Results 251 to 260 of about 176,030 (314)

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

Iron Deficiency Impairs Muscle Stem Cell Proliferation and Skeletal Muscle Regeneration via HIF-2α Stabilization. [PDF]

J Cachexia Sarcopenia Muscle
Fu W, Liu Y, Yin A, Xie L, Yin H.
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Cold-Induced Suppression of Myogenesis in Skeletal Muscle Stem Cells Contributes to Delayed Muscle Regeneration During Hibernation. [PDF]

FASEB J
Miyaji T, Kasuya R, Monden M, Tamura Y, Shimozuru M, Tsubota T, Tsukamoto D, Li G, Kawano S, Watanabe Y, Yamaguchi Y, Watanabe M, Miyazaki M.   +12 more
europepmc   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Branched actin polymerization drives invasive protrusion formation to promote myoblast fusion during mouse skeletal muscle regeneration. [PDF]

Elife
Lu Y, Walji T, Pandey P, Zhou C, Habela CW, Snapper SB, Li R, Chen EH.   +7 more
europepmc   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Muscle Stem Cell Microenvironment and Functions in Muscle Regeneration. [PDF]

Biomolecules
Li W, Chen M, Zhang L.
europepmc   +1 more source

Buzhong Yiqi Decoction accelerates skeletal muscle regeneration. [PDF]

Acta Biochim Biophys Sin (Shanghai)
Gao T, Hu X, Chen Y, Yang Q, Niu X, Li H, Zhu D, Zeng P, Zhang Y, Zhang D.   +9 more
europepmc   +1 more source

Gli1 regulates fibro/adipogenic progenitor function through modulation of Ido1 in muscle regeneration. [PDF]

Int J Biol Sci
Han L, Zhang F, Zhang J, Li X, Wang K, Liu B, Song J, Liu X, Qian Y, Li K, Lei Y, Spits C, Chang Y, Zhuang C, Yu Z, Zhao Y, Peng J.   +16 more
europepmc   +1 more source