Results 51 to 60 of about 126,847 (293)

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

JBMR Plus, Volume 7, Issue 1, January 2023., 2023
ABSTRACT Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐threatening to milder manifestations only in adulthood.
Flavia Amadeu de Oliveira, Fatma F. Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan   +7 more
wiley   +1 more source

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Application of Fractional Derivatives in Characterization of ECG graphs of Right Ventricular Hypertrophy Patients [PDF]

arXiv, 2017
There are many functions which are continuous everywhere but non-differentiable at some or all points such functions are termed as unreachable functions. Graphs representing such unreachable functions are called unreachable graphs. For example, ECG is such an unreachable graph.
arxiv  

Tall Stature and Scoliosis Associated With a Novel Homozygous Loss‐of‐Function Missense Variant in NPR3

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT NPR3‐related tall stature is characterized by tall stature, elongated big toes, and additional epiphyses in hand and foot bones. The condition is caused by biallelic loss‐of‐function variants affecting natriuretic peptide receptor 3 (NPR3). Five individuals from four different families have been reported.
Pierre Moffatt, Chantal Janelle, Valancy Miranda, Ghalib Bardai, Frank Rauch   +4 more
wiley   +1 more source

Obliterative portal venopathy: A neglected and probably misdiagnosed disease with peculiar etiology in South America

JGH Open, Volume 6, Issue 12, Page 904-909, December 2022., 2022
Classically described in the group of non‐cirrhotic portal hypertension, obliterative portal venopathy (OPV) causes are still unknown. Our aim is to describe the characteristics of 43 OPV patients and potential risk factors. Clinically significant portal hypertension was found in 28% of cases. The most frequent indication for liver biopsy was elevation
Vinícius Nunes, Luiz A R de Freitas, Juliana R de Freitas, Caio Araújo, Gildásio N Junior, Maria I Schinoni, Fernando Bessone, Raymundo Paraná   +7 more
wiley   +1 more source

Shape differences in the semitendinosus following tendon harvesting for anterior cruciate ligament reconstruction

Journal of Orthopaedic Research, Volume 41, Issue 1, Page 44-53, January 2023., 2023
Abstract Following hamstring autograft anterior cruciate ligament reconstruction (ACLR), muscle length, cross‐sectional area, and volume are reduced. However, these discrete measures of morphology do not account for complex three‐dimensional muscle shape. The primary aim of this study was to determine between‐limb semitendinosus (ST) shape and regional
William du Moulin, Matthew Bourne, Laura E. Diamond, Jason Konrath, Christopher Vertullo, David Lloyd, David J. Saxby   +6 more
wiley   +1 more source

CEUS‐assessed supraspinatus muscle perfusion improves after tendon repair and predicts anatomical and functional outcome: A 1‐year prospective pilot study

Journal of Orthopaedic Research, Volume 41, Issue 2, Page 426-435, February 2023., 2023
Abstract Rotator cuff tear including SSP (Supraspinatus) tendon tears are a very common and often painful condition with several therapeutic options such as tendon repair. Reflected by the high retear rates, the preoperative selection of patients suitable for surgery or conservative treatment, which often yields comparable results, remains difficult ...
Paul Mick, Pierre Kunz, Christian Fischer, Sascha Gross, Julian Doll   +4 more
wiley   +1 more source

Disseminated cysticercosis with huge muscle hypertrophy

Indian Journal of Dermatology, 2009
Cysticercosis is caused by cysticercus cellulose, which is the larva of Taenia solium, the pork tapeworm. The larvae are carried in the blood stream after penetrating the walls of the alimentary tract and they lodge in different tissues like the skin, skeletal muscles, brain, fundus and heart, to cause disseminated cysticercosis.
Debabrata Bandyopadhyay, Sumit Sen
openaire   +4 more sources

Who was the real sabertooth predator: Thylacosmilus or Thylacoleo?

The Anatomical Record, EarlyView.
Abstract Sabertoothed mammalian predators, all now extinct, were almost exclusively feloid carnivorans (Eutheria, Placentalia): here a couple of extinct metatherian predators are considered in comparison with the placental sabertooths. Thylacosmilus (the “marsupial sabertooth”) and Thylacoleo (the “marsupial lion”) were both relatively large (puma ...
Christine M. Janis
wiley   +1 more source

Bending performance changes during prolonged canine eruption in saber‐toothed carnivores: A case study of Smilodon fatalis

The Anatomical Record, EarlyView.
Abstract The canine of saber‐toothed predators represents one of the most specialized dental structures known. Hypotheses about the function of hypertrophied canines range from display and conspecific interaction, soft food processing, to active prey acquisition.
Z. Jack Tseng
wiley   +1 more source