monocyte chemotactic proteins (MCPs) synthesis, reduces neointimal formation in animal models of vascular injury and recently has been shown to inhibit in-stent late loss in a placebo-controlled phase II clinical trial.
Marcella Maddaluno, Gianluca Grassia, Maria Vittoria Di Lauro, Antonio Parisi, Francesco Maione, Carla Cicala, Daniele De Filippis, Teresa Iuvone, Angelo Guglielmotti, Pasquale Maffia, Nicola Mascolo, Armando Ialenti   +11 more
doaj   +9 more sources

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

Nature Medicine, 2019
In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation.
Robert C Wirka, Dhananjay Wagh, David T Paik   +2 more
exaly   +2 more sources

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

Nature Cell Biology, 2015
The use of human pluripotent stem cells for in vitro disease modelling and clinical applications requires protocols that convert these cells into relevant adult cell types. Here, we report the rapid and efficient differentiation of human pluripotent stem
John F O'sullivan, Michael Prummer, Curtis R Warren   +2 more
exaly   +2 more sources

HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype [PDF]

Nature Genetics, 2019
Aortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending ...
Rajeev Malhotra, Xiuqing Guo, Florian Wunderer   +2 more
exaly   +3 more sources

Presence of smooth muscle continuous with the rectal and vaginal walls in the deep perineal space prompts reconsideration of the deep transverse perineal muscle [PDF]

Scientific Reports
The deep transverse perineal muscle was considered a striated muscle within the deep perineal space; however, recent studies suggest that it consists of smooth muscle.
Satoru Muro, Liu Chang, Suthasinee Tharnmanularp, Akimoto Nimura, Hiroshi Churei, Keiichi Akita   +5 more
doaj   +2 more sources

Vascular Smooth Muscle Cells in Atherosclerosis

Circulation Research, 2016
Martin R Bennett, Sanjay Sinha, Gary K Owens   +2 more
exaly   +2 more sources

The extracellular signal-regulated kinase (ERK) pathway: a potential therapeutic target in hypertension [PDF]

Journal of Experimental Pharmacology, 2012
Richard E RobertsSchool of Biomedical Sciences, University of Nottingham, Nottingham, United KingdomAbstract: Hypertension is a risk factor for myocardial infarction, stroke, renal failure, heart failure, and peripheral vascular disease.
Roberts RE
doaj   +4 more sources

Vascular smooth muscle cells in atherosclerosis:Time for a reassessment.

Cardiovascular Research, 2021
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding lesions, but also forming a protective fibrous cap rich in extracellular ...
M. Grootaert, M. Bennett
semanticscholar   +1 more source

Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis.

Circulation, 2021
Vascular smooth muscle cells (VSMCs) have long been associated with phenotypic modulation/plasticity or dedifferentiation. Innovative technologies in cell lineage tracing, single-cell RNA sequencing, and human genomics have been integrated to gain ...
J. Miano, E. Fisher, M. Majesky
semanticscholar   +1 more source