Results 71 to 80 of about 16,644 (257)

Alívio da distonia cervical primária com o uso da estimulação magnética transcraniana de baixa freqüência sobre o córtex pré-motor : relato de caso [PDF]

, 2007
Objective: To evaluate the effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on the symptoms of a patient with primary segmental dystonia (PSD).
Allam, Nasser, Barros Filho, Jairo de, Brandão, Pedro, Brasil Neto, Joaquim Pereira, Tomaz, Carlos Alberto Bezerra, Weiler, Fernanda Dias   +5 more
core   +3 more sources

KCNJ2 is Required for NLRP3 Inflammasome Activation That Drives Allergic Airway Inflammation and Remodeling

Advanced Science, EarlyView.
This study aims to evaluate the impact of the potassium channel KCNJ2 on asthma development. KCNJ2 promotes NLRP3 inflammasome activation through both Ca2+ influx and K+ efflux in airway epithelial cells, which drives allergic airway inflammation and remodeling, suggesting a promising therapeutic target for asthma.
Yachao Cui, Shumei Wu, Yang Peng, Yiqi Liu, Li Che, Shiying Chen, Feng Zhang, Dajiang Qin, Shiyue Li, Pixin Ran, Wenguang Yin   +10 more
wiley   +1 more source

Statin usage, vascular diagnosis and vascular risk factors in Parkinson's disease [PDF]

, 2017
Background and aims: Vascular disease is a common comorbidity in Parkinson’s disease patients. Statins are potentially neuroprotective for Parkinson’s disease through non-vascular mechanisms.
Cheng, Kelvin K.W., Grosset, Donald G., Grosset, Katherine A., Swallow, Diane M.A.   +3 more
core   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source

Lihasekrambid [PDF]

, 2007
Lihasekrambid (muscle cramps) on sageli esinev häire jalgades. Patsiendid, kellel esinevad lihasekrambid, pöörduvad sageli neuroloogi, sise- või perearsti poole.
Kaasik, Ain-Elmar, Puksa, Leena
core   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Two Task-Specific Dystonias in One Hand

Tremor and Other Hyperkinetic Movements, 2013
Background: Dystonia is characterized by involuntary muscle contractions that lead to abnormal postures and/or repetitive movements. Task‐specific dystonia only manifests during a specific activity. Case report: We report a case of a female with writer's
Manon Linssen, Cathérine Delnooz, Bart van de Warrenburg   +2 more
doaj   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Myofascial trigger points: spontaneous electrical activity and its consequences for pain induction and propagation

Chinese Medicine, 2011
Active myofascial trigger points are one of the major peripheral pain generators for regional and generalized musculoskeletal pain conditions. Myofascial trigger points are also the targets for acupuncture and/or dry needling therapies.
Fernández-de-las-Peñas César, Ge Hong-You, Yue Shou-Wei   +2 more
doaj   +1 more source

Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin? [PDF]

, 2017
Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch as the basis. Dystonia was originally classified as a basal ganglia disease. It
Bhatia, K, Graybiel, AM, Kaji, R
core   +1 more source