Results 41 to 50 of about 433,698 (315)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Inspiratory muscle training abolishes the blood lactate increase associated with volitional hyperpnoea superimposed on exercise and accelerates lactate and oxygen uptake kinetics at the onset of exercise

, 2011
We examined the effects of inspiratory muscle training (IMT) upon volitional hyperpnoea-mediated increases in blood lactate ([lac−]B) during cycling at maximal lactate steady state (MLSS) power, and blood lactate and oxygen uptake kinetics at the onset ...
Brown, PI, Johnson, Michael A., Graham R. Sharpe, Johnson, MA, Brown, Peter I., Michael A. Johnson, Peter I. Brown, Sharpe, GR, Sharpe, Graham R.   +8 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Increase of jump performance during GH treatment in short children born SGA

Frontiers in Endocrinology, 2023
BackgroundShort children born small for gestational age (SGA) often have low muscle mass. Studies on maximal isometric grip-force (MIGF) observed lower muscle strength in these children.
Roland Schweizer, David D. Martin, Gerhard Binder   +2 more
doaj   +1 more source

Comments on point:counterpoint: skeletal muscle mechanical efficiency does/does not increase with age. [PDF]

, 2013
Comments to the ...
G. Layec, D. Malatesta, Dalton, Brian H, C. R. Hart, Ferguson, Richard A, Rice, Charles L, C. L. Rice, Hart, Corey R, F. Borrani, C. J. McNeil, Power, Geoff A, McNeil, Chris J, A.E. Minetti, Borrani, Fabio, N. A. Maffiuletti, L. Passfield, Hunter, Gary R, Manini, Todd M, Maffiuletti, Nicola A, Trinity, Joel D, Sasaki, Kazushige, Minetti, Alberto E, G. A. Power, B. H. Dalton, Coen, Paul M, Hopker, James G., R. A. Ferguson, K. Sasaki, T. M. Manini, Fisher, Gordon, P. M. Coen, Layec, Gwenael, J. D. Trinity, Passfield, Louis, G. Fisher, Conley, Kevin E, J. Hopker, Malatesta, Davide, K. E. Conley, G. R. Hunter   +39 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Reliability of measurement of muscle tone and muscle power in stroke patients [PDF]

Age and Ageing, 2000
to establish the reliability of the modified Ashworth scale for measuring muscle tone in a range of muscle groups (elbow, wrist, knee and ankle; flexors and extensors) and of the Medical Research Council scale for measuring muscle power in the same muscle groups and their direct antagonists.a cross-sectional study involving repeated measures by two ...
J M, Gregson, M J, Leathley, A P, Moore, T L, Smith, A K, Sharma, C L, Watkins   +5 more
openaire   +2 more sources

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Prior upper body exercise reduces cycling work capacity but not critical power

, 2014
Purpose: This study examined whether metabolite accumulation, induced by prior upper body exercise, affected the power–duration relationship for leg cycle ...
Mills, Dean E., Brown, PI, Johnson, Michael A., Johnson, MA, Brown, Peter I., Mills, DE, Sharpe, GR, Sharpe, Graham R.   +7 more
core   +1 more source