Results 161 to 170 of about 19,233,520 (354)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy

Journal of Cachexia, Sarcopenia and Muscle
Skeletal muscle is the most abundant tissue in the human body and is responsible for movement, metabolism, energy production and longevity. Muscle atrophy is a frequent complication of several diseases and occurs when protein degradation exceeds protein ...
Yidi Zhang, Teng Wang, Ziang Wang, Xin'e Shi, Jianjun Jin   +4 more
doaj   +1 more source

EZH1 as a key mediator of exercise-induced H3K27me3 and H3K4me3 in mouse skeletal muscle

Advanced Exercise and Health Science
Epigenetic modification is a key mechanism that enhances the response of skeletal muscle to exercise training. Exercise-induced H3K27me3, which is co-modified with H3K4me3, is crucial for gene responses and adaptation in skeletal muscle; however, how ...
Junya Shimizu, Naoki Horii, Yusuke Ono, Fuminori Kawano   +3 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and Recovery after Muscle Injury

International Journal of Molecular Sciences
Ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme originally found in the brain. Our previous work revealed that UCHL1 was also expressed in skeletal muscle and affected myoblast differentiation and metabolism. In this study, we further tested the role of UCHL1 in myogenesis and muscle regeneration following muscle ischemia ...
Antony, Ryan, Aby, Katherine, Montgomery, Morgan, Li, Yifan   +3 more
openaire   +2 more sources

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source

Supplementary Feeding Regulates Muscle Development of Oula Sheep (Tibetan Sheep, Ovis aries) Through Glucose Metabolism Pathway

Animals
To investigate the genetic regulatory mechanism of supplementary feeding on muscle development in Oula sheep, we employed transcriptomic analysis to explore the differentially expressed genes (DEGs) in the longissimus dorsi muscle of Oula sheep at ...
Yumeng Li, Yanhao Wang, Mingyi Yan, Sen Wu, Meng Liu, Sayed Haidar Abbas Raza   +5 more
doaj   +1 more source

Hospital Readmission After Traumatic Brain Injury Hospitalization in Community‐Dwelling Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the risk of hospital readmission after an index hospitalization for TBI in older adults. Methods Using data from the Atherosclerosis Risk in Communities (ARIC) study, we used propensity score matching of individuals with an index TBI‐related hospitalization to individuals with (1) non‐TBI hospitalizations (primary analysis)
Rachel Thomas, Connor A. Law, Joan A. Casey, Thomas Mosley, Rebecca F. Gottesman, Ramon Diaz‐Arrastia, Holly Elser, Andrea L. C. Schneider   +7 more
wiley   +1 more source

Does Muscle Development of Sport Horses Using Water Treadmill Exercise as Part of a Long-Term Training Programme Differ from That of Horses Not Using Water Treadmill Exercise?

Animals
Water treadmill (WT) exercise has become a popular tool for equine training and rehabilitation. However, few studies describe the long-term effects of WT exercise in low water on muscle development (MD). This study’s objectives were to compare MD changes
Carolyne Tranquille, Kathryn Nankervis, Jack Tacey, Emily Hopkins, Isabeau Deckers, Vicki Walker, Russell MacKechnie-Guire, Richard Newton, Rachel Murray   +8 more
doaj   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source