Results 81 to 90 of about 255,284 (355)

Do the anatomical and physiological properties of a muscle determine its adaptive response to different loading protocols?

Physiological Reports, 2020
It has been proposed that superior muscle hypertrophy may be obtained by training muscles predominant in type I fibers with lighter loads and those predominant in type II fibers with heavier loads.
Brad J. Schoenfeld, Andrew D. Vigotsky, Jozo Grgic, Cody Haun, Bret Contreras, Kenneth Delcastillo, Aston Francis, Gilda Cote, Andrew Alto   +8 more
doaj   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. [PDF]

PLoS ONE, 2013
Hypertrophic stimuli, such as mechanical stress and overloading, induce stress response, which is mediated by heat shock transcription factor 1 (HSF1), and up-regulate heat shock proteins (HSPs) in mammalian skeletal muscles.
Tomoyuki Koya, Sono Nishizawa, Yoshitaka Ohno, Ayumi Goto, Akihiro Ikuta, Miho Suzuki, Tomotaka Ohira, Tatsuro Egawa, Akira Nakai, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Moroe Beppu, Katsumasa Goto   +13 more
doaj   +1 more source

Periodization for Massive Strength Gains [PDF]

, 2019
In order to create the perfect resistance training program for their athletes, coaches must master the ability to control all variables of training over time in order to maximize physiological responses - this is a concept known as periodization (3, 6, 7,
Yanes, Benjamin L.
core   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Comparative transcriptomic analysis revealed potential mechanisms regulating the hypertrophy of goose pectoral muscles

Poultry Science
Pectoral muscle development is an important economic trait. According to the different essence, muscle development can be divided into 2 processes: embryonic muscle fiber generation and postnatal muscle fiber hypertrophy, and postnatal muscle fiber ...
Xinyue Hu, Yali Liu, Bincheng Tang, Jiwei Hu, Hua He, Hehe Liu, Liang Li, Shenqiang Hu, Jiwen Wang   +8 more
doaj   +1 more source

Effects of Chronic Akt/mTOR Inhibition by Rapamycin on Mechanical Overload–Induced Hypertrophy and Myosin Heavy Chain Transition in Masseter Muscle

Journal of Pharmacological Sciences, 2013
To examine the effects of the Akt/mammalian target of rapamycin (mTOR) pathway on masseter muscle hypertrophy and myosin heavy chain (MHC) transition in response to mechanical overload, we analyzed the effects of bite-opening (BO) on the hypertrophy and ...
Daisuke Umeki, Yoshiki Ohnuki, Yasumasa Mototani, Kouichi Shiozawa, Takayuki Fujita, Yoshiki Nakamura, Yasutake Saeki, Satoshi Okumura   +7 more
doaj   +1 more source

Autophagy signaling in hypertrophied muscles of diabetic and control rats

FEBS Open Bio, 2023
Autophagy plays a vital role in cell homeostasis by eliminating nonfunctional components and promoting cell survival. Here, we examined the levels of autophagy signaling proteins after 7 days of overload hypertrophy in the extensor digitorum longus (EDL)
Maria V. M. Scervino, Marco A. S. Fortes, Kaio F. Vitzel, Diego R. deSouza, Gilson M. Murata, Giovanna O. Santana, Eliane B. daSilva, Adriana C. Levada‐Pires, Wilson M. T. Kuwabara, Tatiana C. A. Loureiro, Rui Curi   +10 more
doaj   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source