Results 191 to 200 of about 1,126,451 (240)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli   +5 more
wiley   +1 more source

<i>WNT7A</i> mRNA Lipid Nanoparticles Promote Muscle Hypertrophy and Reduce Fatty Infiltration. [PDF]

open access: yesCell Mol Bioeng
Santiago LM   +8 more
europepmc   +1 more source

The Impact of Water Exchange on Estimates of Myocardial Blood Flow and Extracellular Volume Fraction Using Dynamic Contrast‐Enhanced MRI in Patients Treated for Severe Aortic Stenosis

open access: yesMagnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To investigate the impact of intra/extracellular water exchange (WX) on quantitative dynamic contrast‐enhanced (DCE) MRI in patients with severe aortic stenosis (AS). The aims were to compare low‐dose (WX insensitive) and high‐dose (WX sensitive) DCE‐MRI measurements, and to compare data acquired before and after aortic valve ...
Alex Makins   +5 more
wiley   +1 more source

Non‐Invasive Triage of Bladder Outlet Obstruction and Detrusor Underactivity in Men With Lower Urinary Tract Symptoms: A Narrative Review and Conceptual Framework for Depth‐Aware Multimodal Transcutaneous Testing

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Differentiating bladder outlet obstruction (BOO) from detrusor underactivity (DU) remains a major unmet need in the management of lower urinary tract symptoms in men. Although pressure–flow urodynamics provide a definitive physiological classification, their invasiveness limits their widespread use.
Sehwan Kim   +3 more
wiley   +1 more source

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Purpose To investigate the adenosine receptor (AR) mechanism underlying bladder outlet obstruction (BOO)‐related bladder dysfunction, we examined the expression level of AR subtypes in bladder tissues, and the effects of AR subtypes A2B & A3 modulation on bladder activity using male BOO rats, and Dahl rats with A2B receptor deletion. Materials
Masahiro Kurobe   +8 more
wiley   +1 more source

Fear‐Avoidance and Overactive Bladder: Toward a Mechanism‐Informed Model of Care

open access: yesNeurourology and Urodynamics, EarlyView.
ABSTRACT Aims Overactive bladder (OAB) is associated with substantial psychological burden, yet existing biopsychosocial frameworks acknowledge that psychological factors shape outcomes without explaining the cognitive and behavioral mechanisms through which that influence operates.
Rupal M. Patel, Andrea Wood
wiley   +1 more source

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