Results 11 to 20 of about 2,710,339 (310)
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 The prime function of the arterial smooth muscle cell (SMC) in adult individuals is to contract and relax, thereby regulating blood flow to target tissues. However, in several vascular diseases, arterial SMCs in the adult vessel undergo major changes in structure and function.
Valerie Z. Wall, Karin E. Bornfeldt
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Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction
Frontiers in Physiology, 2020 Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined.
Jie Sun +13 more
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Fibronectin matrix polymerization regulates smooth muscle cell phenotype through a Rac1 dependent mechanism. [PDF]
PLoS ONE, 2014 Smooth muscle cells are maintained in a differentiated state in the vessel wall, but can be modulated to a synthetic phenotype following injury. Smooth muscle phenotypic modulation is thought to play an important role in the pathology of vascular ...
Feng Shi +4 more
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Vascular Smooth Muscle Cells in Atherosclerosis.
Circulation Research, 2016 The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced plaques are entirely beneficial, for example preventing rupture of the fibrous ...
M. Bennett, S. Sinha, G. Owens
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Notch2 and Notch3 function together to regulate vascular smooth muscle development. [PDF]
PLoS ONE, 2012 Notch signaling has been implicated in the regulation of smooth muscle differentiation, but the precise role of Notch receptors is ill defined. Although Notch3 receptor expression is high in smooth muscle, Notch3 mutant mice are viable and display only ...
Qingqing Wang +3 more
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Neurogenic Inflammation of Guinea-Pig Bladder
Mediators of Inflammation, 1994 Capsaicin, substance P, and ovalbumin, instilled into the bladders of naive and ovalbumin (OVA) sensitized guineapigs caused inflammation, as indicated by increased vascular permeability.
D. E. Bjorling, M. R. Saban, R. Saban
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Cardiovascular Research, 2018 Vascular calcification is associated with a significant increase in all-cause mortality and atherosclerotic plaque rupture. Calcification has been determined to be an active process driven in part by vascular smooth muscle cell (VSMC ...
A. Durham +4 more
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Opiate Modulation of Gastrointestinal Motility and the Actions of Trimebutine
Canadian Journal of Gastroenterology, 1991 Trimebutine is an opiate ligand that interacts with the μ, σ and κ receptor subclasses with approximately equal affinity. Since opiate receptors are widely distributed in the gut, and because opiate receptor subtypes may be involved in excitatory or ...
Stephen M Collins, Edwin E Daniel
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Vascular smooth muscle contraction in hypertension
Cardiovascular Research, 2018 Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia, and chronic kidney disease.
R. Touyz +6 more
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Calcium Handling in Airway Smooth Muscle: Mechanisms and Therapeutic Implications
Canadian Respiratory Journal, 1998 Calcium plays a central role in the activation of many cellular processes, including the most relevant end-point in airway smooth muscle physiology: contraction.
Luke J Janssen
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