Results 81 to 90 of about 1,793,126 (357)

Titin‐based mechanosensing modulates muscle hypertrophy [PDF]

Journal of Cachexia, Sarcopenia and Muscle, 2018
AbstractBackgroundTitin is an elastic sarcomeric filament that has been proposed to play a key role in mechanosensing and trophicity of muscle. However, evidence for this proposal is scarce due to the lack of appropriate experimental models to directly test the role of titin in mechanosensing.MethodsWe used unilateral diaphragm denervation (UDD) in ...
van der Pijl, Robbert, Strom, Joshua, Conijn, Stefan, Lindqvist, Johan, Labeit, Siegfried, Granzier, Henk, Ottenheijm, Coen   +6 more
openaire   +4 more sources

Dysfunctional TRIM31 of POMC Neurons Provokes Hypothalamic Injury and Peripheral Metabolic Disorder under Long‐Term Fine Particulate Matter Exposure

Advanced Science, EarlyView.
Particulate matter ≤2.5 µm (PM2.5) elevates risks of neurological and chronic metabolic diseases, but the underlying mechanisms linking PM2.5‐induced central nervous system (CNS) injury to metabolic dysfunction remain unclear. Hypothalamic pro‐opiomelanocortin‐expressing (POMC+) neurons regulate systemic metabolic homeostasis, and tripartite motif ...
Chenxu Ge, Jiamao Lin, Changsheng Yang, Chuanwang Miao, Fengxiang Li, Shuqiang Zhao, Lei Zou, Xuedong Teng, Lina Liu, Tingguang Li, Yan Sun, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Minxuan Xu, Minghui Chang, Jun Tan, Yanrong Ren, Bochu Wang   +21 more
wiley   +1 more source

Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. [PDF]

PLoS ONE, 2013
Hypertrophic stimuli, such as mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles.
Tomoyuki Koya, Sono Nishizawa, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Tatsuro Egawa, Akira Nakai, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Moroe Beppu, Katsumasa Goto   +13 more
doaj   +1 more source

Periodized Resistance Training for Enhancing Skeletal Muscle Hypertrophy and Strength: A Mini-Review

Frontiers in Physiology, 2019
Prescribing the proper resistance training (RT) program is critical to optimize skeletal muscle hypertrophy and strength. Periodization is a strategy that entails planned manipulations of training variables to maximize fitness adaptations while ...
Jonathan W. Evans
semanticscholar   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Comparative transcriptomic analysis revealed potential mechanisms regulating the hypertrophy of goose pectoral muscles

Poultry Science
Pectoral muscle development is an important economic trait. According to the different essence, muscle development can be divided into 2 processes: embryonic muscle fiber generation and postnatal muscle fiber hypertrophy, and postnatal muscle fiber ...
Xinyue Hu, Yali Liu, Bincheng Tang, Jiwei Hu, Hua He, Hehe Liu, Liang Li, Shenqiang Hu, Jiwen Wang   +8 more
doaj   +1 more source

Autophagy signaling in hypertrophied muscles of diabetic and control rats

FEBS Open Bio, 2023
Autophagy plays a vital role in cell homeostasis by eliminating nonfunctional components and promoting cell survival. Here, we examined the levels of autophagy signaling proteins after 7 days of overload hypertrophy in the extensor digitorum longus (EDL)
Maria V. M. Scervino, Marco A. S. Fortes, Kaio F. Vitzel, Diego R. deSouza, Gilson M. Murata, Giovanna O. Santana, Eliane B. daSilva, Adriana C. Levada‐Pires, Wilson M. T. Kuwabara, Tatiana C. A. Loureiro, Rui Curi   +10 more
doaj   +1 more source

Use of AgomiR and AntagomiR technologies to alter satellite cell proliferation in vitro, miRNA expression, and muscle fiber hypertrophy in intrauterine growth-restricted lambs [PDF]

, 2023
M. A. Greene, George A. Worley, Aliute Udoka, Rhonda R. Powell, Terri Bruce, J. L. Klotz, William C. Bridges, S. K. Duckett   +7 more
openalex   +1 more source

Heat stress inhibits skeletal muscle hypertrophy [PDF]

Cell Stress & Chaperones, 2005
Heat shock proteins (Hsps) are molecular chaperones that aid in protein synthesis and trafficking and have been shown to protect cells/tissues from various protein damaging stressors. To determine the extent to which a single heat stress and the concurrent accumulation of Hsps influences the early events of skeletal muscle hypertrophy, Sprague-Dawley ...
Bruce C, Frier, Marius, Locke
openaire   +2 more sources

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source