Results 81 to 90 of about 126,384 (221)

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
The gut microbiome is a potential target for treating cardiovascular disease. It is found that prophylactic administration of Flavonifractor plautii or its metabolite desaminotyrosine (DAT) exerts pleiotropic cardioprotective effects via promoting cardiomyocyte survival and attenuating cardiac inflammation against myocardial ischemia/reperfusion (I/R ...
Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song   +21 more
wiley   +1 more source

Insect‐specific viruses used in biocontrol of mosquito‐borne diseases

Interdisciplinary Medicine, Volume 1, Issue 1, January 2023., 2023
Insect‐specific RNA viruses (ISRVs) are involved in a wide range of families including Flaviviridae, Bunyaviridae, Negeviruses, Togaviridae, Reoviridae, Mesoniviridae, and Rhabdoviridae, which cannot infect vertebrates, including humans. However, ISRVs can infect and replicate in mosquitoes, interfering with the replication of mosquito‐borne viruses ...
Jiating Chen, Shengqun Deng, Hongjuan Peng   +2 more
wiley   +1 more source

Effects of day-time feeding on murine skeletal muscle growth and synthesis

Journal of Nutrition & Intermediary Metabolism, 2019
Muscle mass is controlled by the balance between muscle synthesis and degradation. Although nutrition is important for the maintenance of muscle mass and growth, the effects of feeding time have remained unclear.
Shinya Aoyama, Shuichi Kojima, Keisuke Sasaki, Takeru Shimoda, Kengo Takahashi, Rina Hirooka, Yu Tahara, Shigenobu Shibata   +7 more
doaj  

MOLECULAR GENETIC FACTORS OF THE SKELETAL MUSCLE HYPERTROPHY

Вісник проблем біології і медицини, 2018
Skeletal muscle mass is an important indicator of human health and physical performance. Representing about 50% of body weight, skeletal muscles play a key role not only in motor activity, but also in maintaining the body’s metabolic status.
Drozdovska S. B., Kalinski M. I.
doaj   +1 more source

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source

Environmental exposure of the general population to cadmium as a risk factor of the damage to the nervous system: A critical review of current data

Journal of Applied Toxicology, Volume 43, Issue 1, Page 66-88, January 2023., 2023
Abstract Nowadays, more and more attention has been focused on the risk of the neurotoxic action of cadmium (Cd) under environmental exposure. Due to the growing incidence of nervous system diseases, including neurodegenerative changes, and suggested involvement of Cd in their aetiopathogenesis, this review aimed to discuss critically this element ...
Agnieszka Ruczaj, Małgorzata M. Brzóska   +1 more
wiley   +1 more source

Application of Fractional Derivatives in Characterization of ECG graphs of Right Ventricular Hypertrophy Patients [PDF]

arXiv, 2017
There are many functions which are continuous everywhere but non-differentiable at some or all points such functions are termed as unreachable functions. Graphs representing such unreachable functions are called unreachable graphs. For example, ECG is such an unreachable graph.
arxiv  

IL‐33‐Induced TREM2+ Macrophages Promote Pathological New Bone Formation Through CREG1‐IGF2R Axis in Ankylosing Spondylitis

Advanced Science, EarlyView.
This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao, Siwen Chen, Hua Chao, Zihao Li, Hao Yang, Dongying Chen, Sifang Li, Shuai Zhang, Jingyu Zhang, Jianru Wang, Zemin Li, Xiang Li, Zhongping Zhan, Tangming Guan, Yiwen Zhang, Wende Li, Hui Liu   +16 more
wiley   +1 more source

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

JBMR Plus, Volume 7, Issue 1, January 2023., 2023
ABSTRACT Hypophosphatasia (HPP), caused by loss‐of‐function mutations in the ALPL gene encoding tissue‐nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life‐threatening to milder manifestations only in adulthood.
Flavia Amadeu de Oliveira, Fatma F. Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan   +7 more
wiley   +1 more source