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Denervation produces different single fiber phenotypes in fast- and slow-twitch hindlimb muscles of the rat

American Journal of Physiology-Cell Physiology, 2006
Using a single, mechanically skinned fiber approach, we tested the hypothesis that denervation (0 to 50 days) of skeletal muscles that do not overlap in fiber type composition [extensor digitorum longus (EDL) and soleus (SOL) muscles of Long-Evans hooded rats] leads to development of different fiber phenotypes.
Patterson, Michael.   +2 more
openaire   +2 more sources

Diaphragm Assessment in Mice Overexpressing Phospholamban in Slow‐Twitch Type I Muscle Fibers

The FASEB Journal, 2016
Phospholamban (PLN) is a small transmembrane protein that regulates the sarco(endo)plasmic reticulum Ca 2+ ‐ATPase (SERCA) pump through direct physical interactions. Recent work published by our laboratory revealed that when PLN was transgenetically overexpressed in mice (
Paige J. Chambers   +2 more
openaire   +1 more source

Differential effects of peroxynitrite on contractile protein properties in fast- and slow-twitch skeletal muscle fibers of rat

Journal of Applied Physiology, 2011
Oxidative modification of contractile proteins is thought to be a key factor in muscle weakness observed in many pathophysiological conditions. In particular, peroxynitrite (ONOO−), a potent short-lived oxidant, is a likely candidate responsible for this contractile dysfunction. In this study ONOO− or 3-morpholinosydnonimine (Sin-1, a ONOO− donor) was
T L, Dutka, J P, Mollica, G D, Lamb
openaire   +2 more sources

Na+ currents near and away from endplates on human fast and slow twitch muscle fibers

Muscle & Nerve, 1993
AbstractFast and slow twitch muscle fibers have distinct contractile properties. Here we determined that membrane excitability also varies with fiber type. Na+ currents (INA) were studied with the loose‐patch voltage clamp technique on 29 histochemically classified human intercostal skeletal muscle fibers at the endplate border and <200 μm from the ...
R L, Ruff, D, Whittlesey
openaire   +2 more sources

Phytol Promotes the Formation of Slow-Twitch Muscle Fibers through PGC-1α/miRNA but Not Mitochondria Oxidation

Journal of Agricultural and Food Chemistry, 2017
Phytol is a side chain of chlorophyll belonging to the side-chain double terpenoid. When animals consume food rich in chlorophyll, phytol can be broken down to phytanic acid after digestion. It was reported that feeding animals with different varieties and levels of forage could significant improve pH and marbling score of steer and lamb carcasses, but
Kelin Yang   +14 more
openaire   +2 more sources

Contractile properties, structure and fiber phenotype of intact and regenerating slow-twitch muscles of mice treated with cyclosporin A

Cell and Tissue Research, 2002
We have studied the contractile properties, structure, fiber-type composition, and myosin heavy chain (MyHC) expression pattern of regenerating and intact soleus muscles of adult CBA/J mice treated with cyclosporin A (CsA) or vehicle solutions (Cremophor, saline).
Andrey, Irintchev   +4 more
openaire   +2 more sources

Early effects of denervation on sarcoplasmic reticulum properties of slow-twitch rat muscle fibres

Pfl�gers Archiv European Journal of Physiology, 1997
The Ca2+ release activity of the sarcoplasmic reticulum (SR) in chemically skinned single slow-twitch fibres from control, 2-day and 7-day denervated rat soleus muscle was studied. Histochemical fibre type composition of the whole muscle, electrophysiological properties and the Ca2+ sensitivity of tension development by single muscle fibres were also ...
MIDRIO, MENOTTI   +4 more
openaire   +4 more sources

COEXISTENCE OF 2 CALSEQUESTRIN ISOFORMS IN RABBIT SLOW-TWITCH SKELETAL-MUSCLE FIBERS

1992
The cardiac and skeletal muscle isoforms of calsequestrin (CS), the low affinity, high capacity Ca2+ binding protein localized in the lumen of sarcoplasmic reticulum, are the products of two different genes (Fliegel, L., Leberer, E., Green, N.M. and MacLennan, D.H. (1982) FEBS Lett.
BIRAL D   +3 more
openaire   +1 more source

Heterogeneous expression of myosin light chain 1 in a human slow-twitch muscle fiber.

Journal of biochemistry, 1981
Heterogeneous expression of myosin light chain 1 was observed in a human slow-twitch muscle fiber on two dimensional gel electrophoresis. Three spots were found around the L1 region and one of them corresponded to fast type L1. The nature of the heterogeneity is discussed.
S, Ishiura   +3 more
openaire   +1 more source

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